Controlled release of BMP-2 from a collagen-mimetic peptide-modified silk fibroin–nanohydroxyapatite scaffold for bone regeneration

2017 ◽  
Vol 5 (44) ◽  
pp. 8770-8779 ◽  
Author(s):  
Jiachen Sun ◽  
Yanxia Zhang ◽  
Bin Li ◽  
Yong Gu ◽  
Liang Chen
Keyword(s):  
Controlled Release ◽  
Bone Regeneration ◽  
Silk Fibroin ◽  
Mimetic Peptide

Controlled release of BMP-2 from a collagen-mimetic peptide-modified scaffold for bone regeneration.

scholarly journals Photocuring Hyaluronic Acid/Silk Fibroin Hydrogel Containing Curcumin Loaded CHITOSAN Nanoparticles for the Treatment of MG-63 Cells and ME3T3-E1 Cells

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2302
Author(s):  
Qingwen Yu ◽  
Zhiyuan Meng ◽  
Yichao Liu ◽  
Zehao Li ◽  
Xing Sun ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Bone Regeneration ◽  
Water Uptake ◽  
Silk Fibroin ◽  
Bone Repair ◽  
Ph Value ◽  
Chitosan Nanoparticles ◽  
Vitro Assay ◽  
Long Term Treatment

After an osteosarcoma excision, recurrence and bone defects are significant challenges for clinicians. In this study, the curcumin (Cur) loaded chitosan (CS) nanoparticles (CCNP) encapsulated silk fibroin (SF)/hyaluronic acid esterified by methacrylate (HAMA) (CCNPs-SF/HAMA) hydrogel for the osteosarcoma therapy and bone regeneration was developed by photocuring and ethanol treatment. The micro or nanofibers networks were observed in the CCNPs-SF/HAMA hydrogel. The FTIR results demonstrated that alcohol vapor treatment caused an increase in β-sheets of SF, resulting in the high compression stress and Young’s modulus of CCNPs-SF/HAMA hydrogel. According to the water uptake analysis, SF caused a slight decrease in water uptake of CCNPs-SF/HAMA hydrogel while CCNPs could enhance the water uptake of it. The swelling kinetic results showed that both the CCNPs and the SF increased the swelling ratio of CCNPs-SF/HAMA hydrogel. The accumulative release profile of CCNPs-SF/HAMA hydrogel showed that the release of Cur from CCNPs-SF/HAMA hydrogel was accelerated when pH value was decreased from 7.4 to 5.5. Besides, compared with CCNPs, the CCNPs-SF/HAMA hydrogel had a more sustainable drug release, which was beneficial for the long-term treatment of osteosarcoma. In vitro assay results indicated that CCNPs-SF/HAMA hydrogel with equivalent Cur concentration of 150 μg/mL possessed both the effect of anti-cancer and promoting the proliferation of osteoblasts. These results suggest that CCNPs-SF/HAMA hydrogel with superior physical properties and the bifunctional osteosarcoma therapy and bone repair may be an excellent candidate for local cancer therapy and bone regeneration.

Silk-based hybrid microfibrous mats as guided bone regeneration membranes

2021 ◽  
Author(s):  
Mi Wu ◽  
Zhengyi Han ◽  
Wen Liu ◽  
Jinrong Yao ◽  
Bingjiao Zhao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cell Adhesion ◽  
Bone Regeneration ◽  
Silk Fibroin ◽  
Guided Bone Regeneration ◽  
Regenerated Silk Fibroin ◽  
Marrow Mesenchymal Stem Cells ◽  
Cell Adhesion And Proliferation

LAPONITE® (LAP) nanoplatelets were incorporated within a regenerated silk fibroin (RSF) microfibrous mat via electrospinning, which exhibited better cell adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs) than the pristine RSF ones.

Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue engineering approach

2021 ◽  
Vol 17 (1) ◽  
pp. 015003
Author(s):  
Lya Piaia ◽  
Simone S Silva ◽  
Joana M Gomes ◽  
Albina R Franco ◽  
Emanuel M Fernandes ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Cellular Proliferation ◽  
Mechanical Performance ◽  
Tissue Growth ◽  
Polymeric Scaffolds ◽  
Bioactive Agents

Abstract Bone regeneration and natural repair are long-standing processes that can lead to uneven new tissue growth. By introducing scaffolds that can be autografts and/or allografts, tissue engineering provides new approaches to manage the major burdens involved in this process. Polymeric scaffolds allow the incorporation of bioactive agents that improve their biological and mechanical performance, making them suitable materials for bone regeneration solutions. The present work aimed to create chitosan/beta-tricalcium phosphate-based scaffolds coated with silk fibroin and evaluate their potential for bone tissue engineering. Results showed that the obtained scaffolds have porosities up to 86%, interconnectivity up to 96%, pore sizes in the range of 60–170 μm, and a stiffness ranging from 1 to 2 MPa. Furthermore, when cultured with MC3T3 cells, the scaffolds were able to form apatite crystals after 21 d; and they were able to support cell growth and proliferation up to 14 d of culture. Besides, cellular proliferation was higher on the scaffolds coated with silk. These outcomes further demonstrate that the developed structures are suitable candidates to enhance bone tissue engineering.

Clinical study of guided bone regeneration of extracted socket with PLA/PGA membrane and silk fibroin membrane

2009 ◽  
Vol 39 (2) ◽  
pp. 129 ◽  
Author(s):  
Woo-Jin Hwang ◽  
Seong-nyum Jeong ◽  
Yun-Sang Kim ◽  
Sung-Hee Pi ◽  
Hyung-Keun You ◽  
...  
Keyword(s):  
Clinical Study ◽  
Bone Regeneration ◽  
Silk Fibroin ◽  
Guided Bone Regeneration

Mechanically enhanced lipo-hydrogel with controlled release of multi-type drugs for bone regeneration

2018 ◽  
Vol 12 ◽  
pp. 294-308 ◽  
Author(s):  
Ruoyu Cheng ◽  
Yufei Yan ◽  
Han Liu ◽  
Hao Chen ◽  
Guoqing Pan ◽  
...  
Keyword(s):  
Controlled Release ◽  
Bone Regeneration

scholarly journals Silk fibroin micro-particle scaffolds with superior compression modulus and slow bioresorption for effective bone regeneration

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Anuya Nisal ◽  
Raeesa Sayyad ◽  
Prachi Dhavale ◽  
Bhakti Khude ◽  
Rucha Deshpande ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Silk Fibroin ◽  
Compression Modulus

Silk fibroin double-layer microneedles for the encapsulation and controlled release of triptorelin

2021 ◽  
pp. 121433
Author(s):  
Xiaoyan Lu ◽  
Yiying Sun ◽  
Meishan Han ◽  
Daoyuan Chen ◽  
Aiping Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Double Layer ◽  
Silk Fibroin
Sign in / Sign up

Export Citation Format

Share Document