One-pot construction of sterically challenging and diverse polyarylphenols via transition-metal-free benzannulation and their potent in vitro antioxidant activity

2017 ◽  
Vol 15 (9) ◽  
pp. 2052-2062 ◽  
Author(s):  
Shizuka Mei Bautista Maezono ◽  
Tej Narayan Poudel ◽  
Yong Rok Lee
Keyword(s):  
Antioxidant Activity ◽  
Transition Metal ◽  
Antioxidant Activities ◽  
One Pot ◽  
Metal Free ◽  
Novel Synthesis ◽  
In Vitro Antioxidant Activity

One pot novel synthesis of highly functionalized polyarylphenols via benzannulation under transition-metal-free conditions and their antioxidant activities are described.

scholarly journals Green Synthesis, Characterization and In-vitro Antioxidant Property of Silver Nanoparticles Using the Aqueous Leaf Extract of Justicia carnea

2021 ◽  
pp. 20-30
Author(s):  
I. O. Salaudeen ◽  
M. O. Olajuwon ◽  
A. B. Ajala ◽  
T. O. Abdulkareem ◽  
S. A. Adeniyi ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Silver Nanoparticles ◽  
Leaf Extract ◽  
Antioxidant Activities ◽  
Silver Ions ◽  
Antioxidant Property ◽  
Biological Macromolecules ◽  
Aqueous Leaf Extract ◽  
In Vitro Antioxidant Activity

This study investigated the synthesis, characterization and in vitro antioxidant activity of silver nanoparticles (AgNPs) using the aqueous leaf extract of Justicia carnea.  The aqueous leaf extract of J. carnea was used as a potential reducing and capping agent. To identify the compounds responsible for the reduction of silver ions, the functional groups present in the plant extract were subjected to FTIR. The in vitro antioxidant activity of synthesized nanoparticles was evaluated in terms of ferric reducing antioxidant potential (FRAP), DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2`-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) free radicals scavenging assays. The surface plasmon resonance confirmed the formation of AgNPs with maximum absorbance at kmax = 446 nm. FTIR revealed the biological macromolecules of J. carnea leaf extract involved in the synthesis and stabilization of AgNPs. UV-Visible spectrophotometer showed absorbance peak in the range of 436-446 nm. The silver nanoparticles exhibited moderate antioxidant activities compared to standard antioxidants (ascorbic acid and BHT). These results confirmed this protocol as simple, eco-friendly, nontoxic and an alternative for conventional physical and chemical methods. It can be concluded that J. carnea leaf extract can be used effectively in the production of potential antioxidant AgNPs which could be useful in various bio-applications such as cosmetics, food and biomedical industry.

Estimation of Total Phenolics and Flavonoid Content and In-vitro Antioxidant Activity of Drypetes sepiaria Stem (Wight and Arn.) Pax and K. Hoffm.

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Packia M. ◽  
Daffodil D. ◽  
Tresina S. ◽  
Mohan R.
Keyword(s):  
Antioxidant Activity ◽  
Total Phenolics ◽  
Antioxidant Activities ◽  
Reducing Power ◽  
Model Systems ◽  
Aluminium Chloride ◽  
Total Phenolic ◽  
Ethanol Extracts ◽  
In Vitro Antioxidant Activity

The total phenolics, flavonoids and in vitro antioxidant activity of petroleum ether, benzene, ethyl acetate, methanol and ethanol extracts of stem of Drypetes sepiaria were determined using various antioxidant model systems viz, DPPH, hydroxyl, superoxide, ABTS and reducing power. Total phenolic content was estimated by Folin-Ciocalteau method. Flavonoids were determined by Aluminium chloride method. The total phenolics and flavonoids contents were found to be 0.81 g 100 g-1 and 1.12g 100 g-1 respectively in the methanol extract. Among the solvent tested, methanol and ethanol extracts of D. sepiaria stem showed potent in vitro antioxidant activities. This investigation explored that D. sepiaria stem is a potential source of natural antioxidant.

Vitamin C in Acerola and Red Plum Extracts: Quantification via HPLC, in Vitro Antioxidant Activity, and Stability of their Gel and Emulsion Formulations

2018 ◽  
Vol 101 (5) ◽  
pp. 1461-1465 ◽  
Author(s):  
Letícia Caramori Cefali ◽  
Ludmila de Oliveira Maia ◽  
Rebeca Stahlschimidt ◽  
Janaína Artem Ataide ◽  
Elias Basile Tambourgi ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Free Radicals ◽  
Vitamin C ◽  
Antioxidant Activities ◽  
Accelerated Aging ◽  
Stability Study ◽  
Transparent Glass ◽  
Glass Containers ◽  
In Vitro Antioxidant Activity

Abstract Background: The fruits acerola and red plum are known to be good sources of antioxidants, particularly vitamin C. Antioxidants are compounds that protect organisms from biomolecular damage, such as accelerated aging, caused by free radicals. Objective: The objective of this study was to extract vitamin C from acerola and red plum, incorporate these extracts into different topical formulations, and evaluate the physicochemical stabilities of these formulations under stress conditions. Methods: Vitamin C was extracted from acerola and red plum via dynamic maceration for 2 h at 50 ± 2°C and was quantified via HPLC. In vitro antioxidant activities were evaluated using DPPH assays. The extracts were then incorporated into emulsion and gel formulations in two types of packaging, and stability studies were carried out. Results: Red plum and acerola extracts were orange and red and contained vitamin C concentrations of 2732.70 ± 93.01 mg/100 g and 2.60 ± 1.2 mg/100 g, respectively. In vitro antioxidant activity resulted in over 90.0% inhibition of free radicals at 0.01 mL/mL acerola extract and 0.1 mL/mL red plum extract. In the stability study, pH values decreased for both acerola formulations when stored in the oven or in transparent glass containers. Formulations containing red plum extract were stable under all conditions. Acerola extracts contained a higher concentration of vitamin C than red plum extracts. Both extracts possessed antioxidant activity, although the acerola-based formulation was unstable when stored at high temperatures or in transparent glass containers. Highlights: Extracts from red plum and acerola contained vitamin C; antioxidant activity of the extracts resulted in over 90.0% inhibition of free radicals. Formulations containing red plum were stable under all tested conditions, and formulations containing acerola were unstable when stored in the oven or in transparent glass containers.

Antioxidant Components and Antioxidant Activities of Hydroglyceroalcoholic Extract from Fresh Mushroom Mycelium

2017 ◽  
Vol 68 (3) ◽  
pp. 534-540
Author(s):  
Emanuel Vamanu
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Phenolic Acid ◽  
Antioxidant Activities ◽  
Submerged Cultivation ◽  
Active Components ◽  
Gentisic Acid ◽  
Polyphenolic Acids ◽  
In Vitro Antioxidant Activity

The in vitro antioxidant activity, as well as the hydroglyceroalcoholic extracts main active components from mycelia of Pleurotus ostreatus and Coprinus comatus, were determined. The mycelium submitted for extraction was obtained by submerged cultivation in a bioreactor. The hydroglyceroalcoholic extracts, in particular, those of P. ostreatus PSI101109 and PQMZ91109 mycelium had a considerable antioxidant activity, and was compared to the overall constituent of flavonoids plus phenolic compounds. According to the extracts HPLC assessment, the key phenolic acid evident from the extracts was gentisic acid. The homogentisic, gallic and protocatechuic acids were also determined. Catechin was identified as well, except for C. comatus M8102 and P. ostreatus PBS281009 mycelia extracts. Since catechol and gentisic acid levels were high, respectively, there was a correlation with the absence of carotenoid compounds in hydroglyceroalcoholic extracts (P. ostreatus PSI101109). There is a correspondence between the hydroglyceroalcoholic extracts� key antioxidant activities with the catechin and polyphenolic acids levels identified in each extract.

scholarly journals The In Vivo Antioxidant and Hepatoprotective Actions of Selected Chinese Teas

Foods ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 262
Author(s):  
Shi-Yu Cao ◽  
Bang-Yan Li ◽  
Ren-You Gan ◽  
Qian-Qian Mao ◽  
Yuan-Feng Wang ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
In Vitro Study ◽  
Total Phenolic ◽  
Gallocatechin Gallate ◽  
Dietary Components ◽  
The Relationship ◽  
In Vitro Antioxidant Activity

Tea is a popular beverage and shows very strong in vitro antioxidant activity. However, the relationship among in vitro and in vivo antioxidant activities in teas is seldom reported. In this study, in vivo antioxidant and hepatoprotective activities of 32 selected Chinese teas were evaluated on a mouse model with acute alcohol-induced liver injury. The results showed that most teas significantly reduced the levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, triacylglycerol, and total bilirubin in the sera of mice at a dose of 400 mg/kg. In addition, most teas greatly decreased the malondialdehyde level and increased the levels of superoxide dismutase, glutathione peroxidase, and glutathione in the liver of mice, indicating the antioxidant and hepatoprotective activities of teas. Furthermore, the in vivo antioxidant activity of dark tea was stronger than that of green tea, opposite to the results of the in vitro study. Among these 32 teas, Black Fu Brick Tea, Pu-erh Tea, and Qing Brick Tea showed the strongest antioxidant and hepatoprotective activities. Moreover, total phenolic content as well as the contents of epicatechin, gallocatechin gallate, and chlorogenic acid were found to contribute, at least partially, to the antioxidant and hepatoprotective actions of these teas. Overall, teas are good dietary components with antioxidant and hepatoprotective actions.

scholarly journals Hypolipidemic and Antioxidant Activities of Corrigiola telephiifolia in Diabetic Rats

2019 ◽  
Vol 17 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Morad Hebi ◽  
Mohamed Eddouks
Keyword(s):  
Antioxidant Activity ◽  
Aqueous Extract ◽  
Antioxidant Activities ◽  
Diabetic Rats ◽  
Plasma Triglyceride ◽  
Plasma Total Cholesterol ◽  
Aerial Parts ◽  
Cholesterol Levels ◽  
In Vitro Antioxidant Activity

Objective: The evaluation of the hypolipidemic and antioxidant activities of the aerial parts aqueous extract of Corrigiola telephiifolia (APAE of C. telephiifolia) in normal and streptozotocin (STZ)-induced diabetic rats. Methods: The effects of oral administration of APAE of C. telephiifolia (5 mg/kg) on the lipid profile as well as the in vitro antioxidant activity of this aqueous extract have been determined. Results: APAE of C. telephiifolia (5 mg/kg) reduced significantly (p<0.001) the plasma total cholesterol levels in diabetic rats. In contrast, no significant increase in plasma triglyceride levels in normal and in STZ-induced diabetic rats was observed. On the other hand, APAE of C. telephiifolia showed an antioxidant activity. Conclusion: The APAE of C. telephiifolia exhibits an antioxidant, cholesterol and body weightlowering activities in diabetic rats.

scholarly journals QUANTITATIVE PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT ACTIVITIES OF SOME CITRUS FRUITS OF SOUTH INDIA

2017 ◽  
Vol 10 (12) ◽  
pp. 198
Author(s):  
Pallavi M` ◽  
Ramesh Ck ◽  
Krishna V ◽  
Sameera Parveen ◽  
Nanjunda Swamy L
Keyword(s):  
Antioxidant Activity ◽  
South India ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Phytochemical Analysis ◽  
Citrus Fruits ◽  
Lipid Peroxidation Inhibition ◽  
In Vitro Antioxidant Activity

Objective: The current investigation was contemplated to evaluate the phytochemicals and in vitro antioxidant activities in peel and pulp of some commercially grown citrus fruits of South India, namely, lemon (Citrus aurantifolia), orange (Citrus reticulata), sour orange (Citrus aurantium), pomello (Citrus grandis), and citron (Citrus medica).Methods: The peel and pulp of the fruits were separated and subjected to cold extraction using 70% alcohol. The extracts obtained were screened for the presence of their phytoconstituents using various qualitative and further quantified for major constituents. Further, the in vitro antioxidant activity was assayed by different radical scavenging methods, namely, 2,2-diphenyl-1-picrylhydrazyl, superoxide anion, nitric oxide, lipid peroxidation inhibition, iron chelating activity, and reducing power assay at different concentrations.Results: All the citrus fruits have shown significant in vitro antioxidant activity for the parameters assessed, wherein peel extracts recorded superior antioxidant potential than their corresponding pulps. The broad range of activity of the extracts suggests that multiple mechanisms mediated by the phytoconstituents are responsible for the antioxidant activity.Conclusion: The study thus revealed that peel and pulp of citrus fruits are potential sources of bioactive compounds which are reflected in antioxidant activity and supports their health-promoting claims of plethora of investigations.

scholarly journals In vitro Antioxidant Activities of Hydroethanolic Extract of Defatted Wonderful Kola (Buchholzia coriacea) Seeds and Its Safety Evaluation in Murine Models

2020 ◽  
pp. 17-29
Author(s):  
Ayokanmi Ore ◽  
Regina Ngozi Ugbaja ◽  
Abideen Idowu Adeogun ◽  
Oluseyi Adeboye Akinloye
Keyword(s):  
Antioxidant Activity ◽  
Body Weight ◽  
Antioxidant Activities ◽  
Total Phenols ◽  
Limited Information ◽  
Vast Number ◽  
Limit Test ◽  
Hydroethanolic Extract ◽  
In Vitro Antioxidant Activity

Introduction: Buccholzia coriaceaseed possesses a vast number of therapeutic applications in African traditional medicine. However, there are still limited information on its bioactive constituents, pharmacological actions and safety profile. This study was designed to prepare hydroethanolic extract of (defatted) Buccholzia coriacea seeds (HEBCS), evaluate its total phenols and flavonoids, in vitro antioxidant activity and its safety in rats and mice. Methods: Seeds were defatted with hexane and the residue extracted with 80% ethanol (EtOH). The total phenols and flavonoid content of the lyophilised HEBCS was determined followed by in vitro antioxidant activity against stable free radicals (DPPHŸ, ABTSŸ+) and reactive oxygen species (ŸOH, NO and H2O2). Limit test (at 5000 mg/ kg body weight (bw) and acute toxicity test (at doses of 62.5, 125, 250 and 500 mg/kg bw) was carried out in rats followed by sub chronic toxicity study (at doses of 125 and 250 mg/ kg bw) in mice. Biomarkers of hepatic function (ALT, AST, ALP and total bilirubin) and renal function (urea and creatinine) were assessed. Results: The total phenols and flavonoids content of HEBCS was found to be 31.76 μg GAE/ mg and 22.82 μg QE/ mg respectively. The half-maximal inhibitory concentration (IC50) value for HEBCS when tested against DPPHŸ, ABTSŸ+, ŸOH, H2O2 and NO were found to be 257.85, 496.73, 883.68, 475.68 and 1786.42 μg/mL respectively. The Median Lethality Dose (LD50) for HEBCS in rat was greater than 5000 mg/ kg body weight. HEBCS did not show any significant (P = .05) hepatic or renal toxicity. Conclusion: Data obtained from the present study highlight the safety of HEBCS and its potential role as a source of natural antioxidants.

Metal Free Multicomponent Synthesis and In vitro Antioxidant Activity of Indolylpyrazolopyrimidines

2021 ◽  
Author(s):  
Nadiveedhi Maheshwara Reddy ◽  
Shaik Mahammad Sadik ◽  
Krishnammagari Suresh Kumar ◽  
Suresh Reddy Cirandur
Keyword(s):  
Antioxidant Activity ◽  
Multicomponent Synthesis ◽  
Metal Free ◽  
In Vitro Antioxidant Activity
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