scholarly journals Micro RNA-155 inhibitor as a potential therapeutic strategy for the treatment of acute kidney injury (AKI): a nanomedicine perspective

RSC Advances ◽  
2018 ◽  
Vol 8 (29) ◽  
pp. 15890-15896 ◽  
Author(s):  
Shunjie Chen ◽  
Jianping Shan ◽  
Wei Niu ◽  
Fujun Lin ◽  
Shuang Liu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Effective Treatment ◽  
Therapeutic Strategy ◽  
Kidney Injury ◽  
Micro Rna

In this study, we have prepared miR-155 inhibitor-loaded liposome vesicles for the effective treatment of acute kidney injury.

scholarly journals Remote Ischemic Preconditioning Protects Cisplatin-Induced Acute Kidney Injury through the PTEN/AKT Signaling Pathway

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Wanfen Zhang ◽  
Cheng Chen ◽  
Ran Jing ◽  
Tongqiang Liu ◽  
Bicheng Liu
Keyword(s):  
Acute Kidney Injury ◽  
Ischemic Preconditioning ◽  
Therapeutic Strategy ◽  
Molecular Mechanisms ◽  
Kidney Injury ◽  
Akt Signaling ◽  
Remote Ischemic Preconditioning ◽  
Pten Mrna ◽  
Induce Resistance ◽  
In Cis

Although cisplatin (Cis) is an effective chemotherapeutic agent in treatment of various cancers, its adverse effect of nephrotoxicity limits the clinical application. Remote ischemic preconditioning (RIPC) is a strategy to induce resistance in a target organ against the oxidative stress and injury by applying transient, brief episodes of ischemia. However, whether RIPC exerts protective effect on Cis-induced renal injury remains unclear. In this study, we showed that RIPC significantly alleviated the renal functional and histopathological damage of Cis-induced acute kidney injury (AKI) mice. Furthermore, RIPC substantially reversed the downregulation of miR-144 and upregulation of PTEN in renal tissues of Cis-induced AKI mice and alleviated tubular cell apoptosis via activating PTEN/AKT signaling. In mechanism, we demonstrated that miR-144 directly targets the 3’-UTR of PTEN mRNA, and then the elevation of miR-144 in RIPC activates PTEN/AKT signaling by downregulating PTEN expression to achieve its antiapoptosis effect. Collectively, our results indicate that RIPC may be a potential therapeutic strategy in Cis-induced AKI, and provide insights on the underlying molecular mechanisms of cisplatin’s nephrotoxicity.

scholarly journals Protective Effects of Recombinant Human Soluble Thrombomodulin on Lipopolysaccharide-Induced Acute Kidney Injury

2020 ◽  
Vol 21 (7) ◽  
pp. 2519
Author(s):  
Yuji Nozaki ◽  
Jinhai Ri ◽  
Kenji Sakai ◽  
Kaoru Niki ◽  
Masanori Funauchi ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Damage ◽  
Cell Activation ◽  
Therapeutic Strategy ◽  
Cytokine Production ◽  
Kidney Injury ◽  
Protective Effects ◽  
Inflammatory Cytokine Production ◽  
Soluble Thrombomodulin ◽  
Anticoagulant Function

Thrombomodulin (TM) is a single transmembrane, multidomain glycoprotein receptor for thrombin, and is best known for its role as a cofactor in a clinically important natural anticoagulant pathway. In addition to its anticoagulant function, TM has well-defined anti-inflammatory properties. Soluble TM levels increase significantly in the plasma of septic patients; however, the possible involvement of recombinant human soluble TM (rTM) transduction in the pathogenesis of lipopolysaccharide (LPS)-induced nephrotoxicity, including acute kidney injury (AKI), has remained unclear. Mice were injected intraperitoneally with 15 mg/kg LPS. rTM (3 mg/kg) or saline was administered to the animals before the 3 and 24 h LPS-injection. At 24 and 48 h, blood urea nitrogen, the inflammatory cytokines in sera and kidney, and histological findings were assessed. Cell activation and apoptosis signal was assessed by Western blot analysis. In this study using a mouse model of LPS-induced AKI, we found that rTM attenuated renal damage by reducing both cytokine and cell activation and apoptosis signals with the accumulation of CD4+ T-cells, CD11c+ cells, and F4/80+ cells via phospho c-Jun activations and Bax expression. These findings suggest that the mechanism underlying these effects of TM may be mediated by a reduction in inflammatory cytokine production in response to LPS. These molecules might thereby provide a new therapeutic strategy in the context of AKI with sepsis.

scholarly journals Micro RNA‐30b (inhibitor) nanoparticles suppressed the lipopolysaccharide (LPS)‐induced acute kidney injury

2019 ◽  
Vol 13 (9) ◽  
pp. 923-927 ◽  
Author(s):  
Xiang Shao ◽  
Suhua Zhang ◽  
Ying Tang ◽  
Weixin Kong
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Micro Rna

scholarly journals MO007INDUCTION OF IMMUNOSUPPRESSIVE MICRO-RNA IN SPLEEN ATTENUATES SEPSIS INDUCED ACUTE KIDNEY INJURY

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii44-iii44
Author(s):  
Yoshio Funahashi ◽  
Noritoshi Kato ◽  
Takuji Ishimoto ◽  
Tomoki Kosugi ◽  
Naotake Tsuboi ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Micro Rna

EXPERIENCE OF USING A CELLULAR ENERGY PROTECTOR IN THE COMPLEX TREATMENT OF ACUTE KIDNEY INJURY IN AN ADOLESCENT WITH METAMIZOLE POISONING

2021 ◽  
Vol 100 (3) ◽  
pp. 283-288
Author(s):  
L.А. Kovalenko ◽  
◽  
O.L. Chugunova ◽  
G.N. Sukhodolova ◽  
O.I. Yaroshevskaya ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Conservative Treatment ◽  
Effective Treatment ◽  
Medical Practice ◽  
Pediatric Patients ◽  
Kidney Injury ◽  
Complex Treatment ◽  
Cellular Energy ◽  
Complex Therapy

Every year, 1,700–1,850 pediatric patients apply to the Department of Toxicology of Filatov Children's City Clinical Hospital for specialized medical care. More than 56% of hospitalizations are caused by medicinal poisoning. One of the serious complications of drug intoxication is acute kidney injury (AKI). The incidence of AKI in acute chemical poisoning in childhood is from 10 to 57,6% according to various authors, therefore, the issues of effective treatment of AKI in the medical practice of doctor of any specialty are extremely relevant. The article presents the case of conservative treatment of AKI stage 3 according to the KDIGO classification in a teenager with metamizole poisoning, including inclusion of «Cytoflavin» cellular energy protector as a part of complex therapy. As a result of the treatment, the level of proteinuria and azotemia in the child has decreased. The rate of tuber filtration has increased from 20,0 to 62,4 ml/min/1,73 m2. Thus, the use of a cellular energy protector contributed to effective restoration of renal function.

scholarly journals Genetic Susceptibility to Acute Kidney Injury

2021 ◽  
Vol 10 (14) ◽  
pp. 3039
Author(s):  
Christian Ortega-Loubon ◽  
Pedro Martínez-Paz ◽  
Emilio García-Morán ◽  
Álvaro Tamayo-Velasco ◽  
Francisco J. López-Hernández ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Effective Treatment ◽  
Genetic Factors ◽  
Kidney Injury ◽  
Prevention And Treatment ◽  
Novel Approaches ◽  
Key Genes ◽  
Shed Light

Acute kidney injury (AKI) is a widely held concern related to a substantial burden of morbidity, mortality and expenditure in the healthcare system. AKI is not a simple illness but a complex conglomeration of syndromes that often occurs as part of other syndromes in its wide clinical spectrum of the disease. Genetic factors have been suggested as potentially responsible for its susceptibility and severity. As there is no current cure nor an effective treatment other than generally accepted supportive measures and renal replacement therapy, updated knowledge of the genetic implications may serve as a strategic tactic to counteract its dire consequences. Further understanding of the genetics that predispose AKI may shed light on novel approaches for the prevention and treatment of this condition. This review attempts to address the role of key genes in the appearance and development of AKI, providing not only a comprehensive update of the intertwined process involved but also identifying specific markers that could serve as precise targets for further AKI therapies.

scholarly journals Recovery from Leptospira-Related Acute Liver Failure and Acute Kidney Injury ― A Case Report from Bangladesh

2019 ◽  
Vol 9 (2) ◽  
pp. 136-139
Author(s):  
Akmat Ali ◽  
Richmond Ronald Gomes ◽  
Khadiza Begum
Keyword(s):  
Acute Kidney Injury ◽  
Case Report ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Effective Treatment ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Kidney Injury ◽  
Sudden Onset ◽  
Leptospira Interrogans

Leptospirosis is a zoonosis with protean manifestation caused by the spirochete, Leptospira interrogans. Here we report a 60-year-old male who presented with sudden onset of fever, rigors, myalgia and headache occasionally accompanied by nausea, vomiting and diarrhea. Later during the course of treatment he developed encephalopathy with fulminant hepatic failure and acute kidney injury and was diagnosed as a case of leptospirosis. A timely workup combined with early initiation of antibiotics and hemodialysis led to effective treatment for this patient. J Enam Med Col 2019; 9(2): 136-139

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