PAA-g-PLA amphiphilic graft copolymer: synthesis, self-assembly, and drug loading ability

2017 ◽  
Vol 8 (28) ◽  
pp. 4098-4107 ◽  
Author(s):  
Wenhao Qian ◽  
Tao Song ◽  
Mao Ye ◽  
Peicheng Xu ◽  
Guolin Lu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Graft Copolymer ◽  
Self Assembly ◽  
Raft Polymerization ◽  
Drug Loading ◽  
Aqueous Media ◽  
Amphiphilic Polymer ◽  
Amphiphilic Graft Copolymer

This article reports the synthesis of a PAA-g-PLA amphiphilic polymer by the combination of RAFT polymerization and organocatalytic ROP, which could self-assemble into spheres in aqueous media for sustained release of doxorubicin.

scholarly journals Synthesis of an amphiphilic graft copolymer bearing a hydrophilic poly(acrylate acid) backbone for drug delivery of methotrexate

RSC Advances ◽  
2017 ◽  
Vol 7 (86) ◽  
pp. 54562-54569 ◽  
Author(s):  
Wei Wang ◽  
Xin Zhou ◽  
Min Wei ◽  
Zude Liu ◽  
Guolin Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Graft Copolymer ◽  
Aqueous Media ◽  
Graft Polymer ◽  
Amphiphilic Graft Copolymer ◽  
Large Compound

This article reports the synthesis of a PAA-g-PLA amphiphilic graft polymer, which could self-assemble into large compound micelles in aqueous media for sustained release of MTX.

scholarly journals Development of In Situ Self-Assembly Nanoparticles to Encapsulate Lopinavir and Ritonavir for Long-Acting Subcutaneous Injection

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 904
Author(s):  
Irin Tanaudommongkon ◽  
Asama Tanaudommongkon ◽  
Xiaowei Dong
Keyword(s):  
Sustained Release ◽  
Trough Concentration ◽  
Self Assembly ◽  
Subcutaneous Injection ◽  
Drug Loading ◽  
Entrapment Efficiency ◽  
Long Acting

Most antiretroviral medications for human immunodeficiency virus treatment and prevention require high levels of patient adherence, such that medications need to be administered daily without missing doses. Here, a long-acting subcutaneous injection of lopinavir (LPV) in combination with ritonavir (RTV) using in situ self-assembly nanoparticles (ISNPs) was developed to potentially overcome adherence barriers. The ISNP approach can improve the pharmacokinetic profiles of the drugs. The ISNPs were characterized in terms of particle size, drug entrapment efficiency, drug loading, in vitro release study, and in vivo pharmacokinetic study. LPV/RTV ISNPs were 167.8 nm in size, with a polydispersity index of less than 0.35. The entrapment efficiency was over 98% for both LPV and RTV, with drug loadings of 25% LPV and 6.3% RTV. A slow release rate of LPV was observed at about 20% on day 5, followed by a sustained release beyond 14 days. RTV released faster than LPV in the first 5 days and slower than LPV thereafter. LPV trough concentration remained above 160 ng/mL and RTV trough concentration was above 50 ng/mL after 6 days with one subcutaneous injection. Overall, the ISNP-based LPV/RTV injection showed sustained release profiles in both in vitro and in vivo studies.

scholarly journals Synthesis of amphiphilic copolymers based on acrylic acid, fluoroalkyl acrylates and n-butyl acrylate in organic, aqueous–organic, and aqueous media via RAFT polymerization

RSC Advances ◽  
2017 ◽  
Vol 7 (39) ◽  
pp. 24522-24536 ◽  
Author(s):  
N. S. Serkhacheva ◽  
O. I. Smirnov ◽  
A. V. Tolkachev ◽  
N. I. Prokopov ◽  
A. V. Plutalova ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Polyacrylic Acid ◽  
Self Assembly ◽  
Butyl Acrylate ◽  
Raft Polymerization ◽  
Aqueous Media ◽  
Amphiphilic Copolymers

Hydrophilic and amphiphilic polymeric trithiocarbonates based on polyacrylic acid are able to provide polymerization-induced self-assembly in copolymerization of butyl and fluoroalkyl acrylates.

scholarly journals β-Cyclodextrin-Poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors

2020 ◽  
Author(s):  
Sauradip Chaudhuri ◽  
Martha Fowler ◽  
Afroz S. Mohammad ◽  
Wenqui Zhang ◽  
Cassandra Baker ◽  
...  
Keyword(s):  
Self Assembly ◽  
Network Architecture ◽  
Hydrophobic Interactions ◽  
Drug Loading ◽  
Aqueous Media ◽  
Nile Red ◽  
High Loading ◽  
Hydrophobic Core ◽  
Amino Ester ◽  
Critical Determinant

<p> Here, we describe a simple, efficient formulation of a novel library of β-cyclodextrin-poly (β-amino ester) networks (CDN) to achieve this goal. We observed that network architecture was a critical determinant of CDN encapsulation of candidate molecules, with a more hydrophobic core enabling effective self-assembly and a PEGylated surface enabling high loading (up to ~30% w/w), effective self assembly of the nanoparticle, and slow release of drug into aqueous media (24 days) for the model <i>HDACi</i> panobinostat. Optimized CDN nanoparticles were taken up by GL261 cells in culture, and released panobinostat was confirmed to be bioactive. Pharmacokinetic analyses demonstrated that panobinostat was delivered to the brainstem, cerebellum, and upper spinal cord following intrathecal administration via cisterna magna injection in healthy mice. We next constructed a library of CDNs to encapsulate various small, hydrophobic, ionizable molecules (panobinostat, quisinostat, dacinostat, givinostat, and bortezomib, camptothecin, nile red, and cytarabine), which yielded important insights into the structural requirements for effective drug loading and CDN self-assembly. Taken in sum, these studies present a novel nanocarrier platform for encapsulation of <i>HDACi</i> via both ionic and hydrophobic interactions, which is an important step toward better treatment of disease via <i>HDACi</i> therapy.</p>

An Hg2+-selective chemosensor based on the self-assembly of a novel amphiphilic block copolymer bearing rhodamine 6G derivative moieties in purely aqueous media

2015 ◽  
Vol 7 (6) ◽  
pp. 2738-2746 ◽  
Author(s):  
Zhao Wang ◽  
Zhongkui Yang ◽  
Tao Gao ◽  
Jingwen He ◽  
Laijiang Gong ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Rhodamine 6G ◽  
Raft Polymerization ◽  
Aqueous Media ◽  
The Self ◽  
Amphiphilic Block Copolymer ◽  
Fluorescent Chemosensor

An amphiphilic block copolymer-based colorimetric and fluorescent chemosensor for Hg2+was prepared, which was synthesized by sequential RAFT polymerization of NIPAM and R6GDM (a novel Hg2+-sensitive rhodamine monomer).

PEG-conjugated pyrrole-based polymers: one-pot multicomponent synthesis and self-assembly into soft nanoparticles for drug delivery

2019 ◽  
Vol 55 (66) ◽  
pp. 9829-9832 ◽  
Author(s):  
Alexandre Moquin ◽  
Ramez Hanna ◽  
Tongyue Liang ◽  
Huseyin Erguven ◽  
Evan Rizzel Gran ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Self Assembly ◽  
Drug Loading ◽  
Easy Access ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Soft Nanoparticles

A simple one-pot methodology provides easy access to amphiphilic PEG–pyrrole backbone polymers, which self-assemble into soft nanoparticles enabling efficient drug loading/sustained release and can be detected inside cells.

Amphiphilic Graft Copolymer Nanospheres: From Colloidal Self-Assembly to CO2 Capture Membranes

2016 ◽  
Vol 8 (14) ◽  
pp. 9454-9461 ◽  
Author(s):  
Harim Jeon ◽  
Dong Jun Kim ◽  
Min Su Park ◽  
Du Yeol Ryu ◽  
Jong Hak Kim
Keyword(s):  
Graft Copolymer ◽  
Co2 Capture ◽  
Self Assembly ◽  
Amphiphilic Graft Copolymer

scholarly journals β-Cyclodextrin-Poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors

2020 ◽  
Author(s):  
Sauradip Chaudhuri ◽  
Martha Fowler ◽  
Afroz S. Mohammad ◽  
Wenqui Zhang ◽  
Cassandra Baker ◽  
...  
Keyword(s):  
Self Assembly ◽  
Network Architecture ◽  
Hydrophobic Interactions ◽  
Drug Loading ◽  
Aqueous Media ◽  
Nile Red ◽  
High Loading ◽  
Hydrophobic Core ◽  
Amino Ester ◽  
Critical Determinant

<p> Here, we describe a simple, efficient formulation of a novel library of β-cyclodextrin-poly (β-amino ester) networks (CDN) to achieve this goal. We observed that network architecture was a critical determinant of CDN encapsulation of candidate molecules, with a more hydrophobic core enabling effective self-assembly and a PEGylated surface enabling high loading (up to ~30% w/w), effective self assembly of the nanoparticle, and slow release of drug into aqueous media (24 days) for the model <i>HDACi</i> panobinostat. Optimized CDN nanoparticles were taken up by GL261 cells in culture, and released panobinostat was confirmed to be bioactive. Pharmacokinetic analyses demonstrated that panobinostat was delivered to the brainstem, cerebellum, and upper spinal cord following intrathecal administration via cisterna magna injection in healthy mice. We next constructed a library of CDNs to encapsulate various small, hydrophobic, ionizable molecules (panobinostat, quisinostat, dacinostat, givinostat, and bortezomib, camptothecin, nile red, and cytarabine), which yielded important insights into the structural requirements for effective drug loading and CDN self-assembly. Taken in sum, these studies present a novel nanocarrier platform for encapsulation of <i>HDACi</i> via both ionic and hydrophobic interactions, which is an important step toward better treatment of disease via <i>HDACi</i> therapy.</p>

Self-Assembly of Amphiphilic Graft Copolymer with Poly(acrylic Acid) Backbone and N-Octylphenyl Poly(oxyethylene) Side Chains in Water

2011 ◽  
Vol 233-235 ◽  
pp. 2138-2144 ◽  
Author(s):  
Fang Ping Wang ◽  
Xin Zhen Du ◽  
Hu Po Mu ◽  
Dong Xia Zhang ◽  
Yun Jun Ma
Keyword(s):  
Electron Microscopy ◽  
Graft Copolymer ◽  
Self Assembly ◽  
Inorganic Salt ◽  
The Self ◽  
Fluorescence Technique ◽  
Preparation Methods ◽  
Amphiphilic Graft Copolymer ◽  
Ph Values ◽  
Transmission Electron

The self-assembly of the amphiphilic graft copolymer AA-C8PhEO10Ac in water was investigated by fluorescence technique using 8-anilino-1-naphthalene sulfonate(ANS) as a probe and transmission electron microscopy (TEM), the effects of inorganic salt , copolymer concentration and pH on the micellar size and structures of AA-C8PhEO10Ac were discussed. It was found that the micelle morphologies and sizes were related with the micellar preparation methods. The sizes of micelles increased with the addition of NaCl and decreased at high pH values.

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