Computational investigation of metal organic frameworks for storage and delivery of anticancer drugs

2017 ◽  
Vol 5 (35) ◽  
pp. 7342-7351 ◽  
Author(s):  
Ilknur Erucar ◽  
Seda Keskin
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Computational Investigation ◽  
Drug Molecules ◽  
Metal Organic

The potential of metal organic frameworks (MOFs) as binary drug carriers was computationally investigated for storage and delivery of two anticancer drug molecules, methotrexate (MTX) and 5-fluorouracil (5-FU).

scholarly journals Biocompatible Fe-Based Micropore Metal-Organic Frameworks as Sustained-Release Anticancer Drug Carriers

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2490 ◽  
Author(s):  
Xin Leng ◽  
Xiaoxv Dong ◽  
Wenping Wang ◽  
Na Sai ◽  
Chunjing Yang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Anticancer Drug ◽  
High Performance ◽  
Hot Spot ◽  
Metal Organic Frameworks ◽  
Annexin V ◽  
Drug Carriers ◽  
Design And Synthesis ◽  
Metal Organic

Sustained-release preparation is a hot spot in antitumor drug research, where the first task is to select suitable drug carriers. Research has revealed that carboxylic acid iron metal–organic frameworks (MOFs), constructed from iron (Fe) ions and terephthalic acid, are nontoxic and biocompatible. Due to the breathing effect, the skeleton of this mesoporous material is flexible and can reversibly adapt its pore size through drug adsorption. Therefore, we chose one kind of Fe-MOF, MIL-53(Fe), as a carrier for the anticancer drug oridonin (Ori). In this work, we report the design and synthesis of MIL-53(Fe) and explore its ability as a transport vehicle to deliver Ori. MIL-53(Fe) is characterized by scanning electron microscopy and X-ray powder diffraction. A loading capacity of 56.25 wt % was measured by high performance liquid chromatography. This carrier was safe and nontoxic (cell viability > 95.27%), depending on the results of 3-(4,5-dimethylthiazol-2-yl)--2,5-diphenyltetrazolium bromide assays, lactate dehydrogenase assays, and Annexin V-fluoresce isothiocyanate/propidium iodide double-staining assays. After loading the drug, the structure of the MIL-53(Fe) was not destroyed, and Ori was amorphous in MIL-53(Fe). Based on an analysis of the Ori release profile, results suggest that it lasts for more than seven days in vitro. The cumulative release rate of Ori at the seventh day was about 82.23% and 91.75% in phosphate buffer saline solution at 37 °C under pH 7.2 and pH 5.5, respectively. HepG2 cells were chosen to study the cytotoxicity of Ori@MIL-53(Fe), and the results show that the anticancer ratio of Ori@MIL-53(Fe) system reaches 90.62%. Thus, MIL-53 can be used as a carrier for anticancer drugs and Ori@MIL-53(Fe) is a promising sustained-release drug delivery system for the cancer therapy.

Screening of bio-compatible metal–organic frameworks as potential drug carriers using Monte Carlo simulations

2014 ◽  
Vol 2 (7) ◽  
pp. 766-774 ◽  
Author(s):  
María C. Bernini ◽  
David Fairen-Jimenez ◽  
Marcelo Pasinetti ◽  
Antonio J. Ramirez-Pastor ◽  
Randall Q. Snurr
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Potential Drug ◽  
Metal Organic

scholarly journals The application of metal-organic frameworks in electrode materials for lithium–ion and lithium–sulfur batteries

2019 ◽  
Vol 6 (7) ◽  
pp. 190634 ◽  
Author(s):  
Ji Ping Zhu ◽  
Xiu Hao Wang ◽  
Xiu Xiu Zuo
Keyword(s):  
Electrode Materials ◽  
Gas Adsorption ◽  
Metal Organic Frameworks ◽  
Lithium Ion ◽  
Drug Carriers ◽  
Large Specific Surface Area ◽  
Lithium Sulfur Batteries ◽  
Battery Electrode ◽  
Metal Organic ◽  
Lithium Sulfur

Metal-organic frameworks (MOFs) have gained increased attention due to their unique features, including tunable pore sizes, controllable structures and a large specific surface area. In addition to their application in gas adsorption and separation, hydrogen storage, optics, magnetism and organic drug carriers, MOFs also can be used in batteries and supercapacitors which have attracted the researcher's attention. Based on recent studies, this review describes the latest developments about MOFs as battery electrode materials which are used in lithium–ion and lithium–sulfur batteries.

One-pot synthesis of hierarchical-pore metal–organic frameworks for drug delivery and fluorescent imaging

CrystEngComm ◽  
2018 ◽  
Vol 20 (8) ◽  
pp. 1087-1093 ◽  
Author(s):  
Xuechuan Gao ◽  
Yuewu Wang ◽  
Guanfeng Ji ◽  
Ruixue Cui ◽  
Zhiliang Liu
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
Fluorescent Imaging ◽  
One Pot ◽  
One Pot Synthesis ◽  
Drug Molecules ◽  
Metal Organic ◽  
Hierarchical Pore

A one-pot process has been developed for the synthesis of hierarchical-pore metal–organic frameworks, aimed at loading large and small drug molecules simultaneously.

Folic Acid Functionalized Zirconium‐Based Metal–Organic Frameworks as Drug Carriers for Active Tumor‐Targeted Drug Delivery

2018 ◽  
Vol 24 (64) ◽  
pp. 17148-17154 ◽  
Author(s):  
Hong Dong ◽  
Gui‐Xin Yang ◽  
Xin Zhang ◽  
Xiang‐Bin Meng ◽  
Jing‐Li Sheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Targeted Drug Delivery ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Metal Organic ◽  
Targeted Drug

Experimental, Structural, and Computational Investigation of Mixed Metal–Organic Frameworks from Regioisomeric Ligands for Porosity Control

2020 ◽  
Vol 20 (8) ◽  
pp. 5338-5345 ◽  
Author(s):  
Dopil Kim ◽  
Hyeonbin Ha ◽  
Youngik Kim ◽  
Younghu Son ◽  
Jiyoon Choi ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Computational Investigation ◽  
Mixed Metal ◽  
Metal Organic

scholarly journals New insights into the degradation mechanism of metal-organic frameworks drug carriers

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
X. Li ◽  
L. Lachmanski ◽  
S. Safi ◽  
S. Sene ◽  
C. Serre ◽  
...  
Keyword(s):  
Degradation Mechanism ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Metal Organic

scholarly journals Metal–organic frameworks as potential drug carriers

2010 ◽  
Vol 14 (2) ◽  
pp. 262-268 ◽  
Author(s):  
Rachel C Huxford ◽  
Joseph Della Rocca ◽  
Wenbin Lin
Keyword(s):  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Potential Drug ◽  
Metal Organic
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