scholarly journals A broad scope of aliphatic polyesters prepared by elimination of small molecules from sustainable 1,3-dioxolan-4-ones

2017 ◽  
Vol 8 (19) ◽  
pp. 2990-2996 ◽  
Author(s):  
Stefan A. Cairns ◽  
Amelie Schultheiss ◽  
Michael P. Shaver
Keyword(s):  
Small Molecules ◽  
Renewable Resources ◽  
Aliphatic Polyesters ◽  
Broad Scope

We report a family of monomers that are built from renewable resources and use the elimination of small molecules to access aliphatic polyesters, circumventing challenging monomer syntheses to make these functionalism polymers.

New polymers from renewable resources: synthesis, characterization, and photodurability of aliphatic polyesters containing glycerol

2010 ◽  
Vol 150 ◽  
pp. 206-206 ◽  
Author(s):  
Annamaria Celli ◽  
Paola Marchese ◽  
Simone Sullalti ◽  
Corrado Berti ◽  
Sophie Commereuc ◽  
...  
Keyword(s):  
Renewable Resources ◽  
Aliphatic Polyesters

scholarly journals Iron-catalyzed hydrogenation and dehydrogenation reactions with relevance to reversible hydrogen storage applications

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Thomas Zell ◽  
Robert Langer
Keyword(s):  
Hydrogen Storage ◽  
Small Molecules ◽  
Renewable Resources ◽  
Carbonyl Compounds ◽  
Reverse Reaction ◽  
Hydrogen Release ◽  
Practical Reasons ◽  
Highly Active ◽  
Dehydrogenation Reactions ◽  
Catalyst Systems

AbstractToday’s energy concerns require the development of suitable solutions for the storage of energy from renewable resources. Although the chemical storage of energy using molecular hydrogen as energy carrier is one of the best options, this type of energy storage requires the conversion of hydrogen to liquid organic hydrogen careers (LOHCs) for practical reasons. This goal is challenging and highly desirable at the same time. In comparison to dihydrogen, hydrogen storage in LOHCs offers easier handling and minimum dangers involved in their production, storage, and reconversion. To achieve efficient processes based on LOHCs highly active catalyst systems are required which ideally are based on cheap and abundant metals such as iron. This review summarizes recent advances in ironcatalyzed hydrogenation and dehydrogenation reactions, with relevance to reversible hydrogen storage in small molecules. It entails the dehydrogenation reactions of formic acid and methanol water mixtures, the reverse reaction, the hydrogenation of CO2, dehydrogenation of alcohols, and the hydrogenation of different carbonyl compounds as the formal reverse reaction, as well as hydrogenation and dehydrogenation reactions of N-heterocyclic compounds and hydrogen release reactions from amino boranes.

Fully Biobased Unsaturated Aliphatic Polyesters from Renewable Resources: Enzymatic Synthesis, Characterization, and Properties

2014 ◽  
Vol 215 (22) ◽  
pp. 2185-2197 ◽  
Author(s):  
Yi Jiang ◽  
Gert O. R. Alberda van Ekenstein ◽  
Albert J. J. Woortman ◽  
Katja Loos
Keyword(s):  
Renewable Resources ◽  
Enzymatic Synthesis ◽  
Aliphatic Polyesters

scholarly journals Design and Scalable Synthesis of Novel N-Alkyl-Hydroxylamine Reagents for the Direct, Fe-Catalyzed Installation of Medicinally Relevant Amines

2020 ◽  
Author(s):  
Eric Falk ◽  
Szabolcs Makai ◽  
Tristan Delcaillau ◽  
Laura Gürtler ◽  
Bill Morandi
Keyword(s):  
Small Molecules ◽  
Functional Group ◽  
Direct Synthesis ◽  
Biologically Active ◽  
Iron Catalysis ◽  
Broad Scope ◽  
Amine Groups ◽  
Scalable Synthesis

<p>Secondary and tertiary alkylamines are privileged substance classes which are often found in pharmaceuticals and other biologically active small molecules. Herein, we report their direct synthesis from alkenes through an aminative difunctionalization reaction enabled by iron catalysis. A family of nine novel hydroxylamine-derived aminating reagents was designed for the installation of several medicinally relevant amine groups, such as methylamine, morpholine and piperazine, through the aminochlorination of alkenes. The methodology displays an excellent functional group tolerance, and a broad scope of alkenes was converted to the corresponding products, including several drug-like molecules. Besides aminochlorination, the installation of other functionalities through aminoazidation, aminohydroxylation and even intramolecular carboamination reactions, is demonstrated, further highlighting the broad potential of these new reagents for the discovery of novel amination reactions.</p>

scholarly journals Design and Scalable Synthesis of Novel N-Alkyl-Hydroxylamine Reagents for the Direct, Fe-Catalyzed Installation of Medicinally Relevant Amines

2020 ◽  
Author(s):  
Eric Falk ◽  
Szabolcs Makai ◽  
Tristan Delcaillau ◽  
Laura Gürtler ◽  
Bill Morandi
Keyword(s):  
Small Molecules ◽  
Functional Group ◽  
Direct Synthesis ◽  
Biologically Active ◽  
Iron Catalysis ◽  
Broad Scope ◽  
Amine Groups ◽  
Scalable Synthesis

<p>Secondary and tertiary alkylamines are privileged substance classes which are often found in pharmaceuticals and other biologically active small molecules. Herein, we report their direct synthesis from alkenes through an aminative difunctionalization reaction enabled by iron catalysis. A family of nine novel hydroxylamine-derived aminating reagents was designed for the installation of several medicinally relevant amine groups, such as methylamine, morpholine and piperazine, through the aminochlorination of alkenes. The methodology displays an excellent functional group tolerance, and a broad scope of alkenes was converted to the corresponding products, including several drug-like molecules. Besides aminochlorination, the installation of other functionalities through aminoazidation, aminohydroxylation and even intramolecular carboamination reactions, is demonstrated, further highlighting the broad potential of these new reagents for the discovery of novel amination reactions.</p>

Environmentally benign synthesis of saturated and unsaturated aliphatic polyesters via enzymatic polymerization of biobased monomers derived from renewable resources

2015 ◽  
Vol 6 (30) ◽  
pp. 5451-5463 ◽  
Author(s):  
Yi Jiang ◽  
Albert J. J. Woortman ◽  
Gert O. R. Alberda van Ekenstein ◽  
Katja Loos
Keyword(s):  
Renewable Resources ◽  
Environmentally Benign ◽  
Enzymatic Polymerization ◽  
Structure Property ◽  
Aliphatic Polyesters ◽  
Structure Property Relationships ◽  
Benign Synthesis

Biobased saturated aliphatic polyesters and photo-curable unsaturated aliphatic polyesters are enzymatically polymerized, and their structure–property relationships are systematically studied.

scholarly journals Enzyme-Catalyzed Synthesis of Unsaturated Aliphatic Polyesters Based on Green Monomers from Renewable Resources

Biomolecules ◽  
2013 ◽  
Vol 3 (4) ◽  
pp. 461-480 ◽  
Author(s):  
Yi Jiang ◽  
Albert Woortman ◽  
Gert van Ekenstein ◽  
Katja Loos
Keyword(s):  
Renewable Resources ◽  
Aliphatic Polyesters

Gap junctions in the prothoracic glands of the tobacco hornworm, Manduca sexta

1992 ◽  
Vol 50 (1) ◽  
pp. 706-707
Author(s):  
Ji-da Dai ◽  
M. Joseph Costello ◽  
Lawrence I. Gilbert
Keyword(s):  
Gap Junctions ◽  
Small Molecules ◽  
Manduca Sexta ◽  
Freeze Fracture ◽  
Cell Communication ◽  
Cellular Level ◽  
Thin Sections ◽  
Prothoracic Glands ◽  
Polyhydroxylated Steroids ◽  
Stimulation Of

Insect molting and metamorphosis are elicited by a class of polyhydroxylated steroids, ecdysteroids, that originate in the prothoracic glands (PGs). Prothoracicotropic hormone stimulation of steroidogenesis by the PGs at the cellular level involves both calcium and cAMP. Cell-to-cell communication mediated by gap junctions may play a key role in regulating signal transduction by controlling the transmission of small molecules and ions between adjacent cells. This is the first report of gap junctions in the PGs, the evidence obtained by means of SEM, thin sections and freeze-fracture replicas.

Fusion and Fission Processes in Exocytosis: Possible Roles for Synexin and Osmotic Lysis in the Two Events

1980 ◽  
Vol 38 ◽  
pp. 594-597
Author(s):  
H.B. Pollard ◽  
C.E. Creutz ◽  
C.J. Pazoles ◽  
J.H. Scott
Keyword(s):  
Small Molecules ◽  
Chromaffin Cells ◽  
Adrenal Glands ◽  
General Concept ◽  
Extracellular Calcium ◽  
Large Protein ◽  
Granule Membrane ◽  
Osmotic Lysis ◽  
Per Se ◽  
Chemical Evidence

Exocytosis is a general concept describing secretion of enzymes, hormones and transmitters that are otherwise sequestered in intracellular granules. Chemical evidence for this concept was first gathered from studies on chromaffin cells in perfused adrenal glands, in which it was found that granule contents, including both large protein and small molecules such as adrenaline and ATP, were released together while the granule membrane was retained in the cell. A number of exhaustive reviews of this early work have been published and are summarized in Reference 1. The critical experiments demonstrating the importance of extracellular calcium for exocytosis per se were also first performed in this system (2,3), further indicating the substantial service given by chromaffin cells to those interested in secretory phenomena over the years.

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