Sustained subconjunctival delivery of cyclosporine A using thermogelling polymers for glaucoma filtration surgery

2017 ◽  
Vol 5 (31) ◽  
pp. 6400-6411 ◽  
Author(s):  
Jianguo Sun ◽  
Xi Liu ◽  
Yuan Lei ◽  
Mingyu Tang ◽  
Zhaoxing Dai ◽  
...  
Keyword(s):  
Delivery System ◽  
Cyclosporine A ◽  
Scar Formation ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Surgical Scar

We successfully developed a subconjunctival delivery system of CsA using an injectable thermogel to inhibit post-surgical scar formation after glaucoma filtration surgery.

scholarly journals Epigenetic Modification Prevents Excessive Wound Healing and Scar Formation After Glaucoma Filtration Surgery

2016 ◽  
Vol 57 (7) ◽  
pp. 3381 ◽  
Author(s):  
Ajay Sharma ◽  
Govindaraj Anumanthan ◽  
Marcos Reyes ◽  
Huiyi Chen ◽  
Jacob W. Brubaker ◽  
...  
Keyword(s):  
Wound Healing ◽  
Epigenetic Modification ◽  
Scar Formation ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery

scholarly journals Effects of rosiglitazone/PHBV drug delivery system on postoperative fibrosis in rabbit glaucoma filtration surgery model

Drug Delivery ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 812-819 ◽  
Author(s):  
Feng Zhang ◽  
Ke Liu ◽  
Zheng Pan ◽  
Mengdan Cao ◽  
Dengming Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Postoperative Fibrosis

Inhibition of Vascular Endothelial Growth Factor Reduces Scar Formation after Glaucoma Filtration Surgery

2009 ◽  
Vol 50 (11) ◽  
pp. 5217 ◽  
Author(s):  
Zhongqiu Li ◽  
Tine Van Bergen ◽  
Sara Van de Veire ◽  
Isabelle Van de Vel ◽  
Huberte Moreau ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Scar Formation ◽  
Vascular Endothelial ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Endothelial Growth Factor

The role of different VEGF isoforms in scar formation after glaucoma filtration surgery

2011 ◽  
Vol 93 (5) ◽  
pp. 689-699 ◽  
Author(s):  
Tine Van Bergen ◽  
Evelien Vandewalle ◽  
Sara Van de Veire ◽  
Mieke Dewerchin ◽  
Jean-Marie Stassen ◽  
...  
Keyword(s):  
Scar Formation ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Vegf Isoforms

Comparison of phaco time parameters in eyes with and without glaucoma filtration surgery due to pseudoexfoliation glaucoma

2021 ◽  
pp. 112067212110177
Author(s):  
Ayse Gul Kocak Altintas ◽  
Cagri Ilhan
Keyword(s):  
Clinical Characteristics ◽  
Pseudoexfoliation Glaucoma ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Mean Values ◽  
Time Parameters ◽  
The Mean ◽  
Group 2 ◽  
Surgical Manipulations ◽  
Phaco Time

Purpose: To compare the phaco time parameters including ultrasound time (UST), effective phaco time (EPT), and average phaco power (APP) in eyes with pseudoexfoliation glaucoma (PEG) and had or had not glaucoma filtration surgery. Methods: In this retrospective comparative study, Group 1 was constructed with 84 PEG patients who had not operated previously, and Group 2 was constructed with 49 PEG patients who had glaucoma filtration surgery. The mean values of UST, EPT, and APP were compared. The preoperative clinical characteristics and surgical manipulations were also compared. Results: The mean ages and male-to-female ratios of the groups were similar ( p > 0.05, for both). There was no difference in the preoperative clinical characteristics, including biometric values between the groups ( p > 0.05, for all). Some surgical manipulations, including pupillary stretching ( p = 0.004), pupillary membrane peeling ( p = 0.021), iris hook using ( p = 0.041), and capsular tension ring implantation ( p = 0.041), were significantly performed more commonly in Group 2. Although the mean UST and EPT values were similar ( p > 0.05, for both), the mean APP value was significantly lower in Group 2 ( p = 0.011). Conclusion: The lower APP parameter was observed in PEG patients having had glaucoma filtration surgery. Needing more surgical manipulation to overcome poor pupillary dilation and weak zonular instability can be a reason for this result.

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