scholarly journals 25 years and still going strong: 2′-O-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science

2017 ◽  
Vol 15 (46) ◽  
pp. 9760-9774 ◽  
Author(s):  
Patrick J. Hrdlicka ◽  
Saswata Karmakar
Keyword(s):  
Molecular Biology ◽  
Materials Science ◽  
Building Blocks ◽  
Biophysical Properties ◽  
The Past ◽  
Wide Range

This review highlights the synthesis, biophysical properties, and wide range of applications of oligonucleotides modified with 2′-O-(pyren-1-yl)methyl-RNA monomers reported over the past 25 years.

Zeolates: A Coordination Chemistry View of Metal-Ligand Bonding in Intrazeolite MOCVD Type Precursors and Semiconductor Nanoclusters

1992 ◽  
Vol 277 ◽  
Author(s):  
Geoffrey A. Ozin ◽  
Carol L. Bowes ◽  
Mark R. Steele
Keyword(s):  
Self Assembly ◽  
Materials Science ◽  
Zeolite Y ◽  
Chemical Vapour ◽  
Internal Surface ◽  
Building Blocks ◽  
Structural Features ◽  
Organic Chemical ◽  
Wide Range ◽  
Shape Selective

ABSTRACTVarious MOCVD (metal-organic chemical vapour deposition) type precursors and their self-assembled semiconductor nanocluster products [1] have been investigated in zeolite Y hosts. From analysis of in situ observations (FTIR, UV-vis reflectance, Mössbauer, MAS-NMR) of the reaction sequences and structural features of the precursors and products (EXAFS and Rietveld refinement of powder XRD data) the zeolite is viewed as providing a macrospheroidal, multidendate coordination environment towards encapsulated guests. By thinking about the α- and β-cages of the zeolite Y host effectively as a zeolate ligand composed of interconnected aluminosilicate “crown ether-like” building blocks, the materials chemist is able to better understand and exploit the reactivity and coordination properties of the zeolite internal surface for the anchoring and self-assembly of a wide range of encapsulated guests. This approach helps with the design of synthetic strategies for creating novel guest-host inclusion compounds having possible applications in areas of materials science such as nonlinear optics, quantum electronics, and size/shape selective catalysis.

scholarly journals High-Throughput Computation of New Carbon Allotropes with Diverse Hybridization and Ultrahigh Hardness

Crystals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 783
Author(s):  
Mohammed Al-Fahdi ◽  
Alejandro Rodriguez ◽  
Tao Ouyang ◽  
Ming Hu
Keyword(s):  
High Throughput ◽  
Vickers Hardness ◽  
First Principles ◽  
Materials Science ◽  
Building Blocks ◽  
Packing Fraction ◽  
Unit Cell ◽  
Local Potential ◽  
Carbon Allotropes ◽  
Wide Range

The discovery of new carbon allotropes with different building blocks and crystal symmetries has long been of great interest to broad materials science fields. Herein, we report several hundred new carbon allotropes predicted by the state-of-the-art RG2 code and first-principles calculations. The types of new carbon allotropes that were identified in this work span pure sp2, hybrid sp2/sp3, and pure sp3 C–C bonding. All structures were globally optimized at the first-principles level. The thermodynamic stability of some selected carbon allotropes was further validated by computing their phonon dispersions. The predicted carbon allotropes possess a broad range of Vickers’ hardness. This wide range of Vickers’ hardness is explained in detail in terms of both atomic descriptors such as density, volume per atom, packing fraction, and local potential energy throughout the unit cell, and global descriptors such as elastic modulus, shear modulus, and bulk modulus, universal anisotropy, Pugh’s ratio, and Poisson’s ratio. For the first time, we found strong correlation between Vickers’ hardness and average local potentials in the unit cell. This work provides deep insight into the identification of novel carbon materials with high Vickers’ hardness for modern applications in which ultrahigh hardness is desired. Moreover, the local potential averaged over the entire unit cell of an atomic structure, an easy-to-evaluate atomic descriptor, could serve as a new atomic descriptor for efficient screening of the mechanical properties of unexplored structures in future high-throughput computing and artificial-intelligence-accelerated materials discovery methods.

Alkylation Reactions with Alkylsulfonium Salts

Synthesis ◽  
2021 ◽  
Author(s):  
Ze-Yu Tian ◽  
Yu Ma ◽  
Cheng-Pan Zhang
Keyword(s):  
Organic Molecules ◽  
High Efficiency ◽  
Building Blocks ◽  
Organometallic Reagents ◽  
The Past ◽  
Wide Range ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Alkylation Reactions

Application of alkylsulfonium salts as alkyl transfer reagents in organic synthesis has reemerged over the past years. Numerous heteroatom- and carbon-centered nucleophiles, alkenes, arenes, alkynes, organometallic reagents, and others were readily alkylated by alkylsulfonium salts under mild conditions. The reactions feature convenience, high efficiency, readily accessible and structurally diversified alkylation reagents, good functional group tolerance, and a wide range of substrate types, allowing for facile synthesis of various useful organic molecules from the commercially available building blocks. This review summarizes the alkylation reactions using either isolated or in situ formed alkylsulfonium salts via nucleophilic substitution, transition-metal-catalyzed reactions, and photoredox processes.

Advances in nano-biomaterials and their applications in biomedicine

2021 ◽  
Author(s):  
Yogita Patil-Sen
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Biomedical Applications ◽  
Materials Science ◽  
Disease Diagnosis ◽  
Biological Properties ◽  
The Past ◽  
Physico Chemical ◽  
Wide Range ◽  
Biomolecules Detection

Nano0technology has received considerable attention and interest over the past few decades in the field of biomedicine due to the wide range of applications it provides in disease diagnosis, drug design and delivery, biomolecules detection, tissue engineering and regenerative medicine. Ultra-small size and large surface area of nanomaterials prove to be greatly advantageous for their biomedical applications. Moreover, the physico-chemical and thus, the biological properties of nanomaterials can be manipulated depending on the application. However, stability, efficacy and toxicity of nanoparticles remain challenge for researchers working in this area. This mini-review highlights the recent advances of various types of nanoparticles in biomedicine and will be of great value to researchers in the field of materials science, chemistry, biology and medicine.

Molecular Biology

2016 ◽  
Author(s):  
Aysha Divan ◽  
Janice Royds
Keyword(s):  
Synthetic Biology ◽  
Personalized Medicine ◽  
Molecular Biology ◽  
Dna Fingerprinting ◽  
Genetically Modified Organisms ◽  
Building Blocks ◽  
New Drugs ◽  
Human History ◽  
Short Introduction ◽  
Wide Range

Molecular biology is the story of the molecules of life, their relationships, and how these interactions are controlled. Its applications are wide and growing; the power of molecular biology can now be harnessed to treat diseases, solve crimes, map human history, and produce genetically modified organisms and crops. Starting with the building blocks established by Darwin, Wallace, and Mendel, and the discovery of the structure of DNA in 1953, Molecular Biology: A Very Short Introduction considers the wide range of applications for molecular biology today, including the development of new drugs and DNA fingerprinting, and looks forward to two key areas of evolving research: personalized medicine and synthetic biology.

scholarly journals Transition Metal Catalyzed Azidation Reactions

Catalysts ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1173
Author(s):  
Roberto Sala ◽  
Camilla Loro ◽  
Francesca Foschi ◽  
Gianluigi Broggini
Keyword(s):  
Transition Metal ◽  
Materials Science ◽  
Building Blocks ◽  
Organic Azides ◽  
Wide Range ◽  
Carbon Carbon Bonds ◽  
Transition Metal Catalyzed ◽  
Vinyl Azides ◽  
Catalyzed Reactions ◽  
Metal Catalyzed

A wide range of methodologies for the preparation of organic azides has been reported in the literature for many decades, due to their interest as building blocks for different transformations and their applications in biology as well as in materials science. More recently, with the spread of the use of transition metal-catalyzed reactions, new perspectives have also materialized in azidation processes, especially concerning the azidation of C–H bonds and direct difunctionalization of multiple carbon-carbon bonds. In this review, special emphasis will be placed on reactions involving substrates bearing a leaving group, hydroazidation reactions and azidation reactions that proceed with the formation of more than one bond. Further reactions for the preparation of allyl and vinyl azides as well as for azidations involving the opening of a ring complete the classification of the material.

scholarly journals Blood Pressure Sensors: Materials, Fabrication Methods, Performance Evaluations and Future Perspectives

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4484
Author(s):  
Ahmed Al-Qatatsheh ◽  
Yosry Morsi ◽  
Ali Zavabeti ◽  
Ali Zolfagharian ◽  
Nisa Salim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Materials Science ◽  
Blood Pressure Monitoring ◽  
Wearable Sensors ◽  
Pressure Sensors ◽  
Functional Materials ◽  
Building Blocks ◽  
Clinical Use ◽  
Wide Range ◽  
Operational Life

Advancements in materials science and fabrication techniques have contributed to the significant growing attention to a wide variety of sensors for digital healthcare. While the progress in this area is tremendously impressive, few wearable sensors with the capability of real-time blood pressure monitoring are approved for clinical use. One of the key obstacles in the further development of wearable sensors for medical applications is the lack of comprehensive technical evaluation of sensor materials against the expected clinical performance. Here, we present an extensive review and critical analysis of various materials applied in the design and fabrication of wearable sensors. In our unique transdisciplinary approach, we studied the fundamentals of blood pressure and examined its measuring modalities while focusing on their clinical use and sensing principles to identify material functionalities. Then, we carefully reviewed various categories of functional materials utilized in sensor building blocks allowing for comparative analysis of the performance of a wide range of materials throughout the sensor operational-life cycle. Not only this provides essential data to enhance the materials’ properties and optimize their performance, but also, it highlights new perspectives and provides suggestions to develop the next generation pressure sensors for clinical use.

scholarly journals A review on the synthesis, surface modification and drug delivery of nanoparticles

2021 ◽  
Vol 8 (2) ◽  
pp. 032-045
Author(s):  
Md Dipu Ahmed ◽  
Kazi M Maraz ◽  
Shahirin Shahida ◽  
Tarannum Dihan ◽  
Ruhul A Khan
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
Materials Science ◽  
Health Sector ◽  
Review Article ◽  
Infrared Light ◽  
The Past ◽  
Inorganic Substances ◽  
Wide Range ◽  
Potential Impact

Over the past few years, the evolution of nanotechnology has extended into a wide range of applications. Nanotechnology has now become a multidisciplinary science that applies to electronics, materials science, biomedical engineering, microbiology, etc. Recently, nanotechnology is being used in biomedical and pharmaceutical science. Among them drug delivery is set to spread rapidly. Application of nanotechnology in health sector also created a potential impact such as in the fields of immunology, cardiology, endocrinology, ophthalmology, and oncology. Nanoparticles are unique because of their large surface area and it has the potential to change the properties of a bulk number of materials. The surface of nanoparticles can be modified with the help of various polymers, organic and inorganic substances according to the specific application and their use. Nanoparticles are also utilized as nano shells in drug delivery systems and cancer therapy. Nano shells can recognize the cancer cells when they are injected into the cancer area. The heat generated by the light absorbing nano shells due to the application of the near infrared light successfully kills tumour cells leaving the noncarcinogenic cells intact. In this review article, nanoparticles, the health implication of nanoparticles and their synthesis are discussed.

scholarly journals HOLLOW, BRANCHED AND MULTIFUNCTIONAL NANOPARTICLES: SYNTHESIS, PROPERTIES AND APPLICATIONS

2009 ◽  
Vol 08 (06) ◽  
pp. 483-514 ◽  
Author(s):  
DONGLING MA ◽  
ARNOLD KELL
Keyword(s):  
Mechanical Properties ◽  
Self Assembly ◽  
Photothermal Therapy ◽  
Building Blocks ◽  
Complex Materials ◽  
Multifunctional Nanoparticles ◽  
The Past ◽  
Wide Range ◽  
Nanoparticles Synthesis ◽  
Synthesis Properties

Nanoscale materials with various structures have attracted extensive research interest during the past decade. Among them, hollow, branched and multifunctional nanoparticles comprised of two different nanoparticle components are emerging as new classes of interesting nanomaterials owing to the unique optical, catalytic, electrical, magnetic and mechanical properties associated with their unusual morphologies as well as their potential wide range of applications in various fields such as photothermal therapy, diagnosis, drug delivery, catalysis, optoelectronic, electronics and biodiagnostics. In particular, branched nanoparticles promise to serve as building blocks for more complex materials and advanced devices through self-assembly and self-alignment and heterodimeric nanoparticles show promise for the development of tunable magnetic materials and multimodal biodiagnostic imaging tools.

scholarly journals Advances in Density-Functional Calculations for Materials Modeling

2019 ◽  
Vol 49 (1) ◽  
pp. 1-30 ◽  
Author(s):  
Reinhard J. Maurer ◽  
Christoph Freysoldt ◽  
Anthony M. Reilly ◽  
Jan Gerit Brandenburg ◽  
Oliver T. Hofmann ◽  
...  
Keyword(s):  
Density Functional ◽  
Materials Science ◽  
Inorganic Materials ◽  
The Past ◽  
Biological Matter ◽  
Materials Modeling ◽  
Wide Range ◽  
Low Dimensional ◽  
Low Dimensional Materials

During the past two decades, density-functional (DF) theory has evolved from niche applications for simple solid-state materials to become a workhorse method for studying a wide range of phenomena in a variety of system classes throughout physics, chemistry, biology, and materials science. Here, we review the recent advances in DF calculations for materials modeling, giving a classification of modern DF-based methods when viewed from the materials modeling perspective. While progress has been very substantial, many challenges remain on the way to achieving consensus on a set of universally applicable DF-based methods for materials modeling. Hence, we focus on recent successes and remaining challenges in DF calculations for modeling hard solids, molecular and biological matter, low-dimensional materials, and hybrid organic-inorganic materials.

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