Dually crosslinked injectable hydrogels of poly(ethylene glycol) and poly[(2-dimethylamino)ethyl methacrylate]-b-poly(N-isopropyl acrylamide) as a wound healing promoter

2017 ◽  
Vol 5 (25) ◽  
pp. 4955-4965 ◽  
Author(s):  
Arvind K. Singh Chandel ◽  
Deepika Kannan ◽  
Bhingaradiya Nutan ◽  
Shailja Singh ◽  
Suresh K. Jewrajka
Keyword(s):  
Molecular Weight ◽  
Wound Healing ◽  
Tissue Regeneration ◽  
Poly Ethylene Glycol ◽  
Small Molecular Weight ◽  
Injectable Hydrogels ◽  
Soft Tissue Regeneration ◽  
Isopropyl Acrylamide ◽  
Poly Ethylene ◽  
By Products

PEG-based dually crosslinked injectable hydrogels have been developed through extremely simple chemistry which avoids use of small molecular weight crosslinker, formation of by-products and involved low heat change. The hydrogels are useful for wound healing and soft tissue regeneration.

scholarly journals Development of Nontoxic Biodegradable Polyurethanes Based on Polyhydroxyalkanoate and L-lysine Diisocyanate with Improved Mechanical Properties as New Elastomers Scaffolds

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1927 ◽  
Author(s):  
Cai Wang ◽  
Jiapeng Xie ◽  
Xuan Xiao ◽  
Shaojun Chen ◽  
Yiping Wang
Keyword(s):  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Poly Ethylene Glycol ◽  
In Vitro Degradation ◽  
Elongation At Break ◽  
Molar Ratios ◽  
Soft Tissue Regeneration ◽  
Biodegradable Polyurethane ◽  
Poly Ethylene

A nontoxic and biodegradable polyurethane was prepared, characterized, and evaluated for biomedical applications. Stretchable, biodegradable, and biocompatible polyurethanes (LPH) based on L-lysine diisocyanate (LDI) with poly(ethylene glycol) (PEG) and polyhydroxyalkanoates(PHA) of different molar ratios were synthesized. The chemical and physical characteristics of the LPH films are tunable, enabling the design of mechanically performance, hydrophilic, and biodegradable behavior. The LPH films have a Young’s modulus, tensile strength, and elongation at break in the range of 3.07–25.61 MPa, 1.01–9.49 MPa, and 102–998%, respectively. The LPH films demonstrate different responses to a change of temperature from 4 to 37 °C, with the swelling ratio for the same sample at equilibrium varying from 184% to 151%. In vitro degradation tests show the same LPH film has completely different degradation morphologies in pH of 3, 7.4, and 11 phosphate buffered solution (PBS). In vitro cell tests show feasibility that some of the LPH films are suitable for culturing rat bone marrow stem cells (rBMSCs), for future soft-tissue regeneration. The results demonstrate the feasibility of the LPH scaffolds for many biomedical applications.

scholarly journals Isothermal Crystallization Kinetics of Poly(ethylene oxide)/Poly(ethylene glycol)-g-silica Nanocomposites

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 648
Author(s):  
Xiangning Wen ◽  
Yunlan Su ◽  
Shaofan Li ◽  
Weilong Ju ◽  
Dujin Wang
Keyword(s):  
Molecular Weight ◽  
Ethylene Oxide ◽  
Crystallization Kinetics ◽  
Isothermal Crystallization ◽  
Crystallization Rate ◽  
Poly Ethylene Glycol ◽  
Isothermal Crystallization Kinetics ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Kinetics Of

In this work, the crystallization kinetics of poly(ethylene oxide) (PEO) matrix included with poly(ethylene glycol) (PEG) grafted silica (PEG-g-SiO2) nanoparticles and bare SiO2 were systematically investigated by differential scanning calorimetry (DSC) and polarized light optical microscopy (PLOM) method. PEG-g-SiO2 can significantly increase the crystallinity and crystallization temperature of PEO matrix under the non-isothermal crystallization process. Pronounced effects of PEG-g-SiO2 on the crystalline morphology and crystallization rate of PEO were further characterized by employing spherulitic morphological observation and isothermal crystallization kinetics analysis. In contrast to the bare SiO2, PEG-g-SiO2 can be well dispersed in PEO matrix at low P/N (P: Molecular weight of matrix chains, N: Molecular weight of grafted chains), which is a key factor to enhance the primary nucleation rate. In particular, we found that the addition of PEG-g-SiO2 slows the spherulitic growth fronts compared to the neat PEO. It is speculated that the interfacial structure of the grafted PEG plays a key role in the formation of nuclei sites, thus ultimately determines the crystallization behavior of PEO PNCs and enhances the overall crystallization rate of the PEO nanocomposites.

Hydrolytically and Reductively Degradable High-Molecular-Weight Poly(ethylene glycol)s

2007 ◽  
Vol 208 (24) ◽  
pp. 2642-2653 ◽  
Author(s):  
Alena Braunová ◽  
Michal Pechar ◽  
Richard Laga ◽  
Karel Ulbrich
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
High Molecular Weight ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
High Molecular Weight Poly

Mapping the dominant wound healing and soft tissue regeneration QTL in MRL × CAST

2005 ◽  
Vol 16 (12) ◽  
pp. 918-924 ◽  
Author(s):  
Hongrun Yu ◽  
Subburaman Mohan ◽  
Godfred L. Masinde ◽  
David J. Baylink
Keyword(s):  
Wound Healing ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration

Microporous Bio-Membrane Materials Based on High Molecular Weight Polylactide and Low Molecular Weight Poly(ethylene glycol)

2012 ◽  
Vol 567 ◽  
pp. 123-126
Author(s):  
Teng Fei Shen ◽  
Man Geng Lu ◽  
Li Yan Liang
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
High Weight ◽  
Low Molecular Weight ◽  
Poly Ethylene Glycol ◽  
Degradation Rates ◽  
Degradation Behaviors ◽  
The Mean ◽  
Poly Ethylene ◽  
Lower Glass Transition Temperature

In this work, microporous membrane biomaterials based on high weight molecular polylactide (PLA) and low molecular weight poly(ethylene glycol) (PEG) using rapid solvent evaporation method were prepared and investigated. The effect of PEG segments added on the thermal and degradation behaviors was studied. According to the results, produced PLA/PEG biomaterial has lower glass transition temperature (Tg)in comparison with neat PLA. It was also found that the degradation rates of the PLA/PEG biomaterials were significantly increased with adding of PEG, which explained by increasing hydrophilic groups. For better porous fixation, CL-blocked polyisocyanate (CL-bp), which was synthesized from reaction of isophorone diisocyanate (IPDI) with dimethylol propionic acid (DMPA) and Trimethylolpropane (TMP) followed by addition of caprolactam (CL), were introduced. The microporous forms were observed by the scanning electron microscope (SEM), which showed the mean diameters of prepared PLA/PEG microporous were around 10μm.

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