The para-fluoro-thiol reaction as a powerful tool for precision network synthesis

2017 ◽  
Vol 8 (25) ◽  
pp. 3778-3782 ◽  
Author(s):  
Federica Cavalli ◽  
Hatice Mutlu ◽  
Sven O. Steinmueller ◽  
Leonie Barner
Keyword(s):  
Network Formation ◽  
Network Synthesis ◽  
Tof Sims ◽  
Novel Strategy ◽  
Thiol Reaction

We introduce the regioselective para-fluoro-thiol reaction (PFTR) as a novel strategy for precision network formation evidenced by XPS and ToF-SIMS.

scholarly journals Kinetic Assembly of a Thermally Stable Porous Coordination Network

2014 ◽  
Vol 70 (a1) ◽  
pp. C1246-C1246
Author(s):  
Hakuba Kitagawa ◽  
Hiroyoshi Ohtsu ◽  
Masaki Kawano
Keyword(s):  
Network Formation ◽  
Covalent Bond ◽  
The Other ◽  
Helical Chain ◽  
Network Synthesis ◽  
Thermally Stable ◽  
Slow Cooling ◽  
Coordination Network ◽  
Other Hand ◽  
Metal Sources

The advantage of porous coordination network synthesis is designability by changing metal sources and ligands.[1] Therefore, not only many commercially available ligands but also newly synthesized ones were used for networking. On the other hand, most of metal sources are common reagents or stable metal moieties because they can be more predictable as a metal connector. So far, there is no report focusing on usage of labile metal sources for selective network formation. One of the promising methods to produce unique networks with such labile metal sources is kinetic control[2] because labile metal sources produce various species in solution. In this talk, we will introduce selective syntheses of thermally stable porous coordination networks using a labile Cu4I4 cubane cluster [Cu4I4(PPh3)4] (1) and a rigid tetradentate Td-symmetry ligand tetra-(4-(4-pyridyl)phenyl)methane (2) by kinetic and thermodynamic control.[3] On heating the mixture of 1 and 2 in DMSO at 453 K, a homogenous colorless solution was obtained. Rapid cooling (~20 Kmin-1) of the solution produced yellow needle crystals, {[(CuI)2(2)]·solvent}n (3a) that shows novel CuI helical chain unit, in 99% yield (Fig. A). On the other hand, slow cooling (~3 Kmin-1) produced orange block crystals, {[(Cu2I2)(2)]·solvent}n (3b) that shows rhombic Cu2I2 dimer unit, in 95% yield. Both the network crystals can keep the crystallinity up to 673 K under N2 atmosphere. In kinetic product 3a, due to the unique structure, iodides of the CuI chains facing to 1D channel, the network crystal shows chemisorption of I2 by making a covalent bond with an iodide of part of the CuI chains to form an I3– group (Fig. B). On the other hand, in thermodynamic product 3b, Cu2I2 dimer units are hindered by bridging ligand 2. That is why network crystal 3b shows only physisorption of I2, even though network has 1D channel similar to 3a.

Applications of Time-OF-Flight Secondary Ion Mass Spectrometry (TOF-SIMS)

1990 ◽  
Vol 48 (2) ◽  
pp. 308-309
Author(s):  
Bruno Schueler ◽  
Robert W. Odom
Keyword(s):  
Mass Spectrometry ◽  
Secondary Ion Mass Spectrometry ◽  
Structural Information ◽  
Time Of Flight ◽  
Biological Tissues ◽  
Polymer Surfaces ◽  
Tof Sims ◽  
Secondary Ions ◽  
Ion Mass Spectrometry ◽  
Secondary Ion

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) provides unique capabilities for elemental and molecular compositional analysis of a wide variety of surfaces. This relatively new technique is finding increasing applications in analyses concerned with determining the chemical composition of various polymer surfaces, identifying the composition of organic and inorganic residues on surfaces and the localization of molecular or structurally significant secondary ions signals from biological tissues. TOF-SIMS analyses are typically performed under low primary ion dose (static SIMS) conditions and hence the secondary ions formed often contain significant structural information.This paper will present an overview of current TOF-SIMS instrumentation with particular emphasis on the stigmatic imaging ion microscope developed in the authors’ laboratory. This discussion will be followed by a presentation of several useful applications of the technique for the characterization of polymer surfaces and biological tissues specimens. Particular attention in these applications will focus on how the analytical problem impacts the performance requirements of the mass spectrometer and vice-versa.

The Collaborative Network Approach: a model for advancing patient-centric research for Castleman disease and other rare diseases

2019 ◽  
Vol 3 (1) ◽  
pp. 97-105
Author(s):  
Mary Zuccato ◽  
Dustin Shilling ◽  
David C. Fajgenbaum
Keyword(s):  
Rare Diseases ◽  
Treatment Options ◽  
Castleman Disease ◽  
High Impact ◽  
Collaborative Network ◽  
Network Approach ◽  
Grant Applications ◽  
Research Questions ◽  
Novel Strategy ◽  
Patient Centric

Abstract There are ∼7000 rare diseases affecting 30 000 000 individuals in the U.S.A. 95% of these rare diseases do not have a single Food and Drug Administration-approved therapy. Relatively, limited progress has been made to develop new or repurpose existing therapies for these disorders, in part because traditional funding models are not as effective when applied to rare diseases. Due to the suboptimal research infrastructure and treatment options for Castleman disease, the Castleman Disease Collaborative Network (CDCN), founded in 2012, spearheaded a novel strategy for advancing biomedical research, the ‘Collaborative Network Approach’. At its heart, the Collaborative Network Approach leverages and integrates the entire community of stakeholders — patients, physicians and researchers — to identify and prioritize high-impact research questions. It then recruits the most qualified researchers to conduct these studies. In parallel, patients are empowered to fight back by supporting research through fundraising and providing their biospecimens and clinical data. This approach democratizes research, allowing the entire community to identify the most clinically relevant and pressing questions; any idea can be translated into a study rather than limiting research to the ideas proposed by researchers in grant applications. Preliminary results from the CDCN and other organizations that have followed its Collaborative Network Approach suggest that this model is generalizable across rare diseases.

Design and Optimization of a Novel Strategy for the Local Treatment of Helicobacter pylori Infections

2020 ◽  
Author(s):  
Taddese Mekonnen Ambay ◽  
Philipp Schick ◽  
Michael Grimm ◽  
Maximilian Sager ◽  
Felix Schneider ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Local Treatment ◽  
Design And Optimization ◽  
Novel Strategy

L cell stimulation: a novel strategy for oral peptide delivery in incretin-based diabetes treatment

2020 ◽  
Author(s):  
Ana Beloqui ◽  
Francesco Suriano ◽  
Matthias Hul ◽  
Yining Xu ◽  
Véronique Préat ◽  
...  
Keyword(s):  
Peptide Delivery ◽  
Diabetes Treatment ◽  
Cell Stimulation ◽  
Oral Peptide Delivery ◽  
L Cell ◽  
Novel Strategy

Platelet Microtubules in Clot Structure Formation and Contractile Force Generation: Investigation of a Controversy

1986 ◽  
Vol 56 (01) ◽  
pp. 023-027 ◽  
Author(s):  
C J Jen ◽  
L V McIntire
Keyword(s):  
Network Formation ◽  
Contractile Force ◽  
Second Phase ◽  
Clot Retraction ◽  
Forming Process ◽  
Microtubule Organization ◽  
Physiological Processes ◽  
Fibrin Network ◽  
Two Parameters

SummaryWhether platelet microtubules are involved in clot retraction/ contraction has been controversial. To address this question we have simultaneously measured two clotting parameters, clot structural rigidity and isometric contractile force, using a rheological technique. For recalcified PRP clots these two parameters began rising together at about 15 min after CaCl2 addition. In the concentration range affecting microtubule organization in platelets, colchicine, vinca alkaloids and taxol demonstrated insignificant effects on both clotting parameters of a recalcified PRP clot. For PRP clots induced by adding small amounts of exogenous thrombin, the kinetic curves of clot rigidity were biphasic and without a lag time. The first phase corresponded to a platelet-independent network forming process, while the second phase corresponded to a platelet-dependent process. These PRP clots began generating contractile force at the onset of the second phase. For both rigidity and force parameters, only the second phase of clotting kinetics was retarded by microtubule affecting reagents. When PRP samples were clotted by adding a mixture of CaCl2 and thrombin, the second phase clotting was accelerated and became superimposed on the first phase. The inhibitory effects of micro tubule affecting reagents became less pronounced. Thrombin clotting of a two-component system (washed platelets/ purified fibrinogen) was also biphasic, with the second phase being microtubule-dependent. In conclusion, platelet microtubules are important in PRP clotted with low concentrations of thrombin, during which fibrin network formation precedes platelet-fibrin interactions. On the other hand they are unimportant if a PRP clot is induced by recalcification, during which the fibrin network is constructed in the presence of platelet-fibrin interactions. The latter is likely to be more analogous to physiological processes in vivo.

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