Quenched hexacene optoacoustic nanoparticles

2018 ◽  
Vol 6 (1) ◽  
pp. 44-55 ◽  
Author(s):  
Antonio Nunes ◽  
Vikram J. Pansare ◽  
Nicolas Beziere ◽  
Argiris Kolokithas Ntoukas ◽  
Josefine Reber ◽  
...  
Keyword(s):  
Biomedical Imaging ◽  
Imaging Agents ◽  
Optoacoustic Imaging ◽  
Flash Nanoprecipitation ◽  
Strong Signal ◽  
The Creation

Flash NanoPrecipitation allows for the creation of optoacoustic imaging agents with tunable size and strong signal for biomedical imaging and therapy.

Ultrasmall Europium, Gadolinium, and Dysprosium Oxide Nanoparticles: Polyol Synthesis, Properties, and Biomedical Imaging Applications

2020 ◽  
Vol 20 (17) ◽  
pp. 1767-1780 ◽  
Author(s):  
Huan Yue ◽  
Ja Young Park ◽  
Yongmin Chang ◽  
Gang Ho Lee
Keyword(s):  
Contrast Agents ◽  
In Vivo Imaging ◽  
Biomedical Imaging ◽  
Mri Contrast Agents ◽  
Polyol Synthesis ◽  
Imaging Agents ◽  
Bibliographic Databases ◽  
Mri Contrast ◽  
X Ray

Imaging agents are crucial in diagnosing diseases. Ultrasmall lanthanide oxide (Ln2O3) nanoparticles (NPs) (Ln = Eu, Gd, and Dy) are promising materials as high-performance imaging agents because of their excellent magnetic, optical, and X-ray attenuation properties which can be applied as magnetic resonance imaging (MRI), fluorescence imaging (FI), and X-ray computed tomography (CT) agents, respectively. Ultrasmall Ln2O3 NPs (Ln = Eu, Gd, and Dy) are reviewed here. The reviewed topics include polyol synthesis, characterization, properties, and biomedical imaging applications of ultrasmall Ln2O3 NPs. Recently published papers were used as bibliographic databases. A polyol method is a simple and efficient one-pot synthesis for preparing ultrasmall Ln2O3 NPs. Ligand-coated ultrasmall Ln2O3 NPs have good colloidal stability, biocompatibility, and renal excretion ability suitable for in vivo imaging applications. Ultrasmall Eu2O3 NPs display photoluminescence in the red region suitable for use as FI agents. Ultrasmall Gd2O3 NPs have r1 values higher than those of commercial molecular contrast agents and r2/r1 ratios close to 1, which make them eligible for use as T1 MRI contrast agents. Ultrasmall Dy2O3 NPs exhibit high r2 and negligible r1 values, which make them suitable for use as T2 MRI contrast agents. All ultrasmall Ln2O3 NPs have high X-ray attenuation powers which make them suitable for use as CT contrast agents. Unmixed, mixed, or doped ultrasmall Ln2O3 NPs with different Ln are extremely useful for in vivo imaging applications in MRI, CT, FI, MRI-CT, MRI-FI, CT-FI, and MRI-CT-FI.

scholarly journals Recent Advances in Higher-Order, Multimodal, Biomedical Imaging Agents

Small ◽  
2015 ◽  
Vol 11 (35) ◽  
pp. 4445-4461 ◽  
Author(s):  
James Rieffel ◽  
Upendra Chitgupi ◽  
Jonathan F. Lovell
Keyword(s):  
Biomedical Imaging ◽  
Higher Order ◽  
Imaging Agents ◽  
Recent Advances

One Approach for Two: Toward the Creation of Near-Infrared Imaging Agents and Rapid Screening of Lanthanide(III) Ion Sensitizers Using Polystyrene Nanobeads

2019 ◽  
Vol 2 (4) ◽  
pp. 1667-1675 ◽  
Author(s):  
Ivana Martinić ◽  
Svetlana V. Eliseeva ◽  
Guillaume Collet ◽  
Tian-Yi Luo ◽  
Nathaniel Rosi ◽  
...  
Keyword(s):  
Near Infrared ◽  
Infrared Imaging ◽  
Rapid Screening ◽  
Imaging Agents ◽  
Near Infrared Imaging ◽  
The Creation

CHARACTERIZATION AND TOXICITY OF CARBON DOT-POLY(LACTIC-CO-GLYCOLIC ACID) NANOCOMPOSITES FOR BIOMEDICAL IMAGING

Nano LIFE ◽  
2013 ◽  
Vol 03 (01) ◽  
pp. 1340002 ◽  
Author(s):  
C. JENNY DORCÉNA ◽  
KRISTI M. OLESIK ◽  
OLIVIA G. WETTA ◽  
JESSICA O. WINTER
Keyword(s):  
Renal Clearance ◽  
Biomedical Imaging ◽  
Glycolic Acid ◽  
Reticuloendothelial System ◽  
Imaging Agents ◽  
Fluorescent Nanoparticles ◽  
Mean Diameter ◽  
Available Carbon ◽  
Biological Environment

Semiconductor quantum dots (QDs) have achieved initial success as biomedical imaging agents. However, significant cytotoxicity in the biological environment prohibits their use in vivo. Here, we introduce nanocomposites composed of carbon dots (C-dots) in poly(lactic-co-glycolic acid) (PLGA) carriers as possible imaging agents for in vivo applications. An initial hurdle to clinical use is overcome by synthesizing C-dots with commercially available carbon black precursors, permitting scalable nanomanufacturing. These fluorescent nanoparticles, which have a mean diameter of ~1 nm, display a disordered graphitic structure. To overcome a second clinical hurdle (i.e., rapid renal clearance of nanoparticles <~6 nm in diameter), C-dots were encapsulated in biodegradable PLGA nanospheres. The resulting nanocomposites showed a mean diameter of 344 ± 23 nm, which should reduce renal clearance. With further optimization, nanocarriers could be optimized to sizes <200 nm to reduce accumulation in the reticuloendothelial system (RES). Toxicity of both C-dots and C-dot-PLGA nanocomposites was evaluated using HepG2 liver cell lines. Unlike QDs, which can induce toxicological responses at concentrations as low as 0.005 mg/mL, C-dots exhibited cytotoxicity at concentrations greater than 0.2 mg/mL, while their derived nanocomposites did not exhibit cytotoxicity at any concentration tested (i.e., 0.02 mg/mL, 0.1 mg/mL and 0.2 mg/mL).

scholarly journals Microwave-assisted synthesis of highly crystalline, multifunctional iron oxide nanocomposites for imaging applications

RSC Advances ◽  
2016 ◽  
Vol 6 (87) ◽  
pp. 83520-83528 ◽  
Author(s):  
Marc J. Williams ◽  
Enrique Sánchez ◽  
Esther Rani Aluri ◽  
Fraser J. Douglas ◽  
Donald A. MacLaren ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Biomedical Imaging ◽  
Single Step ◽  
Imaging Agents ◽  
Microwave Assisted Synthesis ◽  
Magnetic Nanocomposites ◽  
Synthetic Methodology ◽  
Microwave Assisted

We report a single-step, microwave-assisted approach for the preparation of multifunctional magnetic nanocomposites. We demonstrate the link between synthetic methodology and the functionality of the nanocomposites as biomedical imaging agents.

The role of affect in feelings of obligation

2020 ◽  
Vol 43 ◽  
Author(s):  
Stefen Beeler-Duden ◽  
Meltem Yucel ◽  
Amrisha Vaish
Keyword(s):  
Positive Emotions ◽  
The Creation ◽  
Sense Of Obligation

Abstract Tomasello offers a compelling account of the emergence of humans’ sense of obligation. We suggest that more needs to be said about the role of affect in the creation of obligations. We also argue that positive emotions such as gratitude evolved to encourage individuals to fulfill cooperative obligations without the negative quality that Tomasello proposes is inherent in obligations.

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