scholarly journals A fluorenylidene-acridane that becomes dark in color upon grinding – ground state mechanochromism by conformational change

2018 ◽  
Vol 9 (2) ◽  
pp. 475-482 ◽  
Author(s):  
Tsuyoshi Suzuki ◽  
Hiroshi Okada ◽  
Takafumi Nakagawa ◽  
Kazuki Komatsu ◽  
Chikako Fujimoto ◽  
...  
Keyword(s):  
Conformational Change ◽  
Ground State ◽  
Color Change

We report mechanochromic color change controlled by conformational change (folded and twisted conformers) of fluorenylidene-acridanes (FAs).

scholarly journals Homologous ligands accommodated by discrete conformations of a buried cavity

2015 ◽  
Vol 112 (16) ◽  
pp. 5039-5044 ◽  
Author(s):  
Matthew Merski ◽  
Marcus Fischer ◽  
Trent E. Balius ◽  
Oliv Eidam ◽  
Brian K. Shoichet
Keyword(s):  
Conformational Change ◽  
Ground State ◽  
Main Chain ◽  
Ligand Design ◽  
Data Bank ◽  
T4 Lysozyme ◽  
Protein Conformations ◽  
Protein Conformational Change ◽  
Substantial Series ◽  
Alkyl Benzenes

Conformational change in protein–ligand complexes is widely modeled, but the protein accommodation expected on binding a congeneric series of ligands has received less attention. Given their use in medicinal chemistry, there are surprisingly few substantial series of congeneric ligand complexes in the Protein Data Bank (PDB). Here we determine the structures of eight alkyl benzenes, in single-methylene increases from benzene to n-hexylbenzene, bound to an enclosed cavity in T4 lysozyme. The volume of the apo cavity suffices to accommodate benzene but, even with toluene, larger cavity conformations become observable in the electron density, and over the series two other major conformations are observed. These involve discrete changes in main-chain conformation, expanding the site; few continuous changes in the site are observed. In most structures, two discrete protein conformations are observed simultaneously, and energetic considerations suggest that these conformations are low in energy relative to the ground state. An analysis of 121 lysozyme cavity structures in the PDB finds that these three conformations dominate the previously determined structures, largely modeled in a single conformation. An investigation of the few congeneric series in the PDB suggests that discrete changes are common adaptations to a series of growing ligands. The discrete, but relatively few, conformational states observed here, and their energetic accessibility, may have implications for anticipating protein conformational change in ligand design.

Renilla Bioluminescence: A Morphologic Approach to the Location of Photocytes

1974 ◽  
Vol 32 ◽  
pp. 208-209
Author(s):  
Ben O. Spurlock ◽  
Milton J. Cormier
Keyword(s):  
Excited State ◽  
Ground State ◽  
Molecular Basis ◽  
Light Emission ◽  
Chemical Basis ◽  
Electronic Excited State ◽  
Colonial Form ◽  
The Common ◽  
Eighteenth And Nineteenth Centuries ◽  
Catalyzed Oxidation

The phenomenon of bioluminescence has fascinated layman and scientist alike for many centuries. During the eighteenth and nineteenth centuries a number of observations were reported on the physiology of bioluminescence in Renilla, the common sea pansy. More recently biochemists have directed their attention to the molecular basis of luminosity in this colonial form. These studies have centered primarily on defining the chemical basis for bioluminescence and its control. It is now established that bioluminescence in Renilla arises due to the luciferase-catalyzed oxidation of luciferin. This results in the creation of a product (oxyluciferin) in an electronic excited state. The transition of oxyluciferin from its excited state to the ground state leads to light emission.

Color Change Can Be Earliest Sign of Melanoma

2005 ◽  
Vol 38 (22) ◽  
pp. 16
Author(s):  
TIMOTHY F. KIRN
Keyword(s):  
Color Change

The ground state energy of the ±J spin glass from the genetic algorithm

1994 ◽  
Vol 4 (9) ◽  
pp. 1281-1285 ◽  
Author(s):  
P. Sutton ◽  
D. L. Hunter ◽  
N. Jan
Keyword(s):  
Genetic Algorithm ◽  
Spin Glass ◽  
Ground State Energy ◽  
Ground State ◽  
State Energy

Ground State and Excited State H-Atom Temperatures in a Microwave Plasma Diamond Deposition Reactor

1996 ◽  
Vol 6 (9) ◽  
pp. 1167-1180 ◽  
Author(s):  
A. Gicquel ◽  
M. Chenevier ◽  
Y. Breton ◽  
M. Petiau ◽  
J. P. Booth ◽  
...  
Keyword(s):  
Excited State ◽  
Ground State ◽  
Microwave Plasma ◽  
Diamond Deposition
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