scholarly journals Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles

RSC Advances ◽  
2017 ◽  
Vol 7 (38) ◽  
pp. 23827-23834 ◽  
Author(s):  
F. Benyettou ◽  
H. Fahs ◽  
R. Elkharrag ◽  
R. A. Bilbeisi ◽  
B. Asma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Iron Oxide Nanoparticles ◽  
Delivery System ◽  
Oxide Nanoparticles ◽  
Doxorubicin Hydrochloride ◽  
System P

Cucurbit[7]uril-modified iron-oxide nanoparticles (CB[7]NPs) were loaded with doxorubicin hydrochloride (Dox) and tested as a drug delivery system.

scholarly journals Chlorambucil-Iron Oxide Nanoparticles as a Drug Delivery System for Leukemia Cancer Cells

2021 ◽  
Vol Volume 16 ◽  
pp. 6205-6216
Author(s):  
Samer Hasan Hussein-Al-Ali ◽  
Mohd Zobir Hussein ◽  
Saifullah Bullo ◽  
Palanisamy Arulselvan
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Iron Oxide Nanoparticles ◽  
Delivery System ◽  
Oxide Nanoparticles

Polymer Coated Iron Nanoparticles: Radiolabeling & In Vitro Studies

2020 ◽  
Vol 13 ◽  
Author(s):  
Selin Yılmaz ◽  
Çiğdem İçhedef ◽  
Kadriye Buşra Karatay ◽  
Serap Teksöz
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Sem Images

Backgorund: Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used for targeted drug delivery systems due to their unique magnetic properties. Objective: In this study, it’s aimed to develop a novel targeted 99mTc radiolabeled polymeric drug delivery system for Gemcitabine (GEM). Methods: Gemcitabine, an anticancer agent, was encapsulated into polymer nanoparticles (PLGA) together with iron oxide nanoparticles via double emulsion technique and then labeled with 99mTc. SPIONs were synthesized by reduction–coprecipitation method and encapsulated with oleic acid for surface modification. Size distribution and the morphology of the synthesized nanoparticles were caharacterized by dynamic light scattering(DLS)and scanning electron microscopy(SEM), respectively. Radiolabeling yield of SPION-PLGAGEM nanoparticles were determined via Thin Layer Radio Chromatography (TLRC). Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells in vitro. Results: SEM images displayed that the average size of the drug-free nanoparticles was 40 nm and the size of the drug-loaded nanoparticles was 50 nm. The diameter of nanoparticles were determined as 366.6 nm by DLS, while zeta potential was found as-29 mV. SPION was successfully coated with PLGA, which was confirmed by FTIR. GEM encapsulation efficiency of SPION-PLGA was calculated as 4±0.16 % by means of HPLC. Radiolabeling yield of SPION-PLGA-GEM nanoparticles were determined as 97.8±1.75 % via TLRC. Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells. SPION-PLGA-GEM showed high uptake on MCF-7, whilst incorporation rate was increased for both cell lines which external magnetic field application. Conclusion: 99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and supermagnetic characteristics.

Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells

2016 ◽  
Vol 27 (6) ◽  
pp. 065103 ◽  
Author(s):  
Antonio Aires ◽  
Sandra M Ocampo ◽  
Bruno M Simões ◽  
María Josefa Rodríguez ◽  
Jael F Cadenas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles
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