Covalently-controlled drug delivery via therapeutic methacrylic tissue adhesives

2017 ◽  
Vol 5 (37) ◽  
pp. 7743-7755 ◽  
Author(s):  
Zoe M. Wright ◽  
Brian D. Holt ◽  
Stefanie A. Sydlik
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Controlled Release ◽  
Controlled Drug Delivery ◽  
Tissue Adhesives ◽  
Tunable Mechanical Properties

Therapeutic methacrylic (TMA) monomers lend local, covalently-controlled release of therapeutics, tunable mechanical properties, and increased cytocompatibility to cyanoacrylate medical adhesives.

Improvement of Optical and Mechanical Properties, and Controlled Release of Drug Delivery Powder Cosmetics

2019 ◽  
Vol 1 (3) ◽  
pp. 198-204
Author(s):  
Yasumasa Takao ◽  
Naoaki Toyoda ◽  
Tsuyoshi Asai ◽  
Toshihiko Okadera ◽  
Hiroyuki Asano
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Controlled Release ◽  
Optical And Mechanical Properties

Highly Glycerin-Loaded Natural Rubber Films Prepared by Casting Technique Using Different Solvents

2013 ◽  
Vol 844 ◽  
pp. 190-193 ◽  
Author(s):  
Pongsathorn Issarayungyuen ◽  
Wiwat Pichayakorn ◽  
Thawatchai Phaechamud
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tensile Strength ◽  
Natural Rubber ◽  
Porous Structure ◽  
Diethyl Ether ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Porous Structures ◽  
Casting Technique

The highly glycerin-loaded natural rubber (NR) films were fabricated by casting technique with different solvents including dichloromethane (DCM), diethyl ether and tetrahydrofuran (THF) with an addition of 75 phr glycerin. Their mechanical properties, wettability and topography were determined. The highly glycerin-loaded NR films exhibited the continuous porous structure which their tensile strength values decreased whereas their wettability was enhanced. Pore size of the glycerin-loaded NR films prepared by using DCM as a solvent was greatly larger than those of the systems prepared by using diethyl ether and THF, respectively. Some active compounds might be loaded into these modified porous structures of NR films and applied for controlled drug delivery systems.

scholarly journals Controlled release of entrapped nanoparticles from thermoresponsive hydrogels with tunable network characteristics

Soft Matter ◽  
2020 ◽  
Vol 16 (20) ◽  
pp. 4756-4766 ◽  
Author(s):  
Yi Wang ◽  
Zhen Li ◽  
Jie Ouyang ◽  
George Em Karniadakis
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Network Characteristics ◽  
Thermoresponsive Hydrogels ◽  
Smart Drug

Thermoresponsive hydrogels have been studied intensively for creating smart drug carriers and controlled drug delivery.

scholarly journals Osmotic controlled drug delivery system (OSMO technology) and its impact on diabetes care

2020 ◽  
Vol 9 (1) ◽  
pp. 303
Author(s):  
Rajesh Rajput ◽  
K. M. K. Prasanna Kumar ◽  
D. S. Arya ◽  
A. K. Das ◽  
A. H. Zargar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Delivery ◽  
Controlled Drug Delivery ◽  
Special Focus ◽  
Sustained Delivery ◽  
Oral Delivery System ◽  
Prolonged Duration

Recently, focus on the development of controlled release drug delivery system has increased, as existing drugs exhibit certain pharmacokinetic limitations. The major goal of designing sustained release formulations is to improve the drug performance by prolonged duration of drug action, decreased frequency of dosing and reduced side effects by using smallest quantity of drug administered by the most suitable route. Osmotic-controlled release oral delivery system (OSMO technology) is the most promising strategy based system for sustained delivery of drug. Drug can be delivered in a controlled manner over a long period of time by the process of osmosis. Osmotic drug delivery system appears to be a promising solution for the limitations of conventional extended release formulations by virtue of their distinguished technological features. The present review describes briefly about various controlled drug delivery systems with special focus on advantages of osmotic-controlled release oral delivery system related to diabetes therapy and improved compliance.

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