Molecular logic gate operations using one-dimensional DNA nanotechnology

2018 ◽  
Vol 6 (3) ◽  
pp. 452-455 ◽  
Author(s):  
Muhit Rana ◽  
Erik E. Augspurger ◽  
Mustafa Salih Hizir ◽  
Esma Alp ◽  
Mehmet V. Yigit
Keyword(s):  
Metal Ion ◽  
Logic Gate ◽  
Dna Nanotechnology ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
One Dimensional ◽  
Molecular Logic Gate ◽  
Molecular Logic

Hybridization chain reaction is programmed for DNA-based molecular logic gate operations using specific initiators and metal ion combinations.

Evaluation of metal ion sensing behaviour of fluorescent probe along with its precursors: PET-CHEF mechanism, molecular logic gate behaviour and DFT studies

2019 ◽  
Vol 95 (1-2) ◽  
pp. 79-89 ◽  
Author(s):  
Chitra Varadaraju ◽  
Mosae Selvakumar Paulraj ◽  
G. Tamilselvan ◽  
I. V. Muthu Vijayan Enoch ◽  
V. Srinivasadesikan ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Metal Ion ◽  
Logic Gate ◽  
Dft Studies ◽  
Molecular Logic Gate ◽  
Ion Sensing ◽  
Molecular Logic ◽  
Metal Ion Sensing

A Molecular Logic Gate Enables Super-Resolved Imaging of Intracellular Lipid Droplets

2019 ◽  
Author(s):  
Adam Eördögh ◽  
Carolina Paganini ◽  
Dorothea Pinotsi ◽  
Paolo Arosio ◽  
Pablo Rivera-Fuentes
Keyword(s):  
Single Molecule ◽  
Lipid Droplets ◽  
Neutral Lipids ◽  
Logic Gate ◽  
Living Cells ◽  
Three Dimensions ◽  
Single Molecule Imaging ◽  
Molecular Logic Gate ◽  
Molecular Logic ◽  
Cellular Compartments

<div>Photoactivatable dyes enable single-molecule imaging in biology. Despite progress in the development of new fluorophores and labeling strategies, many cellular compartments remain difficult to image beyond the limit of diffraction in living cells. For example, lipid droplets, which are organelles that contain mostly neutral lipids, have eluded single-molecule imaging. To visualize these challenging subcellular targets, it is necessary to develop new fluorescent molecular devices beyond simple on/off switches. Here, we report a fluorogenic molecular logic gate that can be used to image single molecules associated with lipid droplets with excellent specificity. This probe requires the subsequent action of light, a lipophilic environment and a competent nucleophile to produce a fluorescent product. The combination of these requirements results in a probe that can be used to image the boundary of lipid droplets in three dimensions with resolutions beyond the limit of diffraction. Moreover, this probe enables single-molecule tracking of lipids within and between droplets in living cells.</div>

scholarly journals Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Feng Li ◽  
Wenting Yu ◽  
Jiaojiao Zhang ◽  
Yuhang Dong ◽  
Xiaohui Ding ◽  
...  
Keyword(s):  
Steric Effect ◽  
Sirna Delivery ◽  
Dna Nanotechnology ◽  
Hybridization Chain Reaction ◽  
Dna Nanostructures ◽  
Chain Reaction ◽  
Dna Hairpins ◽  
In Vivo Experiments ◽  
Dna And Rna

AbstractDNA nanostructures have been demonstrated as promising carriers for gene delivery. In the carrier design, spatiotemporally programmable assembly of DNA under nanoconfinement is important but has proven highly challenging due to the complexity–scalability–error of DNA. Herein, a DNA nanotechnology-based strategy via the cascade hybridization chain reaction (HCR) of DNA hairpins in polymeric nanoframework has been developed to achieve spatiotemporally programmable assembly of DNA under nanoconfinement for precise siRNA delivery. The nanoframework is prepared via precipitation polymerization with Acrydite-DNA as cross-linker. The potential energy stored in the loops of DNA hairpins can overcome the steric effect in the nanoframework, which can help initiate cascade HCR of DNA hairpins and achieve efficient siRNA loading. The designer tethering sequence between DNA and RNA guarantees a triphosadenine triggered siRNA release specifically in cellular cytoplasm. Nanoframework provides stability and ease of functionalization, which helps address the complexity–scalability–error of DNA. It is exemplified that the phenylboronate installation on nanoframework enhanced cellular uptake and smoothed the lysosomal escape. Cellular results show that the siRNA loaded nanoframework down-regulated the levels of relevant mRNA and protein. In vivo experiments show significant therapeutic efficacy of using siPLK1 loaded nanoframework to suppress tumor growth.

Boolean operations mediated by an ion-pair receptor of a multi-readout molecular logic gate

2013 ◽  
Vol 49 (94) ◽  
pp. 11056 ◽  
Author(s):  
Raúl Gotor ◽  
Ana M. Costero ◽  
Salvador Gil ◽  
Margarita Parra ◽  
Pablo Gaviña ◽  
...  
Keyword(s):  
Logic Gate ◽  
Ion Pair ◽  
Boolean Operations ◽  
Molecular Logic Gate ◽  
Molecular Logic

Recent advances in molecular logic gate chemosensors based on luminescent metal organic frameworks

2021 ◽  
Author(s):  
Bei Li ◽  
Dongsheng Zhao ◽  
Feng Wang ◽  
Xiaoxian Zhang ◽  
Wenqian Li ◽  
...  
Keyword(s):  
Logic Gate ◽  
Metal Organic Frameworks ◽  
Logic Gates ◽  
Design Strategies ◽  
Molecular Logic Gate ◽  
Future Developments ◽  
Molecular Logic ◽  
Molecular Logic Gates ◽  
Recent Advances ◽  
Metal Organic

This review covers the latest advancements of molecular logic gates based on LMOF. The classification, design strategies, related sensing mechanisms, future developments, and challenges of LMOFs-based logic gates are discussed.

A fluorescent colorimetric azo dye based chemosensor for detection of S2− in perfect aqueous solution and its application in real sample analysis and building a molecular logic gate

2018 ◽  
Vol 10 (20) ◽  
pp. 2317-2326 ◽  
Author(s):  
Amit Kumar Manna ◽  
Jahangir Mondal ◽  
Rukmani Chandra ◽  
Kalyani Rout ◽  
Goutam Kumar Patra
Keyword(s):  
Aqueous Solution ◽  
Schiff Base ◽  
Azo Dye ◽  
Color Change ◽  
Logic Gate ◽  
Real Sample ◽  
Sample Analysis ◽  
Real Sample Analysis ◽  
Molecular Logic Gate ◽  
Molecular Logic

A fluorescent-colorimetric azo dye based bis-Schiff base chemosensor, L, has been developed. L can selectively detect S2− through a color change from yellow to orange in perfect aqueous solution by deprotonation mechanism.

Triazole-appended pyrano[2,3-c]pyrazolone based colorimetric chemosensors for recognition of Fe3+ ions and their molecular logic gate behavior

2019 ◽  
Vol 11 (25) ◽  
pp. 3230-3243 ◽  
Author(s):  
Harshita Jain ◽  
Nidhi Deswal ◽  
Ankita Joshi ◽  
C. N. Ramachandran ◽  
Rakesh Kumar
Keyword(s):  
Logic Gate ◽  
Practical Applications ◽  
Molecular Logic Gate ◽  
Molecular Logic

Two novel triazole-appended pyrano[2,3-c]pyrazolone based colorimetric and reversible chemosensors have been synthesized for recognition of Fe3+ ions for practical applications.

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