scholarly journals SNHG5 promotes proliferation and induces apoptosis in melanoma by sponging miR-155

RSC Advances ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 6160-6168 ◽  
Author(s):  
Lu Yan ◽  
Suihai Wang ◽  
Yue Li ◽  
Linda Tognetti ◽  
Rui Tan ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Host Gene ◽  
Small Nucleolar Rna ◽  
Non Coding Rna ◽  
Tumor Tissues ◽  
Long Non Coding Rna ◽  
Nucleolar Rna ◽  
Common Malignancy

Melanoma is the most common malignancy of skin cancer. Small nucleolar RNA host gene 5 (SNHG5), a long non-coding RNA (lncRNA), has been demonstrated to be upregulated in tumor tissues and cells of melanoma.

scholarly journals Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy

2021 ◽  
Vol 9 ◽  
Author(s):  
Shen Shen ◽  
Yanfang Wang ◽  
Yize Zhang ◽  
Zihui Dong ◽  
Jiyuan Xing
Keyword(s):  
Therapeutic Target ◽  
Molecular Mechanisms ◽  
Clinicopathological Characteristics ◽  
Host Gene ◽  
Loss Of Function ◽  
Small Nucleolar Rna ◽  
Invasion And Migration ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Nucleolar Rna

Small nucleolar RNA host gene 14 (SNHG14) is a long non-coding RNA found to be overexpressed in various types of cancers. Moreover, the expression level of SNHG14 was closely associated with multiple clinicopathological characteristics such as prognosis, tumor differentiation, TNM stage, and lymph node metastasis. Functionally, gain- and loss-of-function of SNHG14 revealed that overexpressed SNHG14 promoted cancer cell viability, invasion, and migration, whereas its down-regulation produced the opposite effect. Mechanistically, regulating its target gene expression by sponging distinct miRNAs might be the major mechanism underlying the oncogenic functions of SNHG14. Thus, SNHG14 might be a promising prognostic biomarker and therapeutic target for cancers. In this review, we discuss the expression profile, biological function, and molecular mechanisms of SNHG14 in cancers to provide a molecular basis for the clinical utility of SNHG14 in the future.

scholarly journals LncRNA SNHG5 regulates the cell viability and apoptosis of glioma cells by the miR-1297/KPNA2 axis

RSC Advances ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 1498-1506
Author(s):  
Xueyuan Li ◽  
Qiankun Liu ◽  
Kang Wang ◽  
Wenzheng Luo ◽  
Tiansong Liang ◽  
...  
Keyword(s):  
Cell Viability ◽  
Glioma Cells ◽  
Host Gene ◽  
Small Nucleolar Rna ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Nucleolar Rna

Long non-coding RNA small nucleolar RNA host gene 5 (lncRNA SNHG5) has been reported to participate in the occurrence and development of glioma.

Sign in / Sign up

Export Citation Format

Share Document