scholarly journals Long non-coding RNA PVT1 facilitates cell proliferation by epigenetically regulating FOXF1 in breast cancer

RSC Advances ◽  
2018 ◽  
Vol 8 (5) ◽  
pp. 2740-2750
Author(s):  
Guangcheng Guo ◽  
Fang Wang ◽  
Mingli Han ◽  
Yuanting Gu ◽  
Xin Duan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Non Coding Rna ◽  
Cancer Tissues ◽  
Long Non Coding Rna ◽  
Variant Translocation

Plasmacytoma variant translocation 1 (PVT1) expression was elevated in breast cancer tissues and correlated to breast cancer progression and prognosis.

scholarly journals Long non-coding RNA ROR recruits histone transmethylase MLL1 to up-regulate TIMP3 expression and promote breast cancer progression

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Aixia Hu ◽  
Fan Hong ◽  
Daohong Li ◽  
Yuwei Jin ◽  
Lingfei Kon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Cancer Prognosis ◽  
Non Coding Rna ◽  
Novel Target ◽  
Cancer Tissues ◽  
Long Non Coding Rna

Abstract Background As a significant cause of cancer deaths worldwide, breast cancer continues to be a troublesome malignancy. Long non-coding RNAs (lncRNAs) have been implicated in the development of breast cancer. Abnormal methylation has been associated with unfavorable breast cancer prognosis. Herein, the current study aimed to elucidate the role of lncRNA ROR in breast cancer. Methods RT-qPCR was performed to determine whether lncRNA ROR was highly expressed in breast cancer tissues, while lncRNA ROR expression was detected in both the nuclear and cytoplasm of breast cancer cells. MCF-7 cells were subsequently introduced with oe-lncRNA ROR, sh-lncRNA ROR to explore the effects of lncRNA ROR on cell proliferation, invasion and apoptosis. Results RIP, RNA pull-down and ChIP assays provided evidence suggesting that lncRNA ROR recruited transmethylase MLL1 to promote H3K4 trimethylation that enhanced TIMP3 transcription. The rescue experiments demonstrated that lncRNA ROR knockdown could inhibit the progression of breast cancer via the downregulation of TIMP3. Finally, the in vivo experiment findings consistently highlighted the suppressive effects of lncRNA ROR silencing on tumor growth. Conclusion Taken together, our study demonstrates that silencing of lncRNA ROR inhibits breast cancer progression via repression of transmethylase MLL1 and TIMP3, emphasizing the potential of lncRNA ROR as a novel target against breast cancer.

scholarly journals Long Non-Coding RNA A2M-AS1 Promotes Breast Cancer Progression by Sponging microRNA-146b to Upregulate MUC19

2020 ◽  
Vol Volume 13 ◽  
pp. 1305-1316
Author(s):  
Yuncong Liu ◽  
Qi Zhang ◽  
Jing Wu ◽  
Hanqun Zhang ◽  
Xin Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Upregulation of the long non-coding RNA CBR3-AS1 predicts tumor prognosis and contributes to breast cancer progression

Gene X ◽  
2019 ◽  
Vol 2 ◽  
pp. 100014
Author(s):  
Lingyun Xu ◽  
Hong Zhu ◽  
Fei Gao ◽  
Yinghua Tang ◽  
Yajun Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Non Coding Rna ◽  
Tumor Prognosis ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA SNHG1 activates HOXA1 expression via sponging miR-193a-5p in breast cancer progression

Aging ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 10223-10234 ◽  
Author(s):  
Jun Li ◽  
Tianyu Zeng ◽  
Wei Li ◽  
Hao Wu ◽  
Chunxiao Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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