scholarly journals The mode of antimicrobial action of curcumin depends on the delivery system: monolithic nanoparticles vs. supramolecular inclusion complex

RSC Advances ◽  
2017 ◽  
Vol 7 (67) ◽  
pp. 42559-42569 ◽  
Author(s):  
Ilya Shlar ◽  
Samir Droby ◽  
Ruplal Choudhary ◽  
Victor Rodov
Keyword(s):  
Electron Transport ◽  
Inclusion Complex ◽  
Delivery System ◽  
Antimicrobial Effect ◽  
Antimicrobial Action ◽  
Target Electron ◽  
Cyclodextrin Complexes

Formulation determines curcumin antimicrobial effect: curcumin–cyclodextrin complexes are bactericidal, induce ROS, and target electron transport; monolithic nanoparticles are bacteriostatic, and target membranes and ATP.

scholarly journals Evaluation of the antimicrobial effect of calcium hydroxide combined to different vehicles

2016 ◽  
Vol 31 (2) ◽  
pp. 89
Author(s):  
Tatiana Dantas Piana ◽  
Maria de Fátima Malvar Gesteira ◽  
Erica Dos Santos Carvalho ◽  
Josilene Borges Torres Lima Matos ◽  
Monica Franca ◽  
...  
Keyword(s):  
Calcium Hydroxide ◽  
Enterococcus Faecalis ◽  
Antimicrobial Effect ◽  
Antimicrobial Action ◽  
Diffusion Method ◽  
Agar Diffusion ◽  
Inhibition Zones ◽  
Agar Diffusion Method

Objective: To evaluate the potentiating effect of different substances in antimicrobial action of calcium hydroxide.Methods: The agar diffusion method, was used with well technique, to analyze seven substances associated to calcium hydroxide to make some pastes, they are: chlorexidine, saline, anesthetic, malvatricin, propolis, hypochlorite, paramonochlorophenol.Results: The pastes with malvatricin and paramonochlorophenol presented greater inhibition zones against Enterococcus faecalis.Conclusion: There was potentialization in antimicrobial effect of calcium hydroxide when associated to paramonochlorophenol and to malvatricin especially against Enterococcus faecalis. Low increase of the antimicrobial capacity was observed when using chlorexidine as vehicle to calcium hydroxine paste.

scholarly journals Solution inclusion complexes of cyclodextrins with sodium perfluorooctanoate

1989 ◽  
Vol 67 (10) ◽  
pp. 1550-1553 ◽  
Author(s):  
Ramamurthy Palepu ◽  
Vincent C. Reinsborough
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Goodness Of Fit ◽  
Sodium Ion ◽  
The Other ◽  
Cyclodextrin Complexes ◽  
Fluorocarbon Surfactant ◽  
Other Hand ◽  
Fluorocarbon Chain ◽  
Sodium Perfluorooctanoate

Pre-micellar and micellar sodium perfluorooctanoate solutions (SPFO) were examined conductometrically with added α-cyclodextrin(α-CD), β-cyclodextrin (β-CD), and γ-cyclodextrin (γ-CD). The order of stability of the 1:1 inclusion complex was (β-CD > γ-CD > α-CD determined largely by the goodness of fit of the fluorocarbon chain in the CD cavity. Sodium ion electrode studies revealed that some Na+ ion is associated with the (β-CD/SPFO complex. As shown by fluorine-19 nmr, (β-CD girds the SPFO molecule snugly amidship with the terminal CF3 group still in solution. On the other hand, SPFO manages only a weak penetration of the fluorocarbon chain into the smaller α-CD cavity. Keywords: perflurooctanoate, cyclodextrin complexes, fluorocarbon surfactant, 19F nmr.

scholarly journals Escherichia coli O157 and Non-O157 Isolates Are More Susceptible to l-Lactate than to d-Lactate

2002 ◽  
Vol 68 (9) ◽  
pp. 4676-4678 ◽  
Author(s):  
E. C. McWilliam Leitch ◽  
C. S. Stewart
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Effect ◽  
Membrane Potentials ◽  
Antimicrobial Action ◽  
Escherichia Coli O157

ABSTRACT The antimicrobial effect of l-lactate was much greater than that of d-lactate over a range of concentrations for Escherichia coli O157 and non-O157 strains. Despite this, the intracellular pHs and membrane potentials of l-lactate- and d-lactate-treated cells were similar, suggesting that these factors are not involved in the antimicrobial action of l-lactate.

Antimicrobial Effect of α- or β-Cyclodextrin Complexes withTrans-Cinnamaldehyde AgainstStaphylococcus aureusandEscherichia coli

2015 ◽  
Vol 33 (3) ◽  
pp. 377-383 ◽  
Author(s):  
Ji-Yeon Chun ◽  
Yeon-Ji Jo ◽  
Piyawan Bjrapha ◽  
Mi-Jung Choi ◽  
Sang-Gi Min
Keyword(s):  
Antimicrobial Effect ◽  
Cyclodextrin Complexes

Prediction of the Effects of Inoculum Size on the Antimicrobial Action of Trovafloxacin and Ciprofloxacin againstStaphylococcus aureus and Escherichia coli in an In Vitro Dynamic Model

1999 ◽  
Vol 43 (3) ◽  
pp. 498-502 ◽  
Author(s):  
Alexander A. Firsov ◽  
Sergey N. Vostrov ◽  
Olga V. Kononenko ◽  
Stephen H. Zinner ◽  
Yury A. Portnoy
Keyword(s):  
Escherichia Coli ◽  
Dynamic Models ◽  
Antimicrobial Effect ◽  
Inoculum Size ◽  
Antimicrobial Action ◽  
Time Curve ◽  
Mean Values ◽  
E Coli ◽  
Inoculum Effect

ABSTRACT The effect of inoculum size (N 0) on antimicrobial action has not been extensively studied in in vitro dynamic models. To investigate this effect and its predictability, killing and regrowth kinetics of Staphylococcus aureus andEscherichia coli exposed to monoexponentially decreasing concentrations of trovafloxacin (as a single dose) and ciprofloxacin (two doses at a 12-h interval) were compared atN 0 = 106 and 109 CFU/ml (S. aureus) and at N 0 = 106, 107, and 109 CFU/ml (E. coli). A series of pharmacokinetic profiles of trovafloxacin and ciprofloxacin with respective half-lives of 9.2 and 4 h were simulated at different ratios of area under the concentration-time curve (AUC) to MIC (in [micrograms × hours/milliliter]/[micrograms/milliliter]): 58 to 466 with trovafloxacin and 116 to 932 with ciprofloxacin for S. aureus and 58 to 233 and 116 to 466 for E. coli, respectively. Although the effect of N 0 was more pronounced for E. coli than for S. aureus, only a minor increase in minimum numbers of surviving bacteria and an almost negligible delay in their regrowth were associated with an increase of the N 0 for both organisms. TheN 0-induced reductions of the intensity of the antimicrobial effect (IE , area between control growth and the killing-regrowth curves) were also relatively small. However, the N 0 effect could not be eliminated either by simple shifting of the time-kill curves obtained at higherN 0s by the difference between the higher and lowest N 0 or by operating withIE s determined within theN 0-adopted upper limits of bacterial numbers (IE ′s). By using multivariate correlation and regression analyses, linear relationships betweenIE and log AUC/MIC and logN 0 related to the respective mean values [(log AUC/MIC)average and (logN 0)average] were established for both trovafloxacin and ciprofloxacin against each of the strains (r 2 = 0.97 to 0.99). The antimicrobial effect may be accurately predicted at a given AUC/MIC of trovafloxacin or ciprofloxacin and at a given N 0 based on the relationship IE = a + b [(log AUC/MIC)/(log AUC/MIC)average] − c [(logN 0)/(logN 0)average]. Moreover, the relative impacts of AUC/MIC and N 0 onIE may be evaluated. Since the c/bratios for trovafloxacin and ciprofloxacin against E. coliwere much lower (0.3 to 0.4) than that for ampicillin-sulbactam as examined previously (1.9), the inoculum effect with the quinolones may be much less pronounced than with the β-lactams. The described approach to the analysis of the inoculum effect in in vitro dynamic models might be useful in studies with other antibiotic classes.

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