scholarly journals Dual-targeting biomimetic delivery for anti-glioma activityviaremodeling the tumor microenvironment and directing macrophage-mediated immunotherapy

2018 ◽  
Vol 9 (10) ◽  
pp. 2674-2689 ◽  
Author(s):  
Pengfei Zhao ◽  
Yonghui Wang ◽  
Xuejia Kang ◽  
Aihua Wu ◽  
Weimin Yin ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Treatment Strategy ◽  
Dual Targeting

A dual-targeting biomimetic codelivery and treatment strategy was developed for anti-glioma activity.

scholarly journals Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

Cell Reports ◽  
2021 ◽  
Vol 35 (2) ◽  
pp. 108994
Author(s):  
Anahid Ehteda ◽  
Sandy Simon ◽  
Laura Franshaw ◽  
Federico M. Giorgi ◽  
Jie Liu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Treatment Strategy ◽  
Dual Targeting

Tumor Microenvironment and Angiogenic Blood Vessels Dual-Targeting for Enhanced Anti-Glioma Therapy

2016 ◽  
Vol 8 (36) ◽  
pp. 23568-23579 ◽  
Author(s):  
Quanyin Hu ◽  
Ting Kang ◽  
Jingxian Feng ◽  
Qianqian Zhu ◽  
Tianze Jiang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Blood Vessels ◽  
Dual Targeting

scholarly journals Collective cancer invasion forms an integrin-dependent radioresistant niche

2019 ◽  
Vol 217 (1) ◽  
Author(s):  
Anna Haeger ◽  
Stephanie Alexander ◽  
Manon Vullings ◽  
Fabian M.P. Kaiser ◽  
Cornelia Veelken ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Dna Damage ◽  
Clinical Trials ◽  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Therapy Resistance ◽  
Mesenchymal Tumors ◽  
Dual Targeting ◽  
Extracellular Matrix Receptors

Cancer fatalities result from metastatic dissemination and therapy resistance, both processes that depend on signals from the tumor microenvironment. To identify how invasion and resistance programs cooperate, we used intravital microscopy of orthotopic sarcoma and melanoma xenografts. We demonstrate that these tumors invade collectively and that, specifically, cells within the invasion zone acquire increased resistance to radiotherapy, rapidly normalize DNA damage, and preferentially survive. Using a candidate-based approach to identify effectors of invasion-associated resistance, we targeted β1 and αVβ3/β5 integrins, essential extracellular matrix receptors in mesenchymal tumors, which mediate cancer progression and resistance. Combining radiotherapy with β1 or αV integrin monotargeting in invading tumors led to relapse and metastasis in 40–60% of the cohort, in line with recently failed clinical trials individually targeting integrins. However, when combined, anti-β1/αV integrin dual targeting achieved relapse-free radiosensitization and prevented metastatic escape. Collectively, invading cancer cells thus withstand radiotherapy and DNA damage by β1/αVβ3/β5 integrin cross-talk, but efficient radiosensitization can be achieved by multiple integrin targeting.

Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells

ACS Nano ◽  
2018 ◽  
Vol 12 (2) ◽  
pp. 1519-1536 ◽  
Author(s):  
Yaqi Lv ◽  
Chaoran Xu ◽  
Xiangmei Zhao ◽  
Chenshi Lin ◽  
Xin Yang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Dual Targeting

scholarly journals Dual targeting of RANKL/RANK pathway and HER-2 as a novel treatment strategy in HER-2 positive (+) breast carcinomas (BC)

2019 ◽  
Vol 30 ◽  
pp. iii21
Author(s):  
I. Zoi ◽  
E. Xingi ◽  
D. Thomaidou ◽  
A.G. Papavassiliou ◽  
M.V. Karamouzis
Keyword(s):  
Treatment Strategy ◽  
Breast Carcinomas ◽  
Dual Targeting ◽  
Novel Treatment ◽  
Her 2

Modulating the Tumor Microenvironment with RNA Interference as a Cancer Treatment Strategy

2014 ◽  
pp. 143-161 ◽  
Author(s):  
Karin Zins ◽  
Mouldy Sioud ◽  
Seyedhossein Aharinejad ◽  
Trevor Lucas ◽  
Dietmar Abraham
Keyword(s):  
Rna Interference ◽  
Tumor Microenvironment ◽  
Cancer Treatment ◽  
Treatment Strategy

Abstract 4541: Dual targeting of CDK4 and MEK as a combination treatment strategy for metastatic colorectal cancer

2014 ◽  
Author(s):  
Elizabeth Ziemke ◽  
Joseph Dosch ◽  
Amrith Shettigar ◽  
Shanshan Wan ◽  
Theodore Welling ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Combination Treatment ◽  
Treatment Strategy ◽  
Dual Targeting
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