Sustained drug release and cancer treatment by an injectable and biodegradable cyanoacrylate-based local drug delivery system

2018 ◽  
Vol 6 (8) ◽  
pp. 1216-1225 ◽  
Author(s):  
Tao Zhang ◽  
Yongjia Tang ◽  
Wei Zhang ◽  
Shan Liu ◽  
Yumei Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Treatment ◽  
Anticancer Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Sustained Drug Release ◽  
System P ◽  
Local Drug Delivery System

A novel injectable and biodegradable cross-linked cyanoacrylate-based local drug delivery system with excellent anticancer activity.

scholarly journals Kinetics of drug release from a biodegradable local drug delivery system and its effect on Porphyromonas gingivalis isolates: An in vitro study

2013 ◽  
Vol 17 (4) ◽  
pp. 429 ◽  
Author(s):  
Ranganathan Vijayalashmi ◽  
SabithaManhalore Ravindranath ◽  
NadathurDoraiswamy Jayakumar ◽  
Padmalatha ◽  
SheejaH Vargheese ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Porphyromonas Gingivalis ◽  
Delivery System ◽  
In Vitro Study ◽  
Local Drug Delivery ◽  
Local Drug Delivery System ◽  
Kinetics Of

scholarly journals Fibrin glue as a local drug-delivery system for bacteriophage PA5

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Evgenii Rubalskii ◽  
Stefan Ruemke ◽  
Christina Salmoukas ◽  
Andrey Aleshkin ◽  
Svetlana Bochkareva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Fibrin Glue ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Local Drug Delivery System

Chylomicrons-Simulating Sustained Drug Release in Mesenteric Lymphatics for the Treatment of Crohn’s-Like Colitis

2020 ◽  
Author(s):  
Yi Yin ◽  
Jingjing Yang ◽  
Yongchun Pan ◽  
Zhen Guo ◽  
Yanfeng Gao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lymphatic System ◽  
Intestinal Inflammation ◽  
Lymphatic Vessels ◽  
Experimental Colitis ◽  
Therapeutic Effects ◽  
Sustained Drug Release

Abstract Background and Aims Alteration to both the structures and functions of mesenteric lymphatic vessels is a typical hallmark of Crohn’s disease [CD]. Dysfunctional lymphatics was observed in patients with both CD and experimental colitis, suggesting mesenteric lymphatics could be potential therapeutic targets. This study aimed to develop a nano-delivery system which can enhance drug delivery in mesenteric lymphatic tissue [MLT] and evaluate the therapeutic effects in Crohn’s colitis. Methods We designed a mesoporous silica nanoparticle [MSN] conjugated with long-chain fatty acid [LMSN] and covered with enteric coating [ELMSN] which can be specifically transported via the mesenteric lymphatic system. The therapeutic efficacy of laquinimod-loaded nanoparticles [LAQ@ELMSN] was evaluated in the well-established interleukin [IL]-10−/− spontaneous experimental colitis. Results ELMSNs induced sustainable drug release that markedly increased drug concentration in MLT. In experimental colitis, the lymphatics-targeting drug delivery system suppressed lymphangitis and promoted lymphatic drainage. The downregulation of pro-inflammatory cytokines and the downstream NF-κB-related proteins efficiently inhibited lymphangiogenesis and restored tight junctions of mesenteric lymphatic vessels [MLVs]. LAQ@ELMSN showed a superior therapeutic effect in ameliorating intestinal inflammation compared with free drug administration. Alteration of gut microbiota and metabolites in experimental colitis was also reversed by LAQ@ELMSN. Conclusion Our study demonstrates a convenient, orally administered drug delivery system which enhances drug release in MLT. The results confirm the contribution of the mesenteric lymphatic system to the pathogenesis of gut inflammation and shed light on the application of lymphatics-targeting drug delivery therapy as a potential therapeutic strategy for CD treatment.

Highly uniform self-assembled microspheres from single macromolecule self-recognition for enhanced cancer immunotherapy

2020 ◽  
Vol 56 (64) ◽  
pp. 9190-9193
Author(s):  
Xin Shen ◽  
Zhenxia Zhou ◽  
Dongmei Qi ◽  
Yanchao Li ◽  
Zhiying Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Immunotherapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Self Recognition ◽  
Self Assembled ◽  
Local Drug Delivery System ◽  
Highly Uniform ◽  
Single Macromolecule

Self-assembled highly uniform microspheres has been developed as a local drug delivery system for effective synergistic immunotherapy.

A Novel Controlled Local Drug Delivery System for Inner Ear Disease

2008 ◽  
Vol 118 (4) ◽  
pp. 706-711 ◽  
Author(s):  
David P. Paulson ◽  
Waleed Abuzeid ◽  
Hao Jiang ◽  
Tomoyuki Oe ◽  
Bert W. O'Malley ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Inner Ear Disease ◽  
Local Drug Delivery System

scholarly journals Chitosan Films: A Potential Local Drug Delivery System for Antibiotics

2008 ◽  
Vol 466 (6) ◽  
pp. 1377-1382 ◽  
Author(s):  
Scott P. Noel ◽  
Harry Courtney ◽  
Joel D. Bumgardner ◽  
Warren O. Haggard
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Chitosan Films ◽  
Local Drug Delivery System
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