Development of 19F-NMR chemical shift detection of DNA B–Z equilibrium using 19F-NMR

2017 ◽  
Vol 15 (24) ◽  
pp. 5109-5111 ◽  
Author(s):  
S. Nakamura ◽  
H. Yang ◽  
C. Hirata ◽  
F. Kersaudy ◽  
K. Fujimoto
Keyword(s):  
Chemical Shift ◽  
Conformational Changes ◽  
19F Nmr ◽  
Nmr Chemical Shift ◽  
Single Stranded Dna ◽  
Shift Detection ◽  
Dna Conformational Changes

The DNA conformational changes such as B-formed, Z-formed, and single stranded DNA, were detected in one of 19F-NMR measurements using a fluorine-labeled nucleobase.

Improving the analysis of NMR spectra tracking pH-induced conformational changes: Removing artefacts of the electric field on the NMR chemical shift

2009 ◽  
Vol 78 (4) ◽  
pp. 971-984 ◽  
Author(s):  
Predrag Kukić ◽  
Damien Farrell ◽  
Chresten R. Søndergaard ◽  
Una Bjarnadottir ◽  
John Bradley ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Electric Field ◽  
Conformational Changes ◽  
Nmr Spectra ◽  
Nmr Chemical Shift

19F NMR chemical shift prediction with fluorine fingerprint descriptor

2010 ◽  
Vol 131 (5) ◽  
pp. 570-577 ◽  
Author(s):  
Anna Vulpetti ◽  
Gregory Landrum ◽  
Simon Rüdisser ◽  
Paulus Erbel ◽  
Claudio Dalvit
Keyword(s):  
Chemical Shift ◽  
19F Nmr ◽  
Nmr Chemical Shift ◽  
Chemical Shift Prediction

scholarly journals Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs

PPAR Research ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Tony Velkov
Keyword(s):  
Fatty Acid ◽  
Chemical Shift ◽  
Conformational Changes ◽  
Gene Activation ◽  
Chemical Shift Perturbation ◽  
Peroxisome Proliferator ◽  
Nmr Chemical Shift ◽  
Fatty Acid Binding ◽  
Regulatory Pathways ◽  
Subtype Selective

Fatty acid binding proteins (FABPs) act as intracellular shuttles for fatty acids as well as lipophilic xenobiotics to the nucleus, where these ligands are released to a group of nuclear receptors called the peroxisome proliferator activated receptors (PPARs). PPAR mediated gene activation is ultimately involved in maintenance of cellular homeostasis through the transcriptional regulation of metabolic enzymes and transporters that target the activating ligand. Here we show that liver- (L-) FABP displays a high binding affinity for PPAR subtype selective drugs. NMR chemical shift perturbation mapping and proteolytic protection experiments show that the binding of the PPAR subtype selective drugs produces conformational changes that stabilize the portal region of L-FABP. NMR chemical shift perturbation studies also revealed that L-FABP can form a complex with the PPAR ligand binding domain (LBD) of PPARα. This protein-protein interaction may represent a mechanism for facilitating the activation of PPAR transcriptional activity via the direct channeling of ligands between the binding pocket of L-FABP and the PPARαLBD. The role of L-FABP in the delivery of ligands directly to PPARαvia this channeling mechanism has important implications for regulatory pathways that mediate xenobiotic responses and host protection in tissues such as the small intestine and the liver where L-FABP is highly expressed.

19F NMR CHEMICAL SHIFT IMAGING OF ANESTHETICS IN MODEL MEMBRANES

1984 ◽  
Vol 13 (6) ◽  
pp. 871-872 ◽  
Author(s):  
Yoko Kanazawa ◽  
Wakako Higuchi
Keyword(s):  
Chemical Shift ◽  
Chemical Shift Imaging ◽  
Model Membranes ◽  
19F Nmr ◽  
Nmr Chemical Shift

13C NMR chemical shift trends and conformational changes in alkali metal cation complexes of a series of naphthalene crown ethers

1988 ◽  
Vol 26 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Mark R. Johnson ◽  
Christopher A. Colburn ◽  
Susan J. Ganion ◽  
Byungki Son ◽  
John A. Mosbo ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Alkali Metal ◽  
Crown Ethers ◽  
Conformational Changes ◽  
13C Nmr ◽  
Metal Cation ◽  
Alkali Metal Cation ◽  
Nmr Chemical Shift ◽  
Cation Complexes

Determination of anisotropic solvation structure of octafluorotoluene in supercritical carbon dioxide by means of solvent-induced 19F NMR chemical shift

2001 ◽  
Vol 338 (2-3) ◽  
pp. 95-100 ◽  
Author(s):  
Mitsuhiro Kanakubo ◽  
Tatsuya Umecky ◽  
Hajime Kawanami ◽  
Takafumi Aizawa ◽  
Yutaka Ikushima ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Chemical Shift ◽  
Supercritical Carbon Dioxide ◽  
19F Nmr ◽  
Nmr Chemical Shift ◽  
Solvation Structure ◽  
Supercritical Carbon

86. Kinetics of AsF5 intercalation in highly-oriented pryolytic graphite: Dependence of the 19F NMR chemical shift on stage

Carbon ◽  
1982 ◽  
Vol 20 (2) ◽  
pp. 134
Author(s):  
Gerald Ray Miller ◽  
Lewis Banks ◽  
M.J. Moran ◽  
H.A. Resing
Keyword(s):  
Chemical Shift ◽  
19F Nmr ◽  
Nmr Chemical Shift ◽  
Kinetics Of

Multiplexed detection of nucleic acids using 19F NMR chemical shift changes based on DNA photo-cross-linking of 3-vinylcarbazole derivatives

2018 ◽  
Vol 16 (6) ◽  
pp. 891-894
Author(s):  
Shigetaka Nakamura ◽  
Yasuharu Takashima ◽  
Kenzo Fujimoto
Keyword(s):  
Chemical Shift ◽  
Nucleic Acids ◽  
19F Nmr ◽  
Cross Linking ◽  
Nmr Chemical Shift ◽  
Multiplexed Detection

The 19F NMR identical to trifluorothymidine was large shifted by DNA photo-cross-linking. The shifted signal dispersion was induced by the substituent of 3-vinylcarbazole derivatives.

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