Organelle-targeting surface-enhanced Raman scattering (SERS) nanosensors for subcellular pH sensing

Nanoscale ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 1622-1630 ◽  
Author(s):  
Yanting Shen ◽  
Lijia Liang ◽  
Shuqin Zhang ◽  
Dianshuai Huang ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Raman Scattering ◽  
High Sensitivity ◽  
Surface Enhanced Raman Scattering ◽  
Ph Sensing ◽  
Ph Values ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Organelle Targeting

A series of surface-enhanced Raman scattering (SERS) nanosensors with high sensitivity and targeting function was prepared for the quantification and monitoring of pH values in mitochondria, nucleus, and lysosome.

scholarly journals Detection of Organic Substances by a SERS Method Using a Special Ag-Poly(Chloro-P-Xylylene)-Ag Sandwich Substrate

Coatings ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 799
Author(s):  
Irina Boginskaya ◽  
Aliia Gainutdinova ◽  
Alexey Gusev ◽  
Karen Mailyan ◽  
Anton Mikhailitsyn ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Sandwich Structures ◽  
Control Sample ◽  
Film Surface ◽  
High Sensitivity ◽  
Surface Enhanced Raman Scattering ◽  
Silver Layer ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Spectroscopy based on surface enhanced Raman scattering (SERS) is widely used as a method with extremely high sensitivity for molecular and chemical analysis. We have developed thin-film sandwich structures, in which, when used as sensitive elements for detecting organic compounds at low concentrations, high-amplitude spectra of surface enhanced Raman scattering are observed. Using gas-phase cryochemical synthesis and thermal sputtering in vacuum, SERS active sandwich structures Ag–poly(chloro-p-xylylene)–Ag (Ag–PCPX–Ag) were obtained. In the process of creating sandwich structures, the upper silver film takes the form of a complex island topology with submicron sizes. A series of samples were made with different thicknesses of the polymer and upper silver layers. SERS spectra of the analyte chemically adsorbed on the film surface were obtained, demonstrating a significant amplification (up to 104) compared with the control sample. The dependence of the gain on the silver concentration is characterized by a maximum polymer layer thickness of 600 nm and a 30 nm thick upper silver layer. A selective amplification of the low molecular weight compound spectra with respect to proteins was observed. A semi-empirical model is proposed that is in good agreement with the experimental results.

Surface-enhanced Raman scattering on a zigzag microfluidic chip: towards high-sensitivity detection of As(iii) ions

2014 ◽  
Vol 6 (12) ◽  
pp. 4077-4082 ◽  
Author(s):  
Nan Qi ◽  
Bowei Li ◽  
Huiyan You ◽  
Wei Zhang ◽  
Longwen Fu ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Raman Scattering ◽  
Microfluidic Chip ◽  
High Sensitivity ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
High Sensitivity Detection ◽  
Sensitivity Detection

A quantitative sensitivity analysis for trace As(iii) ions was proposed based on the SERS technique on a zigzag microfluidic chip.

scholarly journals A Review on Surface-Enhanced Raman Scattering

Biosensors ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 57 ◽  
Author(s):  
Pilot ◽  
Signorini ◽  
Durante ◽  
Orian ◽  
Bhamidipati ◽  
...  
Keyword(s):  
Raman Scattering ◽  
High Sensitivity ◽  
Surface Enhanced Raman Scattering ◽  
Fingerprint Recognition ◽  
Excitation Wavelength ◽  
User Friendliness ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
The Cost

Surface-enhanced Raman scattering (SERS) has become a powerful tool in chemical, material and life sciences, owing to its intrinsic features (i.e., fingerprint recognition capabilities and high sensitivity) and to the technological advancements that have lowered the cost of the instruments and improved their sensitivity and user-friendliness. We provide an overview of the most significant aspects of SERS. First, the phenomena at the basis of the SERS amplification are described. Then, the measurement of the enhancement and the key factors that determine it (the materials, the hot spots, and the analyte-surface distance) are discussed. A section is dedicated to the analysis of the relevant factors for the choice of the excitation wavelength in a SERS experiment. Several types of substrates and fabrication methods are illustrated, along with some examples of the coupling of SERS with separation and capturing techniques. Finally, a representative selection of applications in the biomedical field, with direct and indirect protocols, is provided. We intentionally avoided using a highly technical language and, whenever possible, intuitive explanations of the involved phenomena are provided, in order to make this review suitable to scientists with different degrees of specialization in this field.

scholarly journals One Step Fabrication of Highly Absorptive and Surface Enhanced Raman Scattering (SERS) Silver Nano-trees on Silicon Substrate

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sara Abdel Razek ◽  
Ahmed B. Ayoub ◽  
Mohamed A. Swillam
Keyword(s):  
Raman Scattering ◽  
Ethylene Glycol ◽  
Silicon Substrate ◽  
Enhancement Factor ◽  
High Sensitivity ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
One Step ◽  
Enhanced Raman Scattering

Abstract Silver Nano-trees (AgNTs) were synthesized by one-step electroless method with different densities via water or ethylene glycol (EG) on silicon substrate in one minute. The density of AgNTs is controlled by changing the concentration of silver nitrate in etchant solution. The absorption of NTs fabricated via EG is higher than absorption of NTs without EG. The AgNTs are employed as substrates for surface-enhanced Raman scattering (SERS) and exhibit high sensitivity. The silver Nano-trees fabricated via ethylene glycol (AgNTs-EG) enhances the Raman spectrum of pyridine (Py) with higher enhancement factor. Moreover, the SERS-active substrates prepared by using EG were able to detect Pyridine with concentration as low as 0.005 mM, the ones fabricated by water could only detect Pyridine at concentration of 0.2 mM.

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