Construction of tetrahydropyranoquinoline derivativesviaan asymmetric organocatalytic aza-Michael-IED/HAD cascade reaction

2017 ◽  
Vol 15 (45) ◽  
pp. 9630-9637 ◽  
Author(s):  
Lu Dai ◽  
Yuxuan Hou ◽  
Lvye Zhang ◽  
Zhangtao Chen ◽  
Xiaofei Zeng ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Highly Efficient

A highly efficient organocatalytic asymmetric aza-Michael-IED/HAD cascade reaction of (E)-ethyl 4-(2-(4-methylphenylsulfonamido)phenyl)-2-oxobut-3-enoate and enals is reported.

New efficient synthesis of benzofuro[2,3-b]pyrroles utilizing a reactive nitrilium trapping approach by an acid-promoted cascade addition/cyclization sequence

2020 ◽  
Vol 44 (9) ◽  
pp. 3632-3636
Author(s):  
Sandip Gangadhar Balwe ◽  
Yeon Tae Jeong
Keyword(s):  
Cascade Reaction ◽  
Efficient Synthesis ◽  
One Pot ◽  
Highly Efficient

The first p-TSA·H2O-catalyzed highly efficient one-pot cascade reaction for the synthesis of novel fused tricyclic benzofuro[2,3-b]pyrroles has been discovered.

scholarly journals A Responsive “Nano String Light” for Highly Efficient mRNA Imaging in Living Cells via Accelerated DNA Cascade Reaction

ACS Nano ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 263-271 ◽  
Author(s):  
Kewei Ren ◽  
Yifan Xu ◽  
Ying Liu ◽  
Min Yang ◽  
Huangxian Ju
Keyword(s):  
Living Cells ◽  
Cascade Reaction ◽  
Highly Efficient

Copper(II)-Promoted Oxidation/[3+2]Cycloaddition/Aromatization Cascade: Efficient Synthesis of Tetrasubstituted NH-Pyrrole from Chalcones and Iminodiacetates

Synlett ◽  
2019 ◽  
Vol 30 (12) ◽  
pp. 1442-1446 ◽  
Author(s):  
Zhang-qi Lin ◽  
Chao-dong Li ◽  
Zi-chun Zhou ◽  
Shuai Xue ◽  
Jian-rong Gao ◽  
...  
Keyword(s):  
Efficient Method ◽  
Cascade Reaction ◽  
Oxidative Cyclization ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Highly Efficient ◽  
Wide Range ◽  
Reaction Proceeds

A simple and highly efficient method for the preparation of tetrasubstituted NH-pyrrole from a wide range of chalcones and diethyl iminodiacetates via a Cu(OAc)2-promoted oxidation/[3+2]cycloaddition/aromatization cascade reaction has been developed. This reaction proceeds through dehydrogenations, deamination, and oxidative cyclization, affording the corresponding products in good to excellent yields. This convenient methodology for constructing tetrasubstituted NH-pyrroles has several advantages over existing methods, such as the use of easily accessible chalcones and readily available diethyl iminodiacetates, and mild reaction conditions. A wide range of substrates are tolerated.

A highly efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride leading to primary arylamines

2017 ◽  
Vol 41 (6) ◽  
pp. 315-320 ◽  
Author(s):  
Xue Huang ◽  
Ruian Xiao ◽  
Chongren You ◽  
Tao Yan ◽  
Mingzhong Cai
Keyword(s):  
Copper Complex ◽  
Cascade Reaction ◽  
Highly Efficient ◽  
Aryl Iodides ◽  
Reaction Solution ◽  
Simple Filtration ◽  
Mcm 41

A highly efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride was achieved in DMF in the presence of 10 mol% of an MCM-41-immobilised L-proline-copper(I) complex (MCM-41-L-proline-CuI) with Cs2CO3 as base, yielding a variety of primary arylamines in good to excellent yields. The new heterogeneous copper complex can be easily prepared from commercially readily available and inexpensive reagents, recovered by a simple filtration of the reaction solution and used at least seven more times without any decrease in activity.

An efficient synthesis of oxazolines via a cascade reaction between azaoxyallyl cations and 1,2-benzisoxazoles

2019 ◽  
Vol 17 (32) ◽  
pp. 7526-7530 ◽  
Author(s):  
Li Sun ◽  
Yi Liu ◽  
Yankai Wang ◽  
Yuanyuan Li ◽  
Zhiwen Liu ◽  
...  
Keyword(s):  
Cycloaddition Reaction ◽  
Cascade Reaction ◽  
Efficient Synthesis ◽  
Mild Conditions ◽  
Highly Efficient

A highly efficient 3 + 2 cycloaddition reaction with azaoxyallyl cation C–O terminals under mild conditions has been developed.

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