scholarly journals Biological activity and interaction mechanism of the diketopiperazine derivatives as tubulin polymerization inhibitors

RSC Advances ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 1055-1064 ◽  
Author(s):  
Zhenhua Tian ◽  
Yanyan Chu ◽  
Hui Wang ◽  
Lili Zhong ◽  
Mengyan Deng ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Agents ◽  
Interaction Mechanism ◽  
Tubulin Polymerization ◽  
Tubulin Polymerization Inhibitors

Microtubules are a favorable target for development of anticancer agents.

Combretastatin A-4 inspired novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines as tubulin polymerization inhibitors, antimitotic and anticancer agents

MedChemComm ◽  
2014 ◽  
Vol 5 (6) ◽  
pp. 766-782 ◽  
Author(s):  
Nitesh Sanghai ◽  
Vaibhav Jain ◽  
Ranjan Preet ◽  
Somnath Kandekar ◽  
Sarita Das ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cancer Cells ◽  
Anticancer Agents ◽  
Tubulin Polymerization ◽  
Chromosomal Damage ◽  
Tubulin Polymerization Inhibitors

Novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines that exhibit potent tubulin polymerization inhibition, anticancer activity, anti-migration of cancer cells, chromosomal damage, and apoptosis have been developed.

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