scholarly journals Efficient synthesis of benzene-fused 6/7-membered amides via Xphos Pd G2 catalyzed intramolecular C–N bond formation

RSC Advances ◽  
2017 ◽  
Vol 7 (82) ◽  
pp. 51972-51977 ◽  
Author(s):  
Zhou Xu ◽  
Ke Li ◽  
Rongliang Zhai ◽  
Ting Liang ◽  
Xiaodie Gui ◽  
...  
Keyword(s):  
Second Generation ◽  
Bond Formation ◽  
Pd Catalyst ◽  
Efficient Synthesis ◽  
Aryl Chlorides ◽  
Efficient Approach ◽  
Intramolecular Amidation

An efficient approach for benzene-fused 6/7-membered amides via intramolecular amidation of aryl chlorides catalyzed by a Buchwald–Hartwig second generation Pd catalyst (Xphos Pd G2) has been successfully developed.

DABCO-Promoted [3+2] annulation for Efficient Synthesis of 1,2,5-Triaryl-1H-imidazoles from Substituted β-Nitrostyrenes and N-Arylbenzimidamides

Synthesis ◽  
2021 ◽  
Author(s):  
Yue Zhang ◽  
Xinyi Wan ◽  
Jianbo Gan ◽  
Cunde Wang
Keyword(s):  
Efficient Synthesis ◽  
Efficient Approach ◽  
Imidazole Derivatives

An efficient approach to the synthesis of 1,2,5-trisubstituted imidazole derivatives was investigated via DABCO-promoted formal [3 + 2] annulation reaction of substituted N-arylbenzimidamide and substituted β-nitrostyrenes. The annulation reaction is implemented easily to afford the corresponding products in moderate to good yields with excellent regioselectivity.

Critical Review of Biotransformational Studies on Steroids by Using Culture of Cunninghamella blakesleeana

2021 ◽  
Vol 18 ◽  
Author(s):  
Azizuddin ◽  
Muhammad Iqbal ◽  
Syed Ghulam Musharraf
Keyword(s):  
Double Bond ◽  
Critical Review ◽  
Structural Modification ◽  
Bond Formation ◽  
Environmentally Friendly ◽  
Side Chain ◽  
Synthetic Compounds ◽  
Efficient Approach ◽  
Cunninghamella Blakesleeana ◽  
Different Strains

: For several decades, biotransformational studies on steroidal compounds have gained a lot of attention because it is an efficient approach for the structural modification of complicated natural or synthetic compounds with high regio-, chemo- and stereoselectivity at environmentally friendly conditions. This review summarizes the use of different strains of Cunninghamella blakesleeana for the biotransformation of sixteen steroids 1-16 into a variety of transformed products. The transformed products may be important as a drug or precursor for the production of important pharmaceuticals. The types of reactions performed by C. blakesleeana include hydroxylation, epoxidation, reduction, demethylation, oxidation, glycosidation, double bond formation, side-chain degradation, isomerisation and opening of an isoxazol ring, which would be difficult to produce by traditional synthesis.

Copper-catalyzed oxidative dehydrogenative N–N bond formation for the synthesis of N,N′-diarylindazol-3-ones

2017 ◽  
Vol 4 (2) ◽  
pp. 229-231 ◽  
Author(s):  
Guo Dai ◽  
Luo Yang ◽  
Wang Zhou
Keyword(s):  
Catalytic System ◽  
Bond Formation ◽  
Efficient Synthesis ◽  
Dehydrogenative Coupling

A general copper/air catalytic system for efficient synthesis of N,N′-diarylindazol-3-ones via oxidative dehydrogenative coupling was developed.

Efficient Synthesis of Chromenes from Vinyl o-Quinone Methides via a Brønsted Acid Catalyzed Electrocyclization Process

Synthesis ◽  
2018 ◽  
Vol 50 (12) ◽  
pp. 2416-2422 ◽  
Author(s):  
Man-Su Tu ◽  
Guang-Jian Mei ◽  
Feng Shi ◽  
Si-Jia Liu ◽  
Xiao-Li Jiang ◽  
...  
Keyword(s):  
Efficient Method ◽  
Research Area ◽  
Environmentally Benign ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Efficient Synthesis ◽  
Quinone Methides ◽  
Efficient Approach ◽  
Brönsted Acid ◽  
Acid Catalyzed

An efficient approach for the synthesis of chromene derivatives from vinyl o-quinone methides was established via a Brønsted acid catalyzed electrocyclization. By using this methodology, a series of structurally diversified chromenes was synthesized in a highly atom-economic and environmentally benign manner with generally good to excellent yields (up to 98% yield). This reaction will not only provide an efficient method for the construction of chromene scaffolds, but also enrich the research area of o-quinone methides.

scholarly journals Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction

2019 ◽  
Vol 15 ◽  
pp. 874-880
Author(s):  
Razieh Navari ◽  
Saeed Balalaie ◽  
Saber Mehrparvar ◽  
Fatemeh Darvish ◽  
Frank Rominger ◽  
...  
Keyword(s):  
Room Temperature ◽  
High Selectivity ◽  
Domino Reaction ◽  
Primary Amines ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
Reaction Conditions ◽  
Efficient Approach ◽  
Three Component Reaction ◽  
High Yields

An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4H-chromen-4-one, malononitrile, primary amines in the presence of Et3N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.

ChemInform Abstract: Gold-Catalyzed Intermolecular C-S Bond Formation: Efficient Synthesis of α-Substituted Vinyl Sulfones.

ChemInform ◽  
2014 ◽  
Vol 45 (44) ◽  
pp. no-no
Author(s):  
Yumeng Xi ◽  
Boliang Dong ◽  
Edward J. McClain ◽  
Qiaoyi Wang ◽  
Tesia L. Gregg ◽  
...  
Keyword(s):  
Bond Formation ◽  
Efficient Synthesis
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