Recent advances in the intramolecular Mannich reaction in natural products total synthesis

2018 ◽  
Vol 5 (6) ◽  
pp. 1049-1066 ◽  
Author(s):  
Yingbo Shi ◽  
Qiaoling Wang ◽  
Shuanhu Gao
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Mannich Reaction ◽  
Recent Advances

This review focuses on selected applications of the intramolecular Mannich reaction as a key step in the total synthesis of natural products (2000–2017).

Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products

2019 ◽  
Vol 17 (31) ◽  
pp. 7270-7292 ◽  
Author(s):  
Sagar S. Thorat ◽  
Ravindar Kontham
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Natural Product ◽  
Medicinal Chemistry ◽  
Natural Product Chemistry ◽  
Structural Motifs ◽  
Recent Advances ◽  
Synthetic Molecules ◽  
Product Chemistry

Oxaspirolactones are ubiquitous structural motifs found in natural products and synthetic molecules with a diverse biochemical and physicochemical profile, and represent a valuable target in natural product chemistry and medicinal chemistry.

scholarly journals The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry

2020 ◽  
Vol 37 (11) ◽  
pp. 1511-1531
Author(s):  
Zhi-Chen Wu ◽  
Dale L. Boger
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Medicinal Chemistry ◽  
Recent Advances ◽  
The Impact

This review summarizes and highlights recent advances in medicinal chemistry of natural products enabled by total synthesis that provide “supernatural products” with improved properties superseding the natural products themselves.

ChemInform Abstract: Recent Advances in the Total Synthesis of Cyclopropane-Containing Natural Products

ChemInform ◽  
2012 ◽  
Vol 43 (42) ◽  
pp. no-no
Author(s):  
David Y.-K. Chen ◽  
Rebecca H. Pouwer ◽  
Jean-Alexandre Richard
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Recent Advances

Recent Advances in the Total Synthesis of Natural Products Containing Eight-Membered Carbocycles (2009–2019)

2020 ◽  
Vol 120 (13) ◽  
pp. 5910-5953 ◽  
Author(s):  
Ya-Jian Hu ◽  
Li-Xuan Li ◽  
Jing-Chun Han ◽  
Long Min ◽  
Chuang-Chuang Li
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Recent Advances

Recent Advances in the Chemistry of Doubly Activated Cyclopropanes: Synthesis and Reactivity

2019 ◽  
Vol 23 (3) ◽  
pp. 276-312 ◽  
Author(s):  
Purushothaman Gopinath ◽  
Srinivasan Chandrasekaran
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Electron Donor ◽  
Ring Opening ◽  
Dipolar Cycloaddition ◽  
Recent Advances ◽  
Donor Acceptor ◽  
Synthesis Reactions ◽  
Donor Substituent ◽  
Electron Donor Substituent

Diactivated cyclopropanes containing two geminal electron withdrawing groups, commonly called as ‘Doubly Activated Cyclopropanes’ are useful synthons for the synthesis of many interesting natural products and functionalized molecules. These geminal electron withdrawing groups (EWG’s) facilitate the regioselective ring opening of cyclopropanes by polarizing the C-C bond adjacent to it. This polarization also allows them to undergo 1,3 dipolar cycloaddition reactions when substituted with a suitable electron donor substituent at the adjacent carbon (donor-acceptor cyclopropanes) in the presence of suitable dipolarophiles. In this review, we discuss the recent advances in the chemistry of doubly activated cyclopropanes: their synthesis, reactions and applications in total synthesis.

Recent advances in the total synthesis of cyclopropane-containing natural products

2012 ◽  
Vol 41 (13) ◽  
pp. 4631 ◽  
Author(s):  
David Y.-K. Chen ◽  
Rebecca H. Pouwer ◽  
Jean-Alexandre Richard
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Recent Advances

The intramolecular Diels–Alder reaction: recent advances and synthetic applications

1984 ◽  
Vol 62 (2) ◽  
pp. 183-234 ◽  
Author(s):  
Alex G. Fallis
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Alder Reaction ◽  
Diels Alder ◽  
Synthetic Strategy ◽  
Diels Alder Reaction ◽  
Recent Advances ◽  
Cyclic Dienes

Recent advances and examples of the intramolecular Diels–Alder reaction are summarized and applications to the total synthesis of natural products, both completed and in progress, noted. A detailed discussion of trienes leading to bicyclo[4.3.0]nonene skeletons is followed by examples of bicyclo[4.4.0]decenes and adducts arising from ortho-quinodimethane precursors. Cycloadditions affording bicyclo[n.4.0] systems and bridged-ring adducts from cyclic dienes conclude this survey which is followed by a discussion of unreactive trienes and a brief analysis of synthetic strategy to complete the review.

scholarly journals Recent advances in the total synthesis of cyclobutane-containing natural products

2020 ◽  
Vol 7 (1) ◽  
pp. 136-154 ◽  
Author(s):  
Jinshan Li ◽  
Kai Gao ◽  
Ming Bian ◽  
Hanfeng Ding
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Recent Advances ◽  
Recent Developments

Recent developments of strategies on the construction of cyclobutanes and their application in complex natural product synthesis are discussed.

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