Multiple stimuli-responsive selenium-functionalized biodegradable starch-based hydrogels

Soft Matter ◽  
2018 ◽  
Vol 14 (6) ◽  
pp. 921-926 ◽  
Author(s):  
Tongbing Sun ◽  
Caizhen Zhu ◽  
Jian Xu
Keyword(s):  
Free Radical ◽  
Drug Release ◽  
Biomedical Applications ◽  
Radical Copolymerization ◽  
Enzyme Hydrolysis ◽  
Stimuli Responsive ◽  
Free Radical Copolymerization ◽  
Redox Responsive

Biodegradable diselenide cross-linked starch-based hydrogels, composed of starch chain backbones with an enzyme hydrolysis property and selenium-containing cross-linkers with a redox responsive cleavage property, were synthesizedviafree radical copolymerization and used as stimuli-responsive drug release materials for biomedical applications.

scholarly journals Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1108
Author(s):  
Manuela Curcio ◽  
Alessandro Paolì ◽  
Giuseppe Cirillo ◽  
Sebastiano Di Pietro ◽  
Martina Forestiero ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Metastatic Cancer ◽  
Stimuli Responsive ◽  
Cancer Disease ◽  
New Class ◽  
Self Assembling ◽  
Redox Responsive ◽  
Potential Applicability ◽  
Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

High-pressure free-radical copolymerization of ethene and 2-ethylhexyl acrylate

1996 ◽  
Vol 197 (12) ◽  
pp. 4119-4134 ◽  
Author(s):  
Michael Buback ◽  
Thomas Dröge ◽  
Alex Van Herk ◽  
Frank-Olaf Mähling
Keyword(s):  
High Pressure ◽  
Free Radical ◽  
Radical Copolymerization ◽  
Free Radical Copolymerization

Free Radical Copolymerization of Ethylene with Vinyl Acetate under Mild Conditions

2017 ◽  
Vol 50 (9) ◽  
pp. 3516-3523 ◽  
Author(s):  
A. Zarrouki ◽  
E. Espinosa ◽  
C. Boisson ◽  
V. Monteil
Keyword(s):  
Free Radical ◽  
Vinyl Acetate ◽  
Radical Copolymerization ◽  
Free Radical Copolymerization ◽  
Mild Conditions

Synthesis and characterization of hyperbranched associative polyacrylamide

RSC Advances ◽  
2016 ◽  
Vol 6 (45) ◽  
pp. 39522-39529 ◽  
Author(s):  
Wanfen Pu ◽  
Daijun Du ◽  
Rui Liu ◽  
Jiongyi Gu ◽  
Kewei Li ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Copolymerization ◽  
Synthesis And Characterization ◽  
Functional Monomer ◽  
Free Radical Copolymerization ◽  
Ultrafine Silica ◽  
Hyperbranched Polyamide

HDPAM was synthesized by water free-radical copolymerization based on functional hyperbranched polyamide-modified ultrafine silica as functional monomer.

Strain hardening and highly resilient hydrogels crosslinked by chain-extended reactive pseudo-polyrotaxane

RSC Advances ◽  
2014 ◽  
Vol 4 (100) ◽  
pp. 56791-56797 ◽  
Author(s):  
Yulin Cui ◽  
Mei Tan ◽  
Aidi Zhu ◽  
Mingyu Guo
Keyword(s):  
Free Radical ◽  
Strain Hardening ◽  
Radical Copolymerization ◽  
Free Radical Copolymerization

Hydrogels with obvious strain hardening and high resilience properties in both stretching and compressing processes are constructed by simple free-radical copolymerization of acrylamide and reactive pseudo-polyrotaxane.

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