Novel PAN/PVP Janus ultrafine fiber membrane and its application for biphasic drug release

2017 ◽  
Vol 5 (27) ◽  
pp. 5390-5396 ◽  
Author(s):  
Yuting Geng ◽  
Pan Zhang ◽  
Qiutong Wang ◽  
Yangxiu Liu ◽  
Kai Pan
Keyword(s):  
Drug Release ◽  
Fiber Membrane ◽  
Ultrafine Fiber ◽  
Significant Attention

Materials with Janus structures have attracted significant attention in recent years.

Immobilization of lipase onto cellulose ultrafine fiber membrane for oil hydrolysis in high performance bioreactor

Cellulose ◽  
2011 ◽  
Vol 18 (6) ◽  
pp. 1563-1571 ◽  
Author(s):  
Peng-Cheng Chen ◽  
Xiao-Jun Huang ◽  
Fu Huang ◽  
Yang Ou ◽  
Ming-Rui Chen ◽  
...  
Keyword(s):  
High Performance ◽  
Fiber Membrane ◽  
Ultrafine Fiber ◽  
Oil Hydrolysis

Polycarprolactone ultrafine fiber membrane fabricated using a charge-reduced electrohydrodynamic process

2009 ◽  
Vol 17 (7) ◽  
pp. 533-537 ◽  
Author(s):  
GeunHyung Kim ◽  
Hyeon Yoon ◽  
HaengNam Lee ◽  
Gil-Moon Park ◽  
YoungHo Koh
Keyword(s):  
Fiber Membrane ◽  
Ultrafine Fiber ◽  
A Charge

Formulation, Design and Development of Niosome Based Topical Gel for Skin Cancer

2017 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Skin Cancer ◽  
Drug Release ◽  
Hemorrhagic Cystitis ◽  
The Body ◽  
Cancer Drug ◽  
Inversion Method ◽  
Body Parts ◽  
Basal Cells ◽  
Formulation Design ◽  
Topical Gel

Melanoma is the most dangerous type of skin cancer in which mostly damaged unpaired DNA starts mutating abnormally and staged an unprecedented proliferation of epithelial skin to form a malignant tumor. In epidemics of skin, pigment-forming melanocytes of basal cells start depleting and form uneven black or brown moles. Melanoma can further spread all over the body parts and could become hard to detect. In USA Melanoma kills an estimated 10,130 people annually. This challenge can be succumbed by using the certain anti-cancer drug. In this study design, cyclophosphamide were used as a model drug. But it has own limitation like mild to moderate use may cause severe cytopenia, hemorrhagic cystitis, neutropenia, alopecia and GI disturbance. This is a promising challenge, which is caused due to the increasing in plasma drug concentration above therapeutic level and due to no rate limiting steps involved in formulation design. In this study, we tried to modify drug release up to threefold and extended the release of drug by preparing and designing niosome based topical gel. In the presence of Dichloromethane, Span60 and cholesterol, the initial niosomes were prepared using vacuum evaporator. The optimum percentage drug entrapment efficacy, zeta potential, particle size was found to be 72.16%, 6.19mV, 1.67µm.Prepared niosomes were further characterized using TEM analyzer. The optimum batch of niosomes was selected and incorporated into topical gel preparation. Cold inversion method and Poloxamer -188 and HPMC as core polymers, were used to prepare cyclophosphamide niosome based topical gel. The formula was designed using Design expert 7.0.0 software and Box-Behnken Design model was selected. Almost all the evaluation parameters were studied and reported. The MTT shows good % cell growth inhibition by prepared niosome based gel against of A375 cell line. The drug release was extended up to 20th hours. Further as per ICH Q1A (R2), guideline 6 month stability studies were performed. The results were satisfactory and indicating a good formulation approach design was achieved for Melanoma treatment.

Effects of release modifier on Carvedilol release from Kollidon SR based matrix

2012 ◽  
Vol 1 (8) ◽  
pp. 186 ◽  
Author(s):  
Urmi Das ◽  
Mohammad Salim Hossain
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Microcrystalline Cellulose ◽  
Matrix Tablets ◽  
Dissolution Time ◽  
Release Mechanism ◽  
Matrix Tablet ◽  
Weight Variation ◽  
The Matrix ◽  
Tablet Formulations

<p>Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.</p><p>DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a></p> <p>International Current Pharmaceutical Journal 2012, 1(8): 186-192</p>

Digital Curation, AustLit, and Australian Children's Literature

2019 ◽  
Vol 12 (1) ◽  
pp. 1-17
Author(s):  
Amy Cross ◽  
Cherie Allan ◽  
Kerry Kilner
Keyword(s):  
Children's Literature ◽  
Cultural History ◽  
Literary History ◽  
Children’S Literature ◽  
Distant Reading ◽  
Critical Spaces ◽  
Reading Methods ◽  
Digital Curation ◽  
Definition Of ◽  
Significant Attention

This paper examines the effects of curatorial processes used to develop children's literature digital research projects in the bibliographic database AustLit. Through AustLit's emphasis on contextualising individual works within cultural, biographical, and critical spaces, Australia's literary history is comprehensively represented in a unique digital humanities space. Within AustLit is BlackWords, a project dedicated to recording Australia's Aboriginal and Torres Strait Islander storytelling, publishing, and literary cultural history, including children's and young adult texts. Children's literature has received significant attention in AustLit (and BlackWords) over the last decade through three projects that are documented in this paper. The curation of this data highlights the challenges in presenting ‘national’ literatures in countries where minority voices were (and perhaps continue to be) repressed and unseen. This paper employs a ‘resourceful reading’ approach – both close and distant reading methods – to trace the complex and ever-evolving definition of ‘Australian children's literature’.

The Improvement of Paclitaxel Cytotoxicity using Nanocellulose based Nature Resources

2019 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
R Nahrowi ◽  
A Setiawan ◽  
Noviany Noviany ◽  
I Sukmana ◽  
S D Yuwono
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Natural Resources ◽  
Cell Viability ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Target Cell ◽  
Mitotic Cycle ◽  
Potential Sources ◽  
Local Accumulation

Paclitaxel is one of the cancer drugs that often used. These drug kills cancer cells byinhibiting mitotic cycle. The efficiency of paclitaxel is increased by the use ofnanomaterials as a carrier of paclitaxel. Nanomaterials can enhance encapsulationefficiency, improve the drug release to the target cell following nanomaterialdegradation, and improve local accumulation of drug in the cell through endocytosisreceptor. Nanomaterial that often used forencapsulation of paclitaxel is a polymerderived from natural resources such as cellulose. The advantages of cellulose as acarrier of paclitaxel are nontoxic, biodegradable, and very abundant from varioussources. One of the potential sources of cellulose for drug delivery system is cassavabaggase.Keywords: Paclitaxel, encapsulation, cell viability, nanocellulose

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