pH-Sensitive amphiphilic block-copolymers for transport and controlled release of oxygen

2017 ◽  
Vol 8 (30) ◽  
pp. 4322-4326 ◽  
Author(s):  
Y. Patil ◽  
S. Almahdali ◽  
K. B. Vu ◽  
G. Zapsas ◽  
N. Hadjichristidis ◽  
...  
Keyword(s):  
Controlled Release ◽  
Block Copolymers ◽  
Oxygen Transport ◽  
Ph Sensitive ◽  
Amphiphilic Block Copolymers ◽  
Polymer Dispersions

The synthesis of a library of amphiphilic-fluorous block-copolymers is described, and the capacity of these copolymers for oxygen transport in water is systematically investigated. The release of O2 from some of the polymer dispersions could be triggered simply by changing the pH of the solution.

Synthesis of new pH-sensitive amphiphilic block copolymers and study for the micellization using a fluorescence probe

2008 ◽  
Vol 16 (2) ◽  
pp. 169-177 ◽  
Author(s):  
Kyung Min Kim ◽  
Song-yee Choi ◽  
Hee Jeong Jeon ◽  
Jae Yeol Lee ◽  
Dong Joon Choo ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Fluorescence Probe ◽  
Ph Sensitive ◽  
Amphiphilic Block Copolymers

Hypoxia-responsive micelles self-assembled from amphiphilic block copolymers for the controlled release of anticancer drugs

2019 ◽  
Vol 7 (2) ◽  
pp. 286-295 ◽  
Author(s):  
Yinlu Deng ◽  
Hua Yuan ◽  
Weizhong Yuan
Keyword(s):  
Controlled Release ◽  
Block Copolymers ◽  
Anticancer Drugs ◽  
Amphiphilic Block Copolymers ◽  
Hypoxic Conditions ◽  
Copolymer Micelles ◽  
Self Assembled

Hypoxia-responsive PEG-b-P(MAA-co-NIMA) copolymer micelles expanded under hypoxic conditions and achieved the controlled release of anticancer DOX molecules.

Novel Ferrocenyl-Terminated Linear–Dendritic Amphiphilic Block Copolymers: Synthesis, Redox-Controlled Reversible Self-Assembly, and Oxidation-Controlled Release

Langmuir ◽  
2014 ◽  
Vol 30 (29) ◽  
pp. 8707-8716 ◽  
Author(s):  
Xueyi Chang ◽  
Renfeng Dong ◽  
Biye Ren ◽  
Zhiyu Cheng ◽  
Jun Peng ◽  
...  
Keyword(s):  
Controlled Release ◽  
Block Copolymers ◽  
Self Assembly ◽  
Amphiphilic Block Copolymers

Micellization in pH-sensitive amphiphilic block copolymers in aqueous media and the formation of metal nanoparticles

2005 ◽  
Vol 128 ◽  
pp. 129 ◽  
Author(s):  
Maria Vamvakaki ◽  
Lampros Papoutsakis ◽  
Vasilios Katsamanis ◽  
Theodora Afchoudia ◽  
Panagiota G. Fragouli ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Metal Nanoparticles ◽  
Aqueous Media ◽  
Ph Sensitive ◽  
Amphiphilic Block Copolymers

Transforming Frozen Self-Assemblies of Amphiphilic Block Copolymers Into Dynamic pH-Sensitive Micelles

2012 ◽  
Vol 33 (9) ◽  
pp. 753-759 ◽  
Author(s):  
Fabien Dutertre ◽  
Olivier Boyron ◽  
Bernadette Charleux ◽  
Christophe Chassenieux ◽  
Olivier Colombani
Keyword(s):  
Block Copolymers ◽  
Ph Sensitive ◽  
Amphiphilic Block Copolymers

scholarly journals A New Approach to Developing Long-Acting Injectable Formulations of Anti-HIV Drugs: Poly(Ethylene Phosphoric Acid) Block Copolymers Increase the Efficiency of Tenofovir against HIV-1 in MT-4 Cells

2020 ◽  
Vol 22 (1) ◽  
pp. 340
Author(s):  
Ilya Nifant’ev ◽  
Andrei Siniavin ◽  
Eduard Karamov ◽  
Maxim Kosarev ◽  
Sergey Kovalchuk ◽  
...  
Keyword(s):  
Controlled Release ◽  
Block Copolymers ◽  
Phosphoric Acid ◽  
Hiv Infection ◽  
Targeted Delivery ◽  
Release Formulation ◽  
Poly Ethylene ◽  
Long Acting ◽  
Hiv Drugs ◽  
Anti Hiv

Despite the world’s combined efforts, human immunodeficiency virus (HIV), the causative agent of AIDS, remains one of the world’s most serious public health challenges. High genetic variability of HIV complicates the development of anti-HIV vaccine, and there is an actual clinical need for increasing the efficiency of anti-HIV drugs in terms of targeted delivery and controlled release. Tenofovir (TFV), a nucleotide-analog reverse transcriptase inhibitor, has gained wide acceptance as a drug for pre-exposure prophylaxis or treatment of HIV infection. In our study, we explored the potential of tenofovir disoproxil (TFD) adducts with block copolymers of poly(ethylene glycol) monomethyl ether and poly(ethylene phosphoric acid) (mPEG-b-PEPA) as candidates for developing a long-acting/controlled-release formulation of TFV. Two types of mPEG-b-PEPA with numbers of ethylene phosphoric acid (EPA) fragments of 13 and 49 were synthesized by catalytic ring-opening polymerization, and used for preparing four types of adducts with TFD. Antiviral activity of [mPEG-b-PEPA]TFD or tenofovir disoproxil fumarate (TDF) was evaluated using the model of experimental HIV infection in vitro (MT-4/HIV-1IIIB). Judging by the values of the selectivity index (SI), TFD exhibited an up to 14-fold higher anti-HIV activity in the form of mPEG-b-PEPA adducts, thus demonstrating significant promise for further development of long-acting/controlled-release injectable TFV formulations.

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