In situ synthesis of a self-assembled AB/B blend of poly(ethylene glycol)-b-polystyrene/polystyrene by dispersion RAFT polymerization

2017 ◽  
Vol 8 (14) ◽  
pp. 2173-2181 ◽  
Author(s):  
Bing Yuan ◽  
Xin He ◽  
Yaqing Qu ◽  
Chengqiang Gao ◽  
Erika Eiser ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Raft Polymerization ◽  
In Situ Synthesis ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene

A diblock-copolymer/homopolymer self-assembled blend was synthesized through dispersion RAFT polymerization, and its morphology changed with a decreasing ratio of diblock-copolymer/homopolymer.

The in situ formation of nanoparticles via RAFT polymerization-induced self-assembly in a continuous tubular reactor

2017 ◽  
Vol 8 (9) ◽  
pp. 1495-1506 ◽  
Author(s):  
Jinying Peng ◽  
Chun Tian ◽  
Lifen Zhang ◽  
Zhenping Cheng ◽  
Xiulin Zhu
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Self Assembly ◽  
Raft Polymerization ◽  
Tubular Reactor ◽  
Poly Ethylene Glycol ◽  
In Situ Formation ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Amphiphilic poly(poly(ethylene glycol)methyl ether methacrylate)-b-poly(methyl methacrylate) (PPEGMA-b-PMMA) diblock copolymer nanoparticles were successfully synthesized via polymerization-induced self-assembly (PISA) at 70 °C in a continuous tubular reactor.

In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly(ethylene glycol)-b-polycaprolactone diblock copolymer

Biomaterials ◽  
2011 ◽  
Vol 32 (20) ◽  
pp. 4556-4564 ◽  
Author(s):  
Yun Mi Kang ◽  
Gyeong Hae Kim ◽  
Jae Il Kim ◽  
Da Yeon Kim ◽  
Bit Na Lee ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Poly Ethylene Glycol ◽  
In Vivo Efficacy ◽  
In Situ Forming ◽  
Poly Ethylene

scholarly journals In situ synthesis of biomolecule encapsulated gold-cross-linked poly(ethylene glycol) nanocomposite as biosensing platform: A model study

2010 ◽  
Vol 79 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Dilek Odaci ◽  
Muhammet U. Kahveci ◽  
Elif L. Sahkulubey ◽  
Caglar Ozdemir ◽  
Tamer Uyar ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
In Situ Synthesis ◽  
Poly Ethylene Glycol ◽  
Model Study ◽  
Poly Ethylene

scholarly journals One-Pot, In-Situ Synthesis of 8-Armed Poly(Ethylene Glycol)-Coated Ag Nanoclusters as a Fluorescent Sensor for Selective Detection of Cu2+

Biosensors ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 131 ◽  
Author(s):  
Xiaoyuan Zhang ◽  
Guanghua Zhang ◽  
Gang Wei ◽  
Zhiqiang Su
Keyword(s):  
Quantum Dots ◽  
Ethylene Glycol ◽  
Fluorescent Sensor ◽  
In Situ Synthesis ◽  
Selective Detection ◽  
Poly Ethylene Glycol ◽  
One Pot ◽  
Detection Range ◽  
Poly Ethylene

Fluorescent nanomaterials, such as quantum dots, have developed rapidly in recent years and have been significantly developed. Herein, we demonstrate a facile, one-pot, and in-situ synthesis strategy to obtain fluorescent silver nanoclusters (AgNCs) coated with eight-armed poly (ethylene glycol) polymers (8PEG-AgNCs) via a direct gel-mediated process. During the synthesis, ammonium (NH3) served as the crosslinker for the gel formation via a amine-type Michael addition reaction. This hydrogel can be used as a template to synthesize AgNCs using its volume-limiting effect. The in-situ generation of AgNCs takes place inside the nanocages of the formed gels, which guarantees the homogenous distribution of AgNCs in the gel matrix, as well as the efficient coating of PEG on the nanoclusters. After the degradation of gels, the released 8PEG-AgNCs nanohybrids showed strong blue fluorescence and exhibited long-term stability in aqueous solution for nearly one year. Results showed that the fabricated sensor revealed excellent fluorescent sensitivity for the selective detection of Cu2+ with a detection limit of 50 nM and a wide linear detection range of 5–100 μM. It is proposed that the greater cross-linking density leads to smaller gel pores and allows the synthesis of AgNCs with fluorescent properties. These results indicate that this novel hydrogel with certain biodegradation has the potential to be applied as a fluorescent sensor for catalytic synthesis, fluorescence tracing in cells, and fluorescence detection fields. Meanwhile, the novel design principle has a certain versatility to accelerate the development and application of other kinds of metal nanoclusters and quantum dots.

Self-assembled star-shaped chlorin-core poly(ɛ-caprolactone)–poly(ethylene glycol) diblock copolymer micelles for dual chemo-photodynamic therapies

Biomaterials ◽  
2008 ◽  
Vol 29 (26) ◽  
pp. 3599-3608 ◽  
Author(s):  
Cheng-Liang Peng ◽  
Ming-Jium Shieh ◽  
Ming-Hsien Tsai ◽  
Cheng-Chung Chang ◽  
Ping-Shan Lai
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Poly Ethylene Glycol ◽  
Copolymer Micelles ◽  
Self Assembled ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

FhuA deletion variant Δ1-159 overexpression in inclusion bodies and refolding with Polyethylene-Poly(ethylene glycol) diblock copolymer

2011 ◽  
Vol 77 (1) ◽  
pp. 75-79 ◽  
Author(s):  
Tamara Dworeck ◽  
Anne-Kathrin Petri ◽  
Noor Muhammad ◽  
Marco Fioroni ◽  
Ulrich Schwaneberg
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Inclusion Bodies ◽  
Poly Ethylene Glycol ◽  
Deletion Variant ◽  
Poly Ethylene
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