scholarly journals Diastereoselective synthesis and biological evaluation of enantiomerically pure tricyclic indolines

2017 ◽  
Vol 15 (19) ◽  
pp. 4241-4245 ◽  
Author(s):  
W. He ◽  
B. M. Griffiths ◽  
W. Wang ◽  
X. Wang
Keyword(s):  
Natural Products ◽  
Biological Evaluation ◽  
Diastereoselective Synthesis ◽  
Chemical Probes ◽  
Enantiomerically Pure ◽  
Synthesis And Biological Evaluation

Tricyclic indolines are common in both natural products and synthetic chemical probes.

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

Total synthesis and biological evaluation of ustiloxin natural products and two analogs

2006 ◽  
Vol 16 (18) ◽  
pp. 4804-4807 ◽  
Author(s):  
Pixu Li ◽  
Cory D. Evans ◽  
Erin M. Forbeck ◽  
Haengsoon Park ◽  
Ruoli Bai ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues

MedChemComm ◽  
2019 ◽  
Vol 10 (7) ◽  
pp. 1205-1211
Author(s):  
Alhanouf Z. Aljahdali ◽  
Seth A. Freedman ◽  
Jana Scott ◽  
Miaosheng Li ◽  
George A. O'Doherty
Keyword(s):  
Natural Products ◽  
Biological Evaluation ◽  
Anticancer Activities ◽  
Synthesis And Biological Evaluation

The synthesis and biological evaluation of two phomopsolide natural products (D and E) and two analogues is presented.

scholarly journals Total Synthesis and Biological Evaluation of Phaeosphaerides

Catalysts ◽  
2018 ◽  
Vol 8 (5) ◽  
pp. 206 ◽  
Author(s):  
Kenichi Kobayashi ◽  
Kosaku Tanaka ◽  
Hiroshi Kogen
Keyword(s):  
Crystal Structure ◽  
Natural Products ◽  
Total Synthesis ◽  
Structure Analysis ◽  
Endophytic Fungus ◽  
Biological Evaluation ◽  
Crystal Structure Analysis ◽  
X Ray ◽  
Structure Activity ◽  
Synthesis And Biological Evaluation

This article reviews studies regarding the total synthesis of phaeosphaerides A and B, nitrogen-containing bicyclic natural products isolated from an endophytic fungus. Numerous synthetic efforts and an X-ray crystal structure analysis of phaeosphaeride A have enabled revision of its originally proposed structure. In addition, a successful protic acid-mediated transformation of phaeosphaeride A to phaeosphaeride B revealed the hypothetical biosynthesis of phaeosphaeride B from phaeosphaeride A. Structure–activity relationship studies of phaeosphaeride derivatives are also discussed.

Synthesis and Biological Evaluation of Imidazoquinoxalinones, Imidazole Analogues of Pyrroloiminoquinone Marine Natural Products

2007 ◽  
Vol 50 (19) ◽  
pp. 4561-4571 ◽  
Author(s):  
Hung Hoang ◽  
Daniel V. LaBarbera ◽  
Kaleem A. Mohammed ◽  
Chris M. Ireland ◽  
Edward B. Skibo
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation
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