Efficient construction of C–N and C–S bonds in 2-iminothiazoles via cascade reaction of enaminones with potassium thiocyanate

2017 ◽  
Vol 15 (17) ◽  
pp. 3611-3615 ◽  
Author(s):  
Xue-Bing Chen ◽  
Xue-Quan Wang ◽  
Jia-Na Song ◽  
Qing-Li Yang ◽  
Chao Huang ◽  
...  
Keyword(s):  
Potassium Thiocyanate ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Efficient Construction

Regioselective cascade reactions have been developed by using enaminones and potassium thiocyanate, offering a novel protocol for the synthesis of thiazoles from enaminones.

Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides

2018 ◽  
Vol 16 (33) ◽  
pp. 5955-5959
Author(s):  
Jing Wu ◽  
Yuanfang Kong ◽  
Lingyan Liu ◽  
Weixing Chang ◽  
Jing Li
Keyword(s):  
Potassium Thiocyanate ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Acyl Chlorides ◽  
Metal Free

A novel metal-free multicomponent cascade reaction was developed for the construction of thiazine imides.

scholarly journals Synthesis of spiro[benzo[4,5]imidazo[2,1-b][1,3]thiazole-2,3-thiolane]s via sulfa-Michael/aldol cascade reactions

2019 ◽  
Vol 43 (1-2) ◽  
pp. 63-66 ◽  
Author(s):  
Jiaying Lei ◽  
Xinliang Fu ◽  
Yulin Huang ◽  
Xiaofang Li
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Crystallographic Analysis ◽  
X Ray ◽  
Resolution Mass

The sulfa-Michael/aldol cascade reaction of ( Z)-2-arylmethylidene-benzo[4,5]imidazo[2,1- b]thiazol-3(2H)-ones and 1,4-dithiane-2,5-diol afforded novel 2-aryl-4-hydroxy-spiro[benzo[4,5]imidazo[2,1- b][1,3]thiazole-2,3-thiolan]-3-ones in moderate yields. The structures of all the products were characterized thoroughly by nuclear magnetic resonance, infrared and high-resolution mass spectrometry together with X-ray crystallographic analysis.

scholarly journals Brushing the surface: cascade reactions between immobilized nanoreactors

Nanoscale ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 1551-1562 ◽  
Author(s):  
Dalin Wu ◽  
Serena Rigo ◽  
Stefano Di Leone ◽  
Andrea Belluati ◽  
Edwin C. Constable ◽  
...  
Keyword(s):  
Polymer Brushes ◽  
Cascade Reactions ◽  
Cascade Reaction

A tandem cascade reaction between polymer brushes-supported nanoreactors has been demonstrated.

Diversity-Oriented Synthesis of Natural Products via Gold-Catalyzed Cascade Reactions

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1552-1571 ◽  
Author(s):  
Jianxian Gong ◽  
Zhen Yang ◽  
Yueqing Gu ◽  
Ceheng Tan
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Biologically Active ◽  
Synthetic Methods ◽  
Left Wing ◽  
Asymmetric Total Synthesis ◽  
Diversity Oriented Synthesis ◽  
Active Natural

This account describes our group’s latest research in the field of diversity-oriented synthesis of natural products via gold-catalyzed cascade reactions. We present two general strategies based on gold-catalyzed cycloisomerization: a gold-catalyzed cascade reaction of 1,7-diynes and a pinacol-terminated gold-catalyzed cascade reaction. We highlight our development of synthetic methods for the construction of biologically active natural products by using these two strategies.1 Introduction2 Gold-Catalyzed Cascade Reactions of 1,7-Diynes2.1 Collective Synthesis of C15 Oxygenated Drimane-Type Sesquiterpenoids2.2 Synthesis of Left-Wing Fragment of Azadirachtin I2.3 Collective Synthesis of Cladiellins3 Pinacol-Terminated Gold-Catalyzed Cascade Reaction3.1 Asymmetric Formal Total Synthesis of (+)-Cortistatins3.2 Total Synthesis of Orientalol F3.3 Asymmetric Total Synthesis of (–)-Farnesiferol C4 Summary and Outlook

scholarly journals Synthesis of indanes via carbene-catalyzed single-electron-transfer processes and cascade reactions

2017 ◽  
Vol 53 (87) ◽  
pp. 11952-11955 ◽  
Author(s):  
Yuhuang Wang ◽  
Xingxing Wu ◽  
Yonggui Robin Chi
Keyword(s):  
Electron Transfer ◽  
Michael Addition ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Single Electron ◽  
Single Electron Transfer ◽  
Transfer Processes ◽  
Electron Transfer Processes

An NHC-catalyzed cascade reaction involving an SET process and two sequential Michael addition steps for the synthesis of indanes is disclosed.

Double enzymatic cascade reactions within FeSe–Pt@SiO2 nanospheres: synthesis and application toward colorimetric biosensing of H2O2 and glucose

The Analyst ◽  
2015 ◽  
Vol 140 (19) ◽  
pp. 6684-6691 ◽  
Author(s):  
Fengmin Qiao ◽  
Zhenzhen Wang ◽  
Ke Xu ◽  
Shiyun Ai
Keyword(s):  
Colorimetric Detection ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Peroxidase Mimic ◽  
Colorimetric Biosensing

The FeSe–Pt@SiO2 nanospheres possessed both intrinsic GOx- and peroxidase-mimic activities, which realized colorimetric detection of glucose through a cascade reaction.

scholarly journals Heterogeneous Synergistic Catalysis for Promoting Aza-Michael–Henry Tandem Reaction for the Synthesis of Chiral 3-Nitro-1,2-Dihydroquinoline

Catalysts ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 713 ◽  
Author(s):  
Zhe An ◽  
Lifeng Chen ◽  
Yitao Jiang ◽  
Jing He
Keyword(s):  
Secondary Amine ◽  
Tertiary Amine ◽  
Enantiomeric Excess ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Tandem Reaction ◽  
Chiral Amines ◽  
Synergistic Catalysis ◽  
Geometrical Constraints ◽  
Synergistic Mechanism

Heterogeneous synergistic catalysis by SBA-15 immobilized chiral amines catalysts has promoted efficient aza-Michael–Henry tandem reaction for the synthesis of chiral 3-Nitro-1,2-Dihydroquinoline. Final products in the asymmetric aza-Michael–Henry cascade reactions between 2-aminobenzaldehyde and β-nitrostyrolene were afforded in a yield of 85% and an enantiomeric excess (ee) value of 98% on (S)-(–)-2-aminomethyl-1-ethylpyrrolidine immobilized SBA-15. SBA-15-AEP catalyst has been also extended to the asymmetric aza-Michael–Henry cascade reaction of substituted R1-2-aminobenzaldehyde and R2-substituted nitroolefin. The heterogeneous synergistic mechanism for both tertiary amine and secondary amine immobilized mesoporous has been proposed in detail including the geometrical constraints in the ee promotion.

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