Smart multifunctional polyurethane microcapsules for the quick release of anticancer drugs in BGC 823 and HeLa tumor cells

2017 ◽  
Vol 5 (48) ◽  
pp. 9477-9481 ◽  
Author(s):  
Yuqing Niu ◽  
Florian J. Stadler ◽  
Tao He ◽  
Xingcai Zhang ◽  
Yingjie Yu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Cell ◽  
Real Time ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Real Time Monitoring ◽  
Triggered Release ◽  
Quick Release ◽  
Cell Internalization

Smart fluorescent polyurethane microcapsules with high tumor cell internalization, triggered release were developed for precision real-time monitoring cancer therapy.

Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy

2020 ◽  
Vol 27 (13) ◽  
pp. 2118-2132 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Hakan Ozben ◽  
Ferhat Hanikoglu ◽  
Tomris Ozben
Keyword(s):  
Oxidative Stress ◽  
Drug Resistance ◽  
Side Effects ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Chemotherapeutic Agents ◽  
Oxidation Reactions ◽  
Hybrid Compounds ◽  
Induced Apoptosis

: Elevated Reactive Oxygen Species (ROS) generated by the conventional cancer therapies and the endogenous production of ROS have been observed in various types of cancers. In contrast to the harmful effects of oxidative stress in different pathologies other than cancer, ROS can speed anti-tumorigenic signaling and cause apoptosis of tumor cells via oxidative stress as demonstrated in several studies. The primary actions of antioxidants in cells are to provide a redox balance between reduction-oxidation reactions. Antioxidants in tumor cells can scavenge excess ROS, causing resistance to ROS induced apoptosis. Various chemotherapeutic drugs, in their clinical use, have evoked drug resistance and serious side effects. Consequently, drugs having single-targets are not able to provide an effective cancer therapy. Recently, developed hybrid anticancer drugs promise great therapeutic advantages due to their capacity to overcome the limitations encountered with conventional chemotherapeutic agents. Hybrid compounds have advantages in comparison to the single cancer drugs which have usually low solubility, adverse side effects, and drug resistance. This review addresses two important treatments strategies in cancer therapy: oxidative stress induced apoptosis and hybrid anticancer drugs.

Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry

Head & Neck ◽  
2013 ◽  
Vol 36 (8) ◽  
pp. 1207-1215 ◽  
Author(s):  
Mazen A. Juratli ◽  
Mustafa Sarimollaoglu ◽  
Eric R. Siegel ◽  
Dmitry A. Nedosekin ◽  
Ekaterina I. Galanzha ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Tumor Cell ◽  
Real Time ◽  
Circulating Tumor Cell ◽  
Real Time Monitoring ◽  
Cell Release

A Unique Self-Reporting Photosensitizer Enabling Simultaneous Photodynamic Therapy and Real-Time Monitoring Phototheranostic Process in a Dynamic Dual-Color Mode

2021 ◽  
Author(s):  
Dong-Hui Wang ◽  
Li-Jian Chen ◽  
Xu Zhao ◽  
Xiu-Ping Yan
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Real Time ◽  
Small Molecule ◽  
Therapeutic Efficacy ◽  
Real Time Monitoring ◽  
Dual Color

Phototheranostics has attracted great interest in cancer therapy. Small-molecule self-reporting photosensitizers, one kind of idea agents in phototheranostics, enable simultaneous photodynamic therapy (PDT) and feedback of therapeutic efficacy. However, previous...

scholarly journals Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1905
Author(s):  
Irina S. R. Rio ◽  
Ana Rita O. Rodrigues ◽  
Juliana M. Rodrigues ◽  
Maria-João R. P. Queiroz ◽  
R. C. Calhelha ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Cells ◽  
Human Tumor ◽  
Plasmonic Nanoparticles ◽  
Core Shell ◽  
Triggered Release ◽  
Shell Nanoparticles ◽  
Visible Absorption ◽  
The Core ◽  
Average Size

Liposome-like nanoarchitectures containing manganese ferrite nanoparticles covered or decorated with gold were developed for application in dual cancer therapy, combining chemotherapy and photothermia. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The average size of the gold-decorated nanoparticles was 26.7 nm for MnFe2O4 with 5–7 nm gold nanospheres. The average size of the core/shell nanoparticles was 28.8 nm for the magnetic core and around 4 nm for the gold shell. Two new potential antitumor fluorescent drugs, tricyclic lactones derivatives of thienopyridine, were loaded in these nanosystems with very high encapsulation efficiencies (higher than 98%). Assays in human tumor cell lines demonstrate that the nanocarriers do not release the antitumor compounds in the absence of irradiation. Moreover, the nanosystems do not cause any effect on the growth of primary (non-tumor) cells (with or without irradiation). The drug-loaded systems containing the core/shell magnetic/plasmonic nanoparticles efficiently inhibit the growth of tumor cells when irradiated with red light, making them suitable for a triggered release promoted by irradiation.

scholarly journals Anticancer Drugs Up-regulate HspBP1 and Thereby Antagonize the Prosurvival Function of Hsp70 in Tumor Cells

2007 ◽  
Vol 282 (49) ◽  
pp. 35430-35439 ◽  
Author(s):  
Susumu Tanimura ◽  
A-i Hirano ◽  
Junya Hashizume ◽  
Masahiro Yasunaga ◽  
Takumi Kawabata ◽  
...  
Keyword(s):  
Cell Death ◽  
Heat Shock ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Ectopic Expression ◽  
Biological Significance ◽  
Cell Types ◽  
Molar Ratio ◽  
Lysosomal Membranes

The 70-kDa heat shock protein (Hsp70) is up-regulated in a wide variety of tumor cell types and contributes to the resistance of these cells to the induction of cell death by anticancer drugs. Hsp70 binding protein 1 (HspBP1) modulates the activity of Hsp70 but its biological significance has remained unclear. We have now examined whether HspBP1 might interfere with the prosurvival function of Hsp70, which is mediated, at least in part, by inhibition of the death-associated permeabilization of lysosomal membranes. HspBP1 was found to be expressed at a higher level than Hsp70 in all normal and tumor cell types examined. Tumor cells with a high HspBP1/Hsp70 molar ratio were more susceptible to anticancer drugs than were those with a low ratio. Ectopic expression of HspBP1 enhanced this effect of anticancer drugs in a manner that was both dependent on the ability of HspBP1 to bind to Hsp70 and sensitive to the induction of Hsp70 by mild heat shock. Furthermore, anticancer drugs up-regulated HspBP1 expression, whereas prevention of such up-regulation by RNA interference reduced the susceptibility of tumor cells to anticancer drugs. Overexpression of HspBP1 promoted the permeabilization of lysosomal membranes, the release of cathepsins from lysosomes into the cytosol, and the activation of caspase-3 induced by anticancer drugs. These results suggest that HspBP1, by antagonizing the prosurvival activity of Hsp70, sensitizes tumor cells to cathepsin-mediated cell death.

Fully automated, on-site isolation of cfDNA from whole blood for cancer therapy monitoring

Lab on a Chip ◽  
2018 ◽  
Vol 18 (9) ◽  
pp. 1320-1329 ◽  
Author(s):  
Chi-Ju Kim ◽  
Juhee Park ◽  
Vijaya Sunkara ◽  
Tae-Hyeong Kim ◽  
Yongjin Lee ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Cancer Therapy ◽  
Real Time ◽  
Whole Blood ◽  
Therapy Monitoring ◽  
Real Time Monitoring ◽  
Site Isolation ◽  
Mutation Status ◽  
Fully Integrated

Fully integrated lab-on-a-disc for cfDNA isolation allows real-time monitoring of tumor mutation status during targeted therapy.

Dual-sensitive and biodegradable core-crosslinked HPMA copolymer–doxorubicin conjugate-based nanoparticles for cancer therapy

2017 ◽  
Vol 8 (15) ◽  
pp. 2370-2380 ◽  
Author(s):  
Manling Tang ◽  
Minglu Zhou ◽  
Yuan Huang ◽  
Jiaju Zhong ◽  
Zhou Zhou ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Blood Circulation ◽  
Hpma Copolymer

The nanoplatform of biosafe crosslinked copolymer-NPs efficiently delivers anticancer drugs to tumor cellsviablood circulation.

scholarly journals Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry

2017 ◽  
Vol 492 (3) ◽  
pp. 507-512 ◽  
Author(s):  
Nathan A. Koonce ◽  
Mazen A. Juratli ◽  
Chengzhong Cai ◽  
Mustafa Sarimollaoglu ◽  
Yulian A. Menyaev ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Tumor Cell ◽  
Real Time ◽  
Circulating Tumor Cell ◽  
Real Time Monitoring ◽  
In Vivo Flow Cytometry
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