(+)- and (−)-Ascomlactone A: a pair of novel dimeric polyketides from a mangrove endophytic fungus Ascomycota sp. SK2YWS-L

2017 ◽  
Vol 15 (48) ◽  
pp. 10276-10280 ◽  
Author(s):  
Zhaoming Liu ◽  
Senhua Chen ◽  
Pei Qiu ◽  
Chunbing Tan ◽  
Yuhua Long ◽  
...  

Two novel enantiomeric polyketide dimers were obtained from a mangrove endophytic fungus Ascomycota sp. with potential α-glucosidase inhibitory activities.

Marine Drugs ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. 88 ◽  
Author(s):  
Zhihui Wu ◽  
Jiaqing Chen ◽  
Xiaolin Zhang ◽  
Zelin Chen ◽  
Tong Li ◽  
...  

Four new isocoumarin derivatives, botryospyrones A (1), B (2), C (3), and D (4), and a new natural tryptamine, (3aS, 8aS)-1-acetyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo [2,3b] indol-3a-ol (5), were isolated from a marine mangrove endophytic fungus Botryosphaeria ramosa L29, obtained from the leaf of Myoporum bontioides. Their structures were elucidated using spectroscopic analysis. The absolute configurations of compounds 3, 4, and 5 were determined by comparison of their circular dichroism (CD) spectra with the calculated data. The inhibitory activities of compound 1 on Fusarium oxysporum, of compounds 2 and 3 on F. oxysporum and Fusarium graminearum, and of compound 5 on F. oxysporum, Penicillium italicum, and F. graminearum were higher than those of triadimefon, widely used as an agricultural fungicide. Compound 5 was produced after using the strategy we called “using inhibitory stress from components of the host” (UISCH), wherein (2R, 3R)-3, 5, 7-trihydroxyflavanone 3-acetate, a component of M. bontioides with weak growth inhibitory activity towards B. ramosa L29, was introduced into the culture medium.


2020 ◽  
Vol 104 ◽  
pp. 104300
Author(s):  
Zhibo Hu ◽  
Zhihui Wu ◽  
Qinhua Su ◽  
Mingzhe Li ◽  
Shanshan Wu ◽  
...  

2020 ◽  
Vol 61 (48) ◽  
pp. 152578 ◽  
Author(s):  
Yan Chen ◽  
Wencong Yang ◽  
Ge Zou ◽  
Zhangyuan Yan ◽  
Pei Qiu ◽  
...  

2013 ◽  
Vol 27 (20) ◽  
pp. 1902-1905 ◽  
Author(s):  
Jianxiang Yang ◽  
Riming Huang ◽  
Sheng Xiang Qiu ◽  
Zhigang She ◽  
Yongcheng Lin

2014 ◽  
Vol 10 ◽  
pp. 2677-2682 ◽  
Author(s):  
Zhi Kai Guo ◽  
Rong Wang ◽  
Wei Huang ◽  
Xiao Nian Li ◽  
Rong Jiang ◽  
...  

An unusual C18 norditerpenoid, aspergiloid I (1), was isolated from the culture broth of Aspergillus sp. YXf3, an endophytic fungus derived from Ginkgo biloba. Its structure was unambiguously established by analysis of HRMS–ESI and spectroscopic data, and the absolute configuration was determined by low-temperature (100 K) single crystal X-ray diffraction with Cu Kα radiation. This compound is structurally characterized by a new carbon skeleton with an unprecedented 6/5/6 tricyclic ring system bearing an α,β-unsaturated spirolactone moiety in ring B, and represents a new subclass of norditerpenoid, the skeleton of which is named aspergilane. The hypothetical biosynthetic pathway for 1 was also proposed. The cytotoxic, antimicrobial, anti-oxidant and enzyme inhibitory activities of 1 were evaluated.


2013 ◽  
Vol 27 (20) ◽  
pp. 1882-1887 ◽  
Author(s):  
Chunmei Deng ◽  
Caihuan Huang ◽  
Qili Wu ◽  
Jiyan Pang ◽  
Yongcheng Lin

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