scholarly journals Fluorinated molecular beacons as functional DNA nanomolecules for cellular imaging

2017 ◽  
Vol 8 (10) ◽  
pp. 7082-7086 ◽  
Author(s):  
Cheng Jin ◽  
Ting Fu ◽  
Ruowen Wang ◽  
Hui Liu ◽  
Jianmei Zou ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Small Molecules ◽  
Cellular Imaging ◽  
Molecular Beacons ◽  
Functional Dna

Molecular beacons (MBs) are simple, but practical, fluorescent nanoprobes widely used to detect small molecules, nucleic acids and proteins.

Allosteric Molecular Beacons for Sensitive Detection of Nucleic Acids, Proteins, and Small Molecules in Complex Biological Samples

2011 ◽  
Vol 17 (33) ◽  
pp. 9042-9046 ◽  
Author(s):  
Yanling Song ◽  
Liang Cui ◽  
Jie Wu ◽  
Weiting Zhang ◽  
Wei Yun Zhang ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Small Molecules ◽  
Biological Samples ◽  
Molecular Beacons ◽  
Sensitive Detection

scholarly journals Click-ExM enables expansion microscopy for all biomolecules

2020 ◽  
Author(s):  
De-en Sun ◽  
Xinqi Fan ◽  
Hao Zhang ◽  
Zhimin Huang ◽  
Qi Tang ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Small Molecules ◽  
Signal Amplification ◽  
Super Resolution ◽  
Cellular Imaging ◽  
One Stop ◽  
Nanoscale Imaging ◽  
Resolution Imaging

Expansion microscopy (ExM) allows super-resolution imaging on conventional fluorescence microscopes, but has been limited to proteins and nucleic acids. Here we develop click-ExM, which integrates click-labeling into ExM to enable a “one-stop-shop” method for nanoscale imaging of various types of biomolecules. Using 18 clickable labels for click-ExM imaging of DNA, RNA, proteins, lipids, glycans and small molecules, we demonstrate its universality, compatibility with signal-amplification techniques, and broad applications in cellular imaging.

Structural Insights into the Recognition of DNA Defects by Small Molecules

2021 ◽  
Author(s):  
David Dayanidhi Paul Elisa Sundar ◽  
Vaidyanathan Ganesan
Keyword(s):  
Nucleic Acids ◽  
Metal Complexes ◽  
Small Molecules ◽  
Chemical Properties ◽  
Biological Applications ◽  
Binding Interaction ◽  
Structural Insights

Studies on the binding interaction of small molecules and nucleic acids have been explored for their biological applications. With excellent photophysical/chemical properties, numerous metal complexes have been studied as structural...

scholarly journals The energetics of small molecules binding with nucleic acids

2019 ◽  
Vol 139 ◽  
pp. 105887
Author(s):  
Viktor V. Kostjukov ◽  
Maxim P. Evstigneev
Keyword(s):  
Nucleic Acids ◽  
Small Molecules

scholarly journals Carbon-based dots for electrochemiluminescence sensing

2020 ◽  
Vol 4 (2) ◽  
pp. 369-385 ◽  
Author(s):  
Ying Chen ◽  
Yue Cao ◽  
Cheng Ma ◽  
Jun-Jie Zhu
Keyword(s):  
Nucleic Acids ◽  
Metal Ions ◽  
Small Molecules ◽  
Analytical Approaches ◽  
Carbon Based

This review summarizes the recent development of ECL sensors based on carbon-based dots. Particularly, various analytical approaches involving metal ions, small molecules, proteins, nucleic acids and cells are thoroughly presented.

scholarly journals How ‘Protein-Docking’ Translates into the New Emerging Field of Docking Small Molecules to Nucleic Acids?

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2749
Author(s):  
Francesca Tessaro ◽  
Leonardo Scapozza
Keyword(s):  
Molecular Docking ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Small Molecules ◽  
Viral Infections ◽  
Therapeutic Potential ◽  
Mrna Level ◽  
Protein Docking ◽  
Structural Nature ◽  
Rigid Docking

In this review, we retraced the ‘40-year evolution’ of molecular docking algorithms. Over the course of the years, their development allowed to progress from the so-called ‘rigid-docking’ searching methods to the more sophisticated ‘semi-flexible’ and ‘flexible docking’ algorithms. Together with the advancement of computing architecture and power, molecular docking’s applications also exponentially increased, from a single-ligand binding calculation to large screening and polypharmacology profiles. Recently targeting nucleic acids with small molecules has emerged as a valuable therapeutic strategy especially for cancer treatment, along with bacterial and viral infections. For example, therapeutic intervention at the mRNA level allows to overcome the problematic of undruggable proteins without modifying the genome. Despite the promising therapeutic potential of nucleic acids, molecular docking programs have been optimized mostly for proteins. Here, we have analyzed literature data on nucleic acid to benchmark some of the widely used docking programs. Finally, the comparison between proteins and nucleic acid targets docking highlighted similarity and differences, which are intrinsically related to their chemical and structural nature.

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