A highly efficient, low-toxic, wide-spectrum antibacterial coating designed for 3D printed implants with tailorable release properties

2017 ◽  
Vol 5 (22) ◽  
pp. 4128-4136 ◽  
Author(s):  
Chaowen Xue ◽  
Xiangwei Song ◽  
Mingzhuo Liu ◽  
Fanrong Ai ◽  
Miaoxing Liu ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Wide Spectrum ◽  
Antibacterial Coating ◽  
Highly Efficient ◽  
Antibacterial Coatings ◽  
3D Printed ◽  
Low Toxic

A broad spectrum antibacterial coatings with tailorable release properties were developed for 3D printed implants.

α-C–H difluoroalkylation of alkyl sulfoxides via intermolecular Pummerer reaction

2021 ◽  
Author(s):  
Xin Huang ◽  
Weizhao Zhao ◽  
Yuchen Liang ◽  
Minghui Wang ◽  
Yaling Zhan ◽  
...  
Keyword(s):  
Wide Spectrum ◽  
Pummerer Reaction ◽  
Silyl Ethers ◽  
Highly Efficient

A simple and practical intermolecular Pummerer reaction using difluoroenol silyl ethers as nucleophiles is described. The protocol allows for highly efficient α-difluoroalkylation of a wide spectrum of alkyl sulfoxides.

Highly Efficient Dual-Fiber Optical Trapping with 3D Printed Diffractive Fresnel Lenses

ACS Photonics ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 88-97 ◽  
Author(s):  
Asa Asadollahbaik ◽  
Simon Thiele ◽  
Ksenia Weber ◽  
Aashutosh Kumar ◽  
Johannes Drozella ◽  
...  
Keyword(s):  
Optical Trapping ◽  
Highly Efficient ◽  
Fiber Optical ◽  
Fresnel Lenses ◽  
3D Printed

Ag-Conjugated graphene quantum dots with blue light-enhanced singlet oxygen generation for ternary-mode highly-efficient antimicrobial therapy

2020 ◽  
Vol 8 (7) ◽  
pp. 1371-1382 ◽  
Author(s):  
Yunjian Yu ◽  
Lin Mei ◽  
Yanmei Shi ◽  
Xinge Zhang ◽  
Kesong Cheng ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Singlet Oxygen ◽  
Blue Light ◽  
Silver Nanoparticle ◽  
Broad Spectrum ◽  
Antimicrobial Therapy ◽  
Graphene Quantum Dots ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Highly Efficient

A broad-spectrum antibacterial system was produced in which silver nanoparticle-conjugated graphene quantum dots were utilised as a blue light-enhanced nanotherapeutic for efficient ternary-mode antimicrobial therapy.

scholarly journals Correction to “3D-Printed Anti-Fouling Cellulose Mesh for Highly Efficient Oil/Water Separation Applications”

2019 ◽  
Vol 11 (38) ◽  
pp. 35510-35510
Author(s):  
J. Justin Koh ◽  
Gwendolyn J.H. Lim ◽  
Xin Zhou ◽  
Xiwen Zhang ◽  
Jun Ding ◽  
...  
Keyword(s):  
Water Separation ◽  
Highly Efficient ◽  
Oil Water Separation ◽  
3D Printed ◽  
Oil Water

3D-Printed Anti-Fouling Cellulose Mesh for Highly Efficient Oil/Water Separation Applications

2019 ◽  
Vol 11 (14) ◽  
pp. 13787-13795 ◽  
Author(s):  
J. Justin Koh ◽  
Gwendolyn J.H. Lim ◽  
Xin Zhou ◽  
Xiwen Zhang ◽  
Jun Ding ◽  
...  
Keyword(s):  
Water Separation ◽  
Highly Efficient ◽  
Oil Water Separation ◽  
3D Printed ◽  
Oil Water

scholarly journals 3D printed zirconia ceramic hip joint with precise structure and broad-spectrum antibacterial properties

2019 ◽  
Vol Volume 14 ◽  
pp. 5977-5987 ◽  
Author(s):  
Yanglong Zhu ◽  
Kuan Liu ◽  
Jianjian Deng ◽  
Jing Ye ◽  
Fanrong Ai ◽  
...  
Keyword(s):  
Hip Joint ◽  
Broad Spectrum ◽  
Antibacterial Properties ◽  
Zirconia Ceramic ◽  
3D Printed

Living the heart in three dimensions: applications of 3D printing in CHD

2019 ◽  
Vol 29 (06) ◽  
pp. 733-743 ◽  
Author(s):  
Mari Nieves Velasco Forte ◽  
Tarique Hussain ◽  
Arno Roest ◽  
Gorka Gomez ◽  
Monique Jongbloed ◽  
...  
Keyword(s):  
3D Printing ◽  
Heart Surgery ◽  
Wide Spectrum ◽  
Three Dimensional ◽  
Structural Heart Disease ◽  
Medical Personnel ◽  
Three Dimensions ◽  
Patient Specific ◽  
3D Printed

AbstractAdvances in biomedical engineering have led to three-dimensional (3D)-printed models being used for a broad range of different applications. Teaching medical personnel, communicating with patients and relatives, planning complex heart surgery, or designing new techniques for repair of CHD via cardiac catheterisation are now options available using patient-specific 3D-printed models. The management of CHD can be challenging owing to the wide spectrum of morphological conditions and the differences between patients. Direct visualisation and manipulation of the patients’ individual anatomy has opened new horizons in personalised treatment, providing the possibility of performing the whole procedure in vitro beforehand, thus anticipating complications and possible outcomes. In this review, we discuss the workflow to implement 3D printing in clinical practice, the imaging modalities used for anatomical segmentation, the applications of this emerging technique in patients with structural heart disease, and its limitations and future directions.

Choice of an Effective Non-Viral System for the Delivery of siRNA to Multipotent Mesenchymal Stromal Cells

2020 ◽  
Vol 36 (4) ◽  
pp. 74-79
Author(s):  
Т.В. Bukharova ◽  
A.A. Buianova ◽  
K.S. Davygora ◽  
D.V. Goldshtein
Keyword(s):  
Nucleic Acids ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Medical Genetics ◽  
The Body ◽  
Research Centre ◽  
Cationic Polymers ◽  
Highly Efficient ◽  
Low Toxic

Multipotent mesenchymal stromal cells (MSCs) can be used as a model for the development of gene and cell technologies and as a means of delivering nucleic acids to the body, including as part of tissue-engineering constructs. Small interfering RNA (siRNA) molecules acting by the RNA interference mechanism are a high-precision tool for genetic silencing of target mRNA transcripts. The search for low toxic and highly efficient transfection agents for delivery of siRNA or other nucleic acids to MSCs is an urgent task for the development of therapy based on these molecules. A comparative evaluation of five transfection agents showed that compounds based on cationic polymers were more efficient in delivering siRNA molecules than liposomes, while the cytotoxicity of all tested reagents was independent of their chemical structure. For two of the three transfection agents selected according to their efficiency and belonging to different classes, TurboFect and Lipofectamine® 3000, a moderate effect on cell viability was revealed. The results obtained allow us to recommend TurboFect and Lipofectamine® 3000 as highly efficient and relatively low-toxic agents for transfection of MSCs cultures. multipotent mesenchymal stromal cells, siRNA, transfection, lipofection, cationic lipids, cationic polymers, polyethyleneimine. The authors are grateful to staff of functional genomics laboratory of Research Centre for Medical Genetics Skoblova M.Yu. and Krivosheeva I.A., for technical and methodological assistance. The work was financially supported by the Ministry of Science and Higher Education of the Russian Federation within the state assignment for Research Centre for Medical Genetics.

scholarly journals Antibacterial coating of implants: are we missing something?

2019 ◽  
Vol 8 (5) ◽  
pp. 199-206 ◽  
Author(s):  
C. L. Romanò ◽  
H. Tsuchiya ◽  
I. Morelli ◽  
A. G. Battaglia ◽  
L. Drago
Keyword(s):  
Large Scale ◽  
Hospital Costs ◽  
Economic Assessment ◽  
Regulatory Pathways ◽  
Surgical Infection ◽  
Antibacterial Coating ◽  
Antibacterial Coatings ◽  
Preclinical And Clinical Studies ◽  
The Cost ◽  
The Impact

Implant-related infection is one of the leading reasons for failure in orthopaedics and trauma, and results in high social and economic costs. Various antibacterial coating technologies have proven to be safe and effective both in preclinical and clinical studies, with post-surgical implant-related infections reduced by 90% in some cases, depending on the type of coating and experimental setup used. Economic assessment may enable the cost-to-benefit profile of any given antibacterial coating to be defined, based on the expected infection rate with and without the coating, the cost of the infection management, and the cost of the coating. After reviewing the latest evidence on the available antibacterial coatings, we quantified the impact caused by delaying their large-scale application. Considering only joint arthroplasties, our calculations indicated that for an antibacterial coating, with a final user’s cost price of €600 and able to reduce post-surgical infection by 80%, each year of delay to its large-scale application would cause an estimated 35 200 new cases of post-surgical infection in Europe, equating to additional hospital costs of approximately €440 million per year. An adequate reimbursement policy for antibacterial coatings may benefit patients, healthcare systems, and related research, as could faster and more affordable regulatory pathways for the technologies still in the pipeline. This could significantly reduce the social and economic burden of implant-related infections in orthopaedics and trauma.Cite this article: C. L. Romanò, H. Tsuchiya, I. Morelli, A. G. Battaglia, L. Drago. Antibacterial coating of implants: are we missing something? Bone Joint Res 2019;8:199–206. DOI: 10.1302/2046-3758.85.BJR-2018-0316.

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