scholarly journals Heterogeneity is key to hydrogel-based cartilage tissue regeneration

Soft Matter ◽  
2017 ◽  
Vol 13 (28) ◽  
pp. 4841-4855 ◽  
Author(s):  
Shankar Lalitha Sridhar ◽  
Margaret C. Schneider ◽  
Stanley Chu ◽  
Gaspard de Roucy ◽  
Stephanie J. Bryant ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Experimental Approach ◽  
Cartilage Tissue ◽  
Cell Distribution ◽  
Interstitial Growth

A combined computational-experimental approach showing the importance of heterogeneity in hydrogel properties and cell distribution, for the interstitial growth of cartilage.

Biomimetic composites and stem cells interaction for bone and cartilage tissue regeneration

2012 ◽  
Vol 22 (12) ◽  
pp. 5239 ◽  
Author(s):  
N. Naveena ◽  
J. Venugopal ◽  
R. Rajeswari ◽  
S. Sundarrajan ◽  
R. Sridhar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tissue Regeneration ◽  
Cartilage Tissue ◽  
And Cartilage

scholarly journals Tuning the Properties of PNIPAm-Based Hydrogel Scaffolds for Cartilage Tissue Engineering

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3154
Author(s):  
Md Mohosin Rana ◽  
Hector De la Hoz Siegler
Keyword(s):  
Tissue Engineering ◽  
Physical Properties ◽  
Tissue Regeneration ◽  
Structural Integrity ◽  
Cartilage Tissue ◽  
Design Parameters ◽  
Comprehensive Overview ◽  
Hydrogel Scaffolds ◽  
Design Variables

Poly(N-isopropylacrylamide) (PNIPAm) is a three-dimensional (3D) crosslinked polymer that can interact with human cells and play an important role in the development of tissue morphogenesis in both in vitro and in vivo conditions. PNIPAm-based scaffolds possess many desirable structural and physical properties required for tissue regeneration, but insufficient mechanical strength, biocompatibility, and biomimicry for tissue development remain obstacles for their application in tissue engineering. The structural integrity and physical properties of the hydrogels depend on the crosslinks formed between polymer chains during synthesis. A variety of design variables including crosslinker content, the combination of natural and synthetic polymers, and solvent type have been explored over the past decade to develop PNIPAm-based scaffolds with optimized properties suitable for tissue engineering applications. These design parameters have been implemented to provide hydrogel scaffolds with dynamic and spatially patterned cues that mimic the biological environment and guide the required cellular functions for cartilage tissue regeneration. The current advances on tuning the properties of PNIPAm-based scaffolds were searched for on Google Scholar, PubMed, and Web of Science. This review provides a comprehensive overview of the scaffolding properties of PNIPAm-based hydrogels and the effects of synthesis-solvent and crosslinking density on tuning these properties. Finally, the challenges and perspectives of considering these two design variables for developing PNIPAm-based scaffolds are outlined.

3D printed cell-laden collagen and hybrid scaffolds for in vivo articular cartilage tissue regeneration

2018 ◽  
Vol 66 ◽  
pp. 343-355 ◽  
Author(s):  
YoungWon Koo ◽  
Eun-Ji Choi ◽  
JaeYoon Lee ◽  
Han-Jun Kim ◽  
GeunHyung Kim ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Tissue Regeneration ◽  
Cartilage Tissue ◽  
3D Printed ◽  
Hybrid Scaffolds

scholarly journals Three-dimensional cartilage tissue regeneration system harnessing goblet-shaped microwells containing biocompatible hydrogel

2019 ◽  
Vol 12 (1) ◽  
pp. 015019 ◽  
Author(s):  
Nopphadol Udomluck ◽  
Sung-Hwan Kim ◽  
Hyunjoo Cho ◽  
Joong Yull Park ◽  
Hansoo Park
Keyword(s):  
Tissue Regeneration ◽  
Three Dimensional ◽  
Cartilage Tissue ◽  
Regeneration System

Cartilage-Derived Progenitor Cell-Laden Injectable Hydrogel—An Approach for Cartilage Tissue Regeneration

2020 ◽  
Vol 3 (8) ◽  
pp. 4756-4765
Author(s):  
Xiaolin Li ◽  
Sigen A ◽  
Qian Xu ◽  
Fatma Alshehri ◽  
Ming Zeng ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Progenitor Cell ◽  
Cartilage Tissue ◽  
Injectable Hydrogel
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