Synthesis and biological evaluation of novel acyclic and cyclic glyoxamide based derivatives as bacterial quorum sensing and biofilm inhibitors

2017 ◽  
Vol 15 (27) ◽  
pp. 5743-5755 ◽  
Author(s):  
Shashidhar Nizalapur ◽  
Onder Kimyon ◽  
Eugene Yee ◽  
Mohan M. Bhadbhade ◽  
Mike Manefield ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Biological Evaluation ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
E Coli ◽  
Sensing Mechanism ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Synthesis And Biological Evaluation

Novel acyclic and cyclic glyoxamides that inhibited quorum sensing mechanism and biofilm formation in Gram-negative bacteria such as P. aeruginosa and E. coli.

Synthesis and biological evaluation of homoserine lactone derived ureas as antagonists of bacterial quorum sensing

2006 ◽  
Vol 14 (14) ◽  
pp. 4781-4791 ◽  
Author(s):  
Marine Frezza ◽  
Sandra Castang ◽  
Jane Estephane ◽  
Laurent Soulère ◽  
Christian Deshayes ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactone ◽  
Biological Evaluation ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Synthesis And Biological Evaluation

scholarly journals IgY Targeting Bacterial Quorum-Sensing Molecules in Implant-Associated Infections

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 4027
Author(s):  
Ulrike Dapunt ◽  
Birgit Prior ◽  
Christopher Oelkrug ◽  
Jan Philippe Kretzer
Keyword(s):  
Quorum Sensing ◽  
Staphylococcus Epidermidis ◽  
Biofilm Formation ◽  
Major Complication ◽  
Underlying Mechanism ◽  
Bacterial Communication ◽  
Bacterial Quorum Sensing ◽  
Polysaccharide Intercellular Adhesion ◽  
Bacterial Quorum ◽  
Treatment Alternatives

Background: Implant-associated infections are still a major complication in the field of orthopedics. Bacteria can form biofilms on implant surfaces, making them more difficult to detect and treat. Since standard antibiotic therapy is often impaired in biofilm infections, particular interest is directed towards finding treatment alternatives. Biofilm-formation is a well-organized process during which bacteria communicate via quorum-sensing molecules (QSM). The aim of this study was to inhibit bacterial communication by directing avian IgY against specific QSM. Methods: Chicken were immunized against the following QSM: (1) AtlE, a member of the autolysin family which mediates attachment to a surface in Staphylococcus epidermidis; (2) GroEL, the bacterial heat shock protein; (3) PIA (polysaccharide intercellular adhesion), which is essential for cell–cell adhesion in biofilms. Staphylococcus epidermidis biofilms were grown and inhibition of biofilm-formation by IgYs was evaluated. Additionally, human osteoblasts were cultivated and biocompatibility of IgYs was tested. Results: We were able to demonstrate that all IgYs reduced biofilm-formation, also without prior immunization. Therefore, the response was probably not specific with regard to the QSM. Osteoblasts were activated by all IgYs which was demonstrated by microscopy and an increased release of IL-8. Conclusions: In conclusion, avian IgY inhibits biofilm-formation, though the underlying mechanism is not yet clear. However, adverse effects on local tissue cells (osteoblasts) were also observed.

scholarly journals Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum

2019 ◽  
Vol 55 (66) ◽  
pp. 9765-9768 ◽  
Author(s):  
Joanna Shepherd ◽  
Thomas Swift ◽  
Chien-Yi Chang ◽  
James R. Boyne ◽  
Stephen Rimmer ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Mode Of Action ◽  
Biofilm Formation ◽  
Chromobacterium Violaceum ◽  
Isopropyl Acrylamide ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action.

Escherichia coli tol and rcs genes participate in the complex network affecting curli synthesis

Microbiology ◽  
2005 ◽  
Vol 151 (7) ◽  
pp. 2487-2497 ◽  
Author(s):  
Anne Vianney ◽  
Grégory Jubelin ◽  
Sophie Renault ◽  
Corine Dorel ◽  
Philippe Lejeune ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Biofilm Formation ◽  
Membrane Integrity ◽  
Regulatory Proteins ◽  
Gram Negative Bacteria ◽  
Dependent Manner ◽  
Dominant Effect ◽  
Gram Negative ◽  
E Coli

Curli are necessary for the adherence of Escherichia coli to surfaces, and to each other, during biofilm formation, and the csgBA and csgDEFG operons are both required for their synthesis. A recent survey of gene expression in Pseudomonas aeruginosa biofilms has identified tolA as a gene activated in biofilms. The tol genes play a fundamental role in maintaining the outer-membrane integrity of Gram-negative bacteria. RcsC, the sensor of the RcsBCD phosphorelay, is involved, together with RcsA, in colanic acid capsule synthesis, and also modulates the expression of tolQRA and csgDEFG. In addition, the RcsBCD phosphorelay is activated in tol mutants or when Tol proteins are overexpressed. These results led the authors to investigate the role of the tol genes in biofilm formation in laboratory and clinical isolates of E. coli. It was shown that the adherence of cells was lowered in the tol mutants. This could be the result of a drastic decrease in the expression of the csgBA operon, even though the expression of csgDEFG was slightly increased under such conditions. It was also shown that the Rcs system negatively controls the expression of the two csg operons in an RcsA-dependent manner. In the tol mutants, activation of csgDEFG occurred via OmpR and was dominant upon repression by RcsB and RcsA, while these two regulatory proteins repressed csgBA through a dominant effect on the activator protein CsgD, thus affecting curli synthesis. The results demonstrate that the Rcs system, previously known to control the synthesis of the capsule and the flagella, is an additional component involved in the regulation of curli. Furthermore, it is shown that the defect in cell motility observed in the tol mutants depends on RcsB and RcsA.

scholarly journals An investigation of the interactions between an E. coli bacterial quorum sensing biosensor and chitosan-based nanocapsules

2017 ◽  
Vol 149 ◽  
pp. 358-368 ◽  
Author(s):  
Xiaofei Qin ◽  
Christoph Engwer ◽  
Saaketh Desai ◽  
Celina Vila-Sanjurjo ◽  
Francisco M. Goycoolea
Keyword(s):  
Quorum Sensing ◽  
E Coli ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

scholarly journals Synthesis and biological evaluation of new Benzimidazole derivatives

2018 ◽  
Vol 29 (1) ◽  
pp. 107 ◽  
Author(s):  
Hadeel Majed ◽  
Firyal W. Askar
Keyword(s):  
Schiff Bases ◽  
Nmr Spectra ◽  
Antimicrobial Activities ◽  
Biological Evaluation ◽  
Benzimidazole Derivatives ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
H Nmr ◽  
Bacteria And Fungi ◽  
Synthesis And Biological Evaluation

Agroup of benzimidazole derivatives bearing different heterocyclic moieties such as Schiff bases, 2-azetidinone and  4-thiazolidinone were efficiently prepared. The structures of the newly compounds were characterized by FTIRand ¹H NMR spectra. The synthesized compounds were evaluated for their antimicrobial activities against gram-positive and gram negative bacteria and fungi using the microdilution procedure.

scholarly journals Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors

MedChemComm ◽  
2019 ◽  
Vol 10 (4) ◽  
pp. 528-537 ◽  
Author(s):  
Geir Kildahl-Andersen ◽  
Christian Schnaars ◽  
Anthony Prandina ◽  
Sylvie Radix ◽  
Marc Le Borgne ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Chelating Compounds ◽  
Synthesis And Biological Evaluation

New MBL inhibitor renders resistant Gram negative bacteria susceptible to carbapenems.

Inhibition of Biofilm Formation in Some Pathogenic Gram Negative Bacteria by Anti-quorum Sensing Compounds

2018 ◽  
Vol 35 (1) ◽  
pp. 111-127
Author(s):  
Fatma, Shaban ◽  
Zeinab. H.Kheiralla ◽  
Abeer, Rushdy ◽  
Khaled, El-Baghdady
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Gram Negative Bacteria ◽  
Gram Negative
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