One-step green hydrothermal synthesis of biocompatible graphene/TiO2 nanocomposites for non-enzymatic H2O2 detection and their cytotoxicity effects on human keratinocyte and lung fibroblast cells

2018 ◽  
Vol 6 (8) ◽  
pp. 1195-1206 ◽  
Author(s):  
Qi Yan Siew ◽  
Shiau Ying Tham ◽  
Hwei-San Loh ◽  
Poi Sim Khiew ◽  
Wee Siong Chiu ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Lung Fibroblast ◽  
Electrochemical Sensing ◽  
Fibroblast Cells ◽  
Human Keratinocyte ◽  
H2o2 Detection ◽  
One Step ◽  
Good Biocompatibility ◽  
Sensing Application ◽  
Cytotoxicity Effects

A simple, safe, and efficient approach to synthesise graphene/titanium dioxide (G/TiO2) nanocomposites with potential in electrochemical sensing application and relatively good biocompatibility to human cells.

A novel one step synthesis of graphene via sonochemical-assisted solvent exfoliation approach for electrochemical sensing application

2014 ◽  
Vol 249 ◽  
pp. 270-278 ◽  
Author(s):  
Joanna Su Yuin Chia ◽  
Michelle T.T. Tan ◽  
Poi Sim Khiew ◽  
Jit Kai Chin ◽  
Hingwah Lee ◽  
...  
Keyword(s):  
Electrochemical Sensing ◽  
One Step ◽  
Sensing Application

Design of Arylsulfonylhydrazones as Potential FabH Inhibitors: Synthesis, Antimicrobial Evaluation and Molecular Docking

2019 ◽  
Vol 15 ◽  
Author(s):  
Thais Batista Fernandes ◽  
Natanael Dante Segretti ◽  
Felipe Rebello Lourenço ◽  
Thalita Marcílio Cândido ◽  
André Rolim Baby ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Molecular Docking ◽  
Antimicrobial Agents ◽  
Acyl Carrier Protein ◽  
Condensation Reaction ◽  
Lung Fibroblast ◽  
Fibroblast Cells ◽  
Human Lung Fibroblast ◽  
Persistent Problem ◽  
E Coli

Background: Antimicrobial resistance is a persistent problem about infections treatment and carries needing for develop new antimicrobial agents. Inhibiting of bacterial β-ketoacyl acyl carrier protein synthase III (FabH), which catalyzes the condensation reaction between a CoA-attached acetyl group and an ACP-attached malonyl group in bacteria is an interesting strategy to find new antibacterial agents. Objective: The aim of this work was to design and synthesize arylsulfonylhydrazones potentially FabH inhibitors and evaluate their antimicrobial activity. Methods: MIC50 of sulfonylhydrazones against E. coli and S. aureus was determined. Antioxidant activity was evaluated by DPPH (1-1’-diphenyl-2-picrylhydrazyl) assay and cytotoxicity against LL24 lung fibroblast cells was verified by MTT method. Principal component analysis (PCA) was performed in order to suggest a structure-activity relationship. Molecular docking allowed to propose sulfonylhydrazones interactions with FabH. Results: The most active compound showed activity against S. aureus and E. coli, with MIC50 = 0.21 and 0.44 µM, respectively. PCA studies correlated better activity to lipophilicity and molecular docking indicated that sulfonylhydrazone moiety is important to hydrogen-bond with FabH while methylcatechol ring performs π-π stacking interaction. The DPPH assay revealed that some sulfonylhydrazones derived from the methylcatechol series had antioxidant activity. None of the evaluated compounds was cytotoxic to human lung fibroblast cells, suggesting that the compounds might be considered safe at the tested concentration. Conclusion: Arylsufonylhydrazones is a promising scaffold to be explored for design of new antimicrobial agents.

Heat Treatment-Based One-Step Preparation of Highly Concentrated, Well-Stable Silver Colloids that Can Form Stable Films on Bare Electrodes for H2O2 Detection

2012 ◽  
Vol 8 (3) ◽  
pp. 335-342 ◽  
Author(s):  
Xuping Sun ◽  
Xiaoyun Qin ◽  
Jianming Hu ◽  
Yonglan Luo ◽  
Wenbo Lu ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Silver Colloids ◽  
H2o2 Detection ◽  
One Step

Biocompatible peptide hydrogels with excellent antibacterial and catalytic properties for electrochemical sensing application

2021 ◽  
Vol 1154 ◽  
pp. 338295
Author(s):  
Wenqi Wang ◽  
Rui Han ◽  
Kai Tang ◽  
Shuju Zhao ◽  
Caifeng Ding ◽  
...  
Keyword(s):  
Catalytic Properties ◽  
Electrochemical Sensing ◽  
Sensing Application ◽  
Peptide Hydrogels

Photocatalytic Activity of W-Doped TiO2 Nanopowders

2008 ◽  
Vol 11 (1) ◽  
Author(s):  
Katarzyna A. Michalow ◽  
Andri Vital ◽  
Andre Heel ◽  
Thomas Graule ◽  
Felix A. Reifler ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Photocatalytic Activity ◽  
Specific Surface ◽  
Dopant Concentration ◽  
Flame Spray ◽  
Titanium Tetra Isopropoxide ◽  
Flame Spray Synthesis ◽  
One Step ◽  
Tio2 Nanopowders ◽  
Doped Titanium Dioxide

AbstractPolycrystalline tungsten-doped titanium dioxide nanopowders within a dopant concentration of 0-1 at.% were prepared by a one-step flame spray synthesis (FSS). Mixtures of titanium tetra-isopropoxide dissolved in ethanol and tungsten hexacarbonyl solubilized in tetrahydrofuran were used as precursors. The specific surface area (SSA) of the powders was between 40 and 130 m

Ternary Hybrid γ-Fe2O3/CrVI/Amine Oxidase Nanostructure for Electrochemical Sensing: Application for Polyamine Detection in Tumor Tissue

2016 ◽  
Vol 22 (20) ◽  
pp. 6846-6852 ◽  
Author(s):  
Emanuela Bonaiuto ◽  
Massimiliano Magro ◽  
Davide Baratella ◽  
Petr Jakubec ◽  
Elisabetta Sconcerle ◽  
...  
Keyword(s):  
Tumor Tissue ◽  
Amine Oxidase ◽  
Electrochemical Sensing ◽  
Sensing Application
Sign in / Sign up

Export Citation Format

Share Document