scholarly journals Surface decoration of selenium nanoparticles with curcumin induced HepG2 cell apoptosis through ROS mediated p53 and AKT signaling pathways

RSC Advances ◽  
2017 ◽  
Vol 7 (83) ◽  
pp. 52456-52464 ◽  
Author(s):  
Min Guo ◽  
Yinghua Li ◽  
Zhengfang Lin ◽  
Mingqi Zhao ◽  
Misi Xiao ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Hepg2 Cell ◽  
Cell Apoptosis ◽  
Akt Signaling ◽  
Selenium Nanoparticles ◽  
Apoptotic Signaling ◽  
Surface Decoration

Curcumin surface decorated selenium nanoparticles (Se@Cur) has been described in this study. The apoptotic signaling pathways triggered by the Se@Cur are p53 and AKT pathways.

scholarly journals Multifunctional selenium nanoparticles with Galangin-induced HepG2 cell apoptosis through p38 and AKT signalling pathway

2018 ◽  
Vol 5 (11) ◽  
pp. 180509 ◽  
Author(s):  
Yinghua Li ◽  
Min Guo ◽  
Zhengfang Lin ◽  
Mingqi Zhao ◽  
Yu Xia ◽  
...  
Keyword(s):  
Hepg2 Cell ◽  
Cell Apoptosis ◽  
Hepg2 Cells ◽  
Caspase 3 ◽  
Selenium Nanoparticles ◽  
Potential Candidate ◽  
Common Cancer ◽  
Anti Cancer ◽  
Surface Decoration ◽  
Cancer Activity

The morbidity and mortality of hepatocellular carcinoma, the most common cancer, are increasing continuously worldwide. Galangin (Ga) has been demonstrated to possess anti-cancer effect, but the efficacy of Ga was limited by its low permeability and poor solubility. To develop aqueous formulation and improve the anti-cancer activity of Ga, surface decoration of functionalized selenium nanoparticles with Ga (Se@Ga) was synthesized in the present study. The aim of this study was to evaluate the anti-cancer effect of Se@Ga and the mechanism on HepG2 cells. Se@Ga-induced HepG2 cell apoptosis was confirmed by depletion of mitochondrial membrane potential, translocation of phosphatidylserine and caspase-3 activation. Furthermore, Se@Ga enhanced the anti-cancer activity of HepG2 cells through ROS-mediated AKT and p38 signalling pathways. In summary, these results suggest that Se@Ga might be potential candidate chemotherapy for cancer.

Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways

Neuroscience ◽  
2015 ◽  
Vol 286 ◽  
pp. 242-250 ◽  
Author(s):  
R. Wang ◽  
J. Yang ◽  
L. Peng ◽  
J. Zhao ◽  
N. Mu ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Cell Apoptosis ◽  
Akt Signaling ◽  
Serum Deprivation

scholarly journals Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways

2016 ◽  
Vol 12 (4) ◽  
pp. 2894-2899 ◽  
Author(s):  
Wei-Feng Zhong ◽  
Xiao-Hong Wang ◽  
Bin Pan ◽  
Feng Li ◽  
Lu Kuang ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Cancer Cell ◽  
Renal Cancer ◽  
Cell Apoptosis ◽  
Akt Signaling ◽  
Cancer Cell Apoptosis ◽  
Renal Cancer Cell

scholarly journals Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Bo-Syong Pan ◽  
Yang-Kao Wang ◽  
Meng-Shao Lai ◽  
Yi-Fen Mu ◽  
Bu-Miin Huang
Keyword(s):  
Tumor Cell ◽  
Signaling Pathways ◽  
Cell Apoptosis ◽  
Akt Signaling ◽  
Tumor Cell Apoptosis ◽  
P38 Mapks
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