Litchi-like Fe3O4@Fe-MOF capped with HAp gatekeepers for pH-triggered drug release and anticancer effect

2017 ◽  
Vol 5 (43) ◽  
pp. 8600-8606 ◽  
Author(s):  
Yongmei Yang ◽  
Feng Xia ◽  
Ying Yang ◽  
Baoyou Gong ◽  
Anjian Xie ◽  
...  
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Magnetic Core ◽  
Ph Sensitive ◽  
Anticancer Effect ◽  
Porous Composite ◽  
Metal Organic ◽  
Triggered Drug Release ◽  
Organic Framework

A novel litchi-like porous composite composed of a magnetic core, a tunable metal–organic framework (MOF) shell and a pH-sensitive hydroxyapatite (HAp) gatekeeper was successfully fabricated in this work.

Thermal Stimuli-Triggered Drug Release from a Biocompatible Porous Metal-Organic Framework

2017 ◽  
Vol 23 (42) ◽  
pp. 10215-10221 ◽  
Author(s):  
Ke Jiang ◽  
Ling Zhang ◽  
Quan Hu ◽  
Qi Zhang ◽  
Wenxin Lin ◽  
...  
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Porous Metal ◽  
Metal Organic ◽  
Triggered Drug Release ◽  
Thermal Stimuli ◽  
Organic Framework

scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

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