“Y”-shape armed amphiphilic star-like copolymers: design, synthesis and dual-responsive unimolecular micelle formation for controlled drug delivery

2017 ◽  
Vol 8 (36) ◽  
pp. 5611-5620 ◽  
Author(s):  
Xiaoshan Fan ◽  
Xiaoyuan Wang ◽  
Mengya Cao ◽  
Chenguang Wang ◽  
Zhiguo Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Micelle Formation ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Design Synthesis ◽  
Dual Responsive

Dual stimuli-responsive unimolecular micelles from “Y”-shape armed amphiphilic star-like copolymer are designed for controlled drug delivery.

Poly(ε-caprolactone) with pH and UCST responsiveness as a 5-fluorouracil carrier

2020 ◽  
Vol 11 (32) ◽  
pp. 5173-5180
Author(s):  
Shuang Zhu ◽  
Lianlei Wen ◽  
Yan Xiao ◽  
Meidong Lang
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Stimuli-responsive polymers with excellent biocompatibility and biodegradability are highly demanded as carriers for controlled drug delivery.

Stimuli-responsive poly(ionic liquid) nanoparticles for controlled drug delivery

2020 ◽  
Vol 8 (35) ◽  
pp. 7994-8001 ◽  
Author(s):  
Beibei Lu ◽  
Gaoxin Zhou ◽  
Fan Xiao ◽  
Qianjun He ◽  
Jiaheng Zhang
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Spherical Nanoparticles ◽  
High Drug ◽  
Good Ability ◽  
Poly Ionic Liquid ◽  
High Drug Loading

A novel poly(ionic liquid) (PIL)-based block copolymer, which can self-assemble into spherical nanoparticles, high drug loading content, and good ability to inhibit tumors. Therefore, this copolymer shows great potential for drug delivery. 

scholarly journals Morphology-tunable and pH-responsive supramolecular self-assemblies based on AB2-type host–guest-conjugated amphiphilic molecules for controlled drug delivery

2019 ◽  
Vol 15 ◽  
pp. 1925-1932 ◽  
Author(s):  
Yang Bai ◽  
Cai-ping Liu ◽  
Di Chen ◽  
Long-hai Zhuo ◽  
Huai-tian Bu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Controlled Drug Delivery ◽  
Transition Process ◽  
Hydrodynamic Diameter ◽  
Cancer Cell Proliferation ◽  
Acidic Ph ◽  
Stimuli Responsive ◽  
Amphiphilic Molecules ◽  
Acidic Conditions

Although stimuli-responsive supramolecular self-assemblies have been constructed, the controlled drug delivery induced by morphology transitions of these supramolecular self-assemblies on the basis of host–guest-conjugated monomers (HGCMs) are few reported. In this paper, the self-assembly behaviors of AB2-type HGCMs, e.g., β-cyclodextrin-benzimidazole2 (β-CD-BM2), were investigated at neutral and acidic pH conditions, respectively. Specifically, β-CD-BM2 first self-assembled into fan-shaped supramolecular self-assemblies with a hydrodynamic diameter of 163 nm at neutral pH, whereas they were further dissociated into spherical supramolecular self-assemblies with a size of 52 nm under acidic conditions. This morphology transition process was utilized to conduct a two-stage DOX delivery under neutral and acidic pH. Basic cell experiments demonstrated that the drug-loaded β-CD-BM2-based supramolecular self-assemblies with varied morphology could inhibit cancer cell proliferation, indicating their potential application in the field of drug delivery.

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