Chiral amplification of disodium cromoglycate chromonics induced by a codeine derivative

Soft Matter ◽  
2017 ◽  
Vol 13 (38) ◽  
pp. 6810-6815 ◽  
Author(s):  
F. Berride ◽  
E. Troche-Pesqueira ◽  
G. Feio ◽  
E. J. Cabrita ◽  
T. Sierra ◽  
...  
Keyword(s):  
Liquid Crystals ◽  
Disodium Cromoglycate ◽  
Chiral Amplification ◽  
Discotic Mesogens ◽  
Lyotropic Phases

Chromonic liquid crystals (CLC) are lyotropic phases formed by discotic mesogens in water.

scholarly journals Structures and topological defects in pressure-driven lyotropic chromonic liquid crystals

2021 ◽  
Vol 118 (35) ◽  
pp. e2108361118
Author(s):  
Qing Zhang ◽  
Rui Zhang ◽  
Baoliang Ge ◽  
Zahid Yaqoob ◽  
Peter T. C. So ◽  
...  
Keyword(s):  
Liquid Crystals ◽  
Microfluidic Channel ◽  
Topological Defects ◽  
Interference Microscopy ◽  
Scaling Analysis ◽  
Imaging Method ◽  
Single Shot ◽  
Disodium Cromoglycate ◽  
Flowing Liquid ◽  
Pressure Driven

Lyotropic chromonic liquid crystals are water-based materials composed of self-assembled cylindrical aggregates. Their behavior under flow is poorly understood, and quantitatively resolving the optical retardance of the flowing liquid crystal has so far been limited by the imaging speed of current polarization-resolved imaging techniques. Here, we employ a single-shot quantitative polarization imaging method, termed polarized shearing interference microscopy, to quantify the spatial distribution and the dynamics of the structures emerging in nematic disodium cromoglycate solutions in a microfluidic channel. We show that pure-twist disclination loops nucleate in the bulk flow over a range of shear rates. These loops are elongated in the flow direction and exhibit a constant aspect ratio that is governed by the nonnegligible splay-bend anisotropy at the loop boundary. The size of the loops is set by the balance between nucleation forces and annihilation forces acting on the disclination. The fluctuations of the pure-twist disclination loops reflect the tumbling character of nematic disodium cromoglycate. Our study, including experiment, simulation, and scaling analysis, provides a comprehensive understanding of the structure and dynamics of pressure-driven lyotropic chromonic liquid crystals and might open new routes for using these materials to control assembly and flow of biological systems or particles in microfluidic devices.

scholarly journals Label-Free Detection and Spectrometrically Quantitative Analysis of the Cancer Biomarker CA125 Based on Lyotropic Chromonic Liquid Crystal

Biosensors ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 271
Author(s):  
Hassanein Shaban ◽  
Mon-Juan Lee ◽  
Wei Lee
Keyword(s):  
Liquid Crystals ◽  
Limit Of Detection ◽  
Optical Signal ◽  
Cancer Biomarker ◽  
Disodium Cromoglycate ◽  
Label Free ◽  
Light Spectrum ◽  
Linear Calibration ◽  
Label Free Detection ◽  
Anchoring Strength

Compared with thermotropic liquid crystals (LCs), the biosensing potential of lyotropic chromonic liquid crystals (LCLCs), which are more biocompatible because of their hydrophilic nature, has scarcely been investigated. In this study, the nematic phase, a mesophase shared by both thermotropic LCs and LCLCs, of disodium cromoglycate (DSCG) was employed as the sensing mesogen in the LCLC-based biosensor. The biosensing platform was constructed so that the LCLC was homogeneously aligned by the planar anchoring strength of polyimide, but was disrupted in the presence of proteins such as bovine serum albumin (BSA) or the cancer biomarker CA125 captured by the anti-CA125 antibody, with the level of disturbance (and the optical signal thus produced) predominated by the amount of the analyte. The concentration- and wavelength-dependent optical response was analyzed by transmission spectrometry in the visible light spectrum with parallel or crossed polarizers. The concentration of CA125 can be quantified with spectrometrically derived parameters in a linear calibration curve. The limit of detection for both BSA and CA125 of the LCLC-based biosensor was superior or comparable to that of thermotropic LC-based biosensing techniques. Our results provide, to the best of our knowledge, the first evidence that LCLCs can be applied in spectrometrically quantitative biosensing.

Chiral lyotropic chromonic liquid crystals composed of disodium cromoglycate doped with water-soluble chiral additives

Soft Matter ◽  
2018 ◽  
Vol 14 (9) ◽  
pp. 1511-1516 ◽  
Author(s):  
Tatsuya Shirai ◽  
Min Shuai ◽  
Keita Nakamura ◽  
Akihiro Yamaguchi ◽  
Yumiko Naka ◽  
...  
Keyword(s):  
Liquid Crystals ◽  
Water Soluble ◽  
Disodium Cromoglycate ◽  
Cholesteric Liquid Crystals

We investigated the pitches of cholesteric liquid crystals prepared by mixing disodium cromoglycate (DSCG) in water with 5 different water-soluble chiral additives.

The Structure and Development of Microbodies in the Fat Body and other Tissues of an Insect (Calpodes Ethlius)

1970 ◽  
Vol 28 ◽  
pp. 148-149
Author(s):  
M. Locke ◽  
J. T. McMahon
Keyword(s):  
Electron Microscopy ◽  
Liquid Crystals ◽  
Fat Body ◽  
Competitive Inhibitor ◽  
Dense Core ◽  
Urate Oxidase ◽  
Blood Proteins ◽  
Free Base ◽  
The Core ◽  
The Matrix

The fat body of insects has always been compared functionally to the liver of vertebrates. Both synthesize and store glycogen and lipid and are concerned with the formation of blood proteins. The comparison becomes even more apt with the discovery of microbodies and the localization of urate oxidase and catalase in insect fat body.The microbodies are oval to spherical bodies about 1μ across with a depression and dense core on one side. The core is made of coiled tubules together with dense material close to the depressed membrane. The tubules may appear loose or densely packed but always intertwined like liquid crystals, never straight as in solid crystals (Fig. 1). When fat body is reacted with diaminobenzidine free base and H2O2 at pH 9.0 to determine the distribution of catalase, electron microscopy shows the enzyme in the matrix of the microbodies (Fig. 2). The reaction is abolished by 3-amino-1, 2, 4-triazole, a competitive inhibitor of catalase. The fat body is the only tissue which consistantly reacts positively for urate oxidase. The reaction product is sharply localized in granules of about the same size and distribution as the microbodies. The reaction is inhibited by 2, 6, 8-trichloropurine, a competitive inhibitor of urate oxidase.

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