Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

2017 ◽  
Vol 5 (17) ◽  
pp. 3217-3229 ◽  
Author(s):  
C. Rizzo ◽  
R. Arrigo ◽  
F. D'Anna ◽  
F. Di Blasi ◽  
N. T. Dintcheva ◽  
...  
Keyword(s):  
Sustained Release ◽  
Self Assembly ◽  
Halloysite Nanotubes ◽  
Supramolecular Gel ◽  
Supramolecular Gels

Novel supramolecular gel hybrids were prepared by self-assembly of Fmoc-l-phenylalanine in the presence of functionalized halloysite nanotubes and employed as carriers for the delivery of camptothecin molecules.

Synthesis of supramolecular gels based on electron-transfer reactions between clay nanotubes and styrene

2019 ◽  
Vol 55 (72) ◽  
pp. 10756-10759 ◽  
Author(s):  
Jingqi Zheng ◽  
Xianfeng Ou ◽  
Fan Wu ◽  
Mingxian Liu
Keyword(s):  
Electron Transfer ◽  
Halloysite Nanotubes ◽  
Ultrasound Treatment ◽  
Transfer Reactions ◽  
Electron Transfer Reactions ◽  
Supramolecular Gel ◽  
Supramolecular Gels ◽  
Clay Nanotubes

A novel supramolecular gel is synthesized using styrene and halloysite nanotubes under ultrasound treatment, in which the nanotubes act as gelators for the styrene gel.

scholarly journals Development of In Situ Self-Assembly Nanoparticles to Encapsulate Lopinavir and Ritonavir for Long-Acting Subcutaneous Injection

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 904
Author(s):  
Irin Tanaudommongkon ◽  
Asama Tanaudommongkon ◽  
Xiaowei Dong
Keyword(s):  
Sustained Release ◽  
Trough Concentration ◽  
Self Assembly ◽  
Subcutaneous Injection ◽  
Drug Loading ◽  
Entrapment Efficiency ◽  
Long Acting

Most antiretroviral medications for human immunodeficiency virus treatment and prevention require high levels of patient adherence, such that medications need to be administered daily without missing doses. Here, a long-acting subcutaneous injection of lopinavir (LPV) in combination with ritonavir (RTV) using in situ self-assembly nanoparticles (ISNPs) was developed to potentially overcome adherence barriers. The ISNP approach can improve the pharmacokinetic profiles of the drugs. The ISNPs were characterized in terms of particle size, drug entrapment efficiency, drug loading, in vitro release study, and in vivo pharmacokinetic study. LPV/RTV ISNPs were 167.8 nm in size, with a polydispersity index of less than 0.35. The entrapment efficiency was over 98% for both LPV and RTV, with drug loadings of 25% LPV and 6.3% RTV. A slow release rate of LPV was observed at about 20% on day 5, followed by a sustained release beyond 14 days. RTV released faster than LPV in the first 5 days and slower than LPV thereafter. LPV trough concentration remained above 160 ng/mL and RTV trough concentration was above 50 ng/mL after 6 days with one subcutaneous injection. Overall, the ISNP-based LPV/RTV injection showed sustained release profiles in both in vitro and in vivo studies.

scholarly journals Self-assembly of the monohydroxy triterpenoid lupeol yielding nano-fibers, sheets and gel: environmental and drug delivery applications

RSC Advances ◽  
2021 ◽  
Vol 11 (53) ◽  
pp. 33500-33510
Author(s):  
Saikat Kumar Panja ◽  
Soumen Patra ◽  
Braja Gopal Bag
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Organic Liquids ◽  
Supramolecular Gels ◽  
Drug Delivery Applications

The monohydroxy triterpenoid lupeol forms gels in organic and aqueous organic liquids via self-assembly. The resulting supramolecular gels could be utilized for pollutant capture, drug entrapment and release applications.

Modification of halloysite nanotubes with supramolecular self-assembly aggregates for reducing smoke release and fire hazard of polypropylene

2019 ◽  
Vol 177 ◽  
pp. 107371 ◽  
Author(s):  
Sheng Shang ◽  
Xiao Ma ◽  
Bihe Yuan ◽  
Gongqing Chen ◽  
Yaru Sun ◽  
...  
Keyword(s):  
Self Assembly ◽  
Fire Hazard ◽  
Halloysite Nanotubes

Functional supramolecular gels based on pillar[n]arene macrocycles

Nanoscale ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 2180-2200 ◽  
Author(s):  
Yong-Fu Li ◽  
Zheng Li ◽  
Qi Lin ◽  
Ying-Wei Yang
Keyword(s):  
Supramolecular Gel ◽  
Supramolecular Gels ◽  
Recent Developments

Recent developments of functional supramolecular gel materials constructed from pillararenes have been overviewed.

Photoresponsive supramolecular gels based on amphiphiles with azobenzene and maltose or polyethyleneglycol polar head

2015 ◽  
Vol 39 (5) ◽  
pp. 4009-4019 ◽  
Author(s):  
María José Clemente ◽  
Rosa María Tejedor ◽  
Pilar Romero ◽  
Juliette Fitremann ◽  
Luis Oriol
Keyword(s):  
External Stimulus ◽  
Gel Structure ◽  
Supramolecular Gel ◽  
Polar Head ◽  
Supramolecular Gels ◽  
Reversible Gel

Photoresponsive supramolecular gelators have been synthesized using PEG or d-maltose as polar head. Incorporation of azobenzene photoresponsive moieties allows controlling the supramolecular gel structure, including a reversible gel–sol transition using light as external stimulus.

Terphen[ n ]arenes and Quaterphen[ n ]arenes ( n =3–6): One‐Pot Synthesis, Self‐Assembly into Supramolecular Gels, and Iodine Capture

2019 ◽  
Vol 131 (12) ◽  
pp. 3925-3929 ◽  
Author(s):  
Bin Li ◽  
Bin Wang ◽  
Xiayang Huang ◽  
Lu Dai ◽  
Lei Cui ◽  
...  
Keyword(s):  
Self Assembly ◽  
One Pot ◽  
One Pot Synthesis ◽  
Supramolecular Gels

scholarly journals Annealing multicomponent supramolecular gels

Nanoscale ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 3275-3280 ◽  
Author(s):  
Ana M. Fuentes-Caparrós ◽  
Francisco de Paula Gómez-Franco ◽  
Bart Dietrich ◽  
Claire Wilson ◽  
Christopher Brasnett ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Supramolecular Gel ◽  
Two Component ◽  
Supramolecular Gels

Annealing in a two-component supramolecular gel leads to a self-sorted network, which has significantly different mechanical properties to the as-prepared gels.

Sign in / Sign up

Export Citation Format

Share Document