A self-defensive bilayer hydrogel coating with bacteria triggered switching from cell adhesion to antibacterial adhesion

2017 ◽  
Vol 8 (35) ◽  
pp. 5344-5353 ◽  
Author(s):  
Min He ◽  
Qian Wang ◽  
Weifeng Zhao ◽  
Jianshu Li ◽  
Changsheng Zhao
Keyword(s):  
Cell Adhesion ◽  
Bacterial Infection ◽  
Bilayer Coating ◽  
A Cell ◽  
Cell Adhesion And Proliferation ◽  
Hydrogel Coating ◽  
Promote Cell Adhesion

(1) A self-defensive bacterial infection responsive bilayer hydrogel coating was designed; (2) the bilayer coating could promote cell adhesion and proliferation; and (3) the surface showed bacterial infection sensitive switching from a cell adhesion surface to an antibacterial adhesion surface by detaching the upper layer.

scholarly journals Folic acid modified clay/polymer nanocomposites for selective cell adhesion

2014 ◽  
Vol 2 (37) ◽  
pp. 6412-6421 ◽  
Author(s):  
F. B. Barlas ◽  
D. Ag Seleci ◽  
M. Ozkan ◽  
B. Demir ◽  
M. Seleci ◽  
...  
Keyword(s):  
Cell Culture ◽  
Cell Adhesion ◽  
Folic Acid ◽  
Polymer Nanocomposites ◽  
Promising Material ◽  
Modified Clay ◽  
A Cell ◽  
Cell Adhesion And Proliferation

A promising material, a folic acid modified poly(epsilon-caprolactone)/clay nanocomposite that allows selective cell adhesion and proliferation, was synthesized and characterized as a cell culture and biosensing platform.

scholarly journals Amine-Rich Coatings to Potentially Promote Cell Adhesion, Proliferation and Differentiation, and Reduce Microbial Colonization: Strategies for Generation and Characterization

Coatings ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 983
Author(s):  
Laurine Martocq ◽  
Timothy E. L. Douglas
Keyword(s):  
Cell Adhesion ◽  
Antimicrobial Properties ◽  
Microbial Colonization ◽  
Ammonia Gas ◽  
Proliferation And Differentiation ◽  
Biomaterial Surface ◽  
Important Approach ◽  
Cell Support ◽  
Cell Adhesion And Proliferation ◽  
Promote Cell Adhesion

Biomaterial surface modification represents an important approach to obtain a better integration of the material in surrounding tissues. Different techniques are focused on improving cell support as well as avoiding efficiently the development of infections, such as by modifying the biomaterial surface with amine groups (–NH2). Previous studies showed that –NH2 groups could promote cell adhesion and proliferation. Moreover, these chemical functionalities may be used to facilitate the attachment of molecules such as proteins or to endow antimicrobial properties. This mini-review gives an overview of different techniques which have been used to obtain amine-rich coatings such as plasma methods and adsorption of biomolecules. In fact, different plasma treatment methods are commonly used with ammonia gas or by polymerization of precursors such as allylamine, as well as coatings of proteins (for example, collagen) or polymers containing –NH2 groups (for example, polyethyleneimine). Moreover, this mini-review will present the methods used to characterize such coatings and, in particular, quantify the –NH2 groups present on the surface by using dyes or chemical derivatization methods.

scholarly journals Identification of Novel FNIN2 and FNIN3 Fibronectin-Derived Peptides That Promote Cell Adhesion, Proliferation and Differentiation in Primary Cells and Stem Cells

2021 ◽  
Vol 22 (6) ◽  
pp. 3042
Author(s):  
Eun Ju Lee ◽  
Khurshid Ahmad ◽  
Shiva Pathak ◽  
SunJu Lee ◽  
Mohammad Hassan Baig ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Culture ◽  
Cell Adhesion ◽  
3D Culture ◽  
Human Mesenchymal Stem Cells ◽  
Cell Types ◽  
Primary Cells ◽  
Cell Culture Techniques ◽  
Culture Techniques ◽  
Promote Cell Adhesion

In recent years, a major rise in the demand for biotherapeutic drugs has centered on enhancing the quality and efficacy of cell culture and developing new cell culture techniques. Here, we report fibronectin (FN) derived, novel peptides fibronectin-based intergrin binding peptide (FNIN)2 (18-mer) and FNIN3 (20-mer) which promote cell adhesion proliferation, and the differentiation of primary cells and stem cells. FNIN2 and 3 were designed based on the in silico interaction studies between FN and its receptors (integrin α5β1, αvβ3, and αIIbβ3). Analysis of the proliferation of seventeen-cell types showed that the effects of FNINs depend on their concentration and the existence of expressed integrins. Significant rhodamine-labeled FNIN2 fluorescence on the membranes of HeLa, HepG2, A498, and Du145 cells confirmed physical binding. Double coating with FNIN2 or 3 after polymerized dopamine (pDa) or polymerized tannic acid (pTA) precoating increased HBEpIC cell proliferation by 30–40 percent, suggesting FNINs potently affect primary cells. Furthermore, the proliferation of C2C12 myoblasts and human mesenchymal stem cells (MSCs) treated with FNINs was significantly increased in 2D/3D culture. FNINs also promoted MSC differentiation into osteoblasts. The results of this study offer a new approach to the production of core materials (e.g., cell culture medium components, scaffolds) for cell culture.

Silk-based hybrid microfibrous mats as guided bone regeneration membranes

2021 ◽  
Author(s):  
Mi Wu ◽  
Zhengyi Han ◽  
Wen Liu ◽  
Jinrong Yao ◽  
Bingjiao Zhao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cell Adhesion ◽  
Bone Regeneration ◽  
Silk Fibroin ◽  
Guided Bone Regeneration ◽  
Regenerated Silk Fibroin ◽  
Marrow Mesenchymal Stem Cells ◽  
Cell Adhesion And Proliferation

LAPONITE® (LAP) nanoplatelets were incorporated within a regenerated silk fibroin (RSF) microfibrous mat via electrospinning, which exhibited better cell adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs) than the pristine RSF ones.

Function and Histopathology of a Cell Adhesion Molecule TSLC1 in Cancer

2011 ◽  
Vol 29 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Qi-Lian Liang ◽  
Guo-Qiang Chen ◽  
Zhou-Yu Li ◽  
Bi-Rong Wang
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
A Cell
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