Triphenylamine flanked furan-diketopyrrolopyrrole for multi-imaging guided photothermal/photodynamic cancer therapy

Nanoscale ◽  
2017 ◽  
Vol 9 (47) ◽  
pp. 18890-18896 ◽  
Author(s):  
Pingping Liang ◽  
Ya Wang ◽  
Peng Wang ◽  
Jianhua Zou ◽  
Hong Xu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photodynamic Cancer Therapy ◽  
Donor Acceptor ◽  
Photothermal Imaging

A near-infrared donor–acceptor–donor agent of triphenylamine flanked furan-diketopyrrolopyrrole nanoparticles is designed and synthesized for fluorescence, photoacoustic and photothermal imaging guided synergistic photodynamic and photothermal therapy (PDT/PTT).

Bi19S27I3 nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

Nanoscale ◽  
2021 ◽  
Author(s):  
Jinsong Xiong ◽  
Qinghuan Bian ◽  
Shuijin Lei ◽  
Yatian Deng ◽  
Kehan Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Research Interest ◽  
The Past ◽  
Nir Light ◽  
Considerable Research ◽  
Key Factor

Near-infrared (NIR) light induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in the photothermal therapy...

scholarly journals Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Songtao Zhang ◽  
Longhai Jin ◽  
Jianhua Liu ◽  
Yang Liu ◽  
Tianqi Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Bovine Serum Albumin ◽  
Synergistic Effect ◽  
Bovine Serum ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Photothermal Effect ◽  
Reaction Efficiency

AbstractIn spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

scholarly journals Melanoma Cancer Therapy Using PEGylated Nanoparticles and Semiconductor Laser

2021 ◽  
Author(s):  
Abdorreza Asrar ◽  
Zahra Sobhani ◽  
Mohammad Ali Behnam
Keyword(s):  
Cancer Therapy ◽  
Laser Beam ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Histopathological Study ◽  
Melanoma Tumor ◽  
Tio2 Nps ◽  
Melanoma Cancer ◽  
Murine Melanoma ◽  
Pegylated Nanoparticles

Purpose: Photothermal therapy is a procedure that converts laser beam energy to heat so can disturb tumor cells. Carbon nanotubes (CNTs) have unique properties in absorption optical energy and could change optical power into heat in photothermal therapy procedures. Additionally, titanium dioxide (TiO2) NPs have a unique feature in absorbing and scattering light. Therefore, these mentioned NPs could play a synergistic role in the photothermal therapy method. Methods: CNTs and TiO2 NPs were injected into the melanoma tumor sites of cancerous mice. Then sites were excited using the laser beam (λ= 808nm, P= 2W, and I= 4W/cm2). Injected NPs caused hyperthermia in solid tumors. Tumor size assay, statistical analysis, and histopathological study of the treated cases were performed to assess the role of mentioned NPs in photothermal therapy of murine melanoma cancer. Results: The results showed that CNTs performed better than TiO2 NPs in destroying murine melanoma cancer cells in animals. Conclusion: The present study compared the photothermal activity of excited CNTs and TiO2 NPs in cancer therapy at the near-infrared spectrum of light. Tumors were destroyed selectively because of their weakened heat resistance versus normal tissue. Photothermal therapy of malignant melanoma through CNTs caused remarkable necrosis into the tumor tissues versus TiO2 NPs.

scholarly journals Hyaluronic Acid-Conjugated Carbon Nanomaterials for Enhanced Tumour Targeting Ability

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 48
Author(s):  
Oisin Kearns ◽  
Adalberto Camisasca ◽  
Silvia Giordani
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Carbon Nanomaterials ◽  
Graphene Quantum Dots ◽  
Tumour Volume ◽  
The Novel ◽  
Targeting Ability

Hyaluronic acid (HA) has been implemented for chemo and photothermal therapy to target tumour cells overexpressing the CD44+ receptor. HA-targeting hybrid systems allows carbon nanomaterial (CNM) carriers to efficiently deliver anticancer drugs, such as doxorubicin and gemcitabine, to the tumour sites. Carbon nanotubes (CNTs), graphene, graphene oxide (GO), and graphene quantum dots (GQDs) are grouped for a detailed review of the novel nanocomposites for cancer therapy. Some CNMs proved to be more successful than others in terms of stability and effectiveness at removing relative tumour volume. While the literature has been focused primarily on the CNTs and GO, other CNMs such as carbon nano-onions (CNOs) proved quite promising for targeted drug delivery using HA. Near-infrared laser photoablation is also reviewed as a primary method of cancer therapy—it can be used alone or in conjunction with chemotherapy to achieve promising chemo-photothermal therapy protocols. This review aims to give a background into HA and why it is a successful cancer-targeting component of current CNM-based drug delivery systems.

scholarly journals Precise and Efficient Phototheranostics: Molecular Engineering of Photosensitizers with Near-Infrared Aggregation-Induced Emission for Acid-Triggered Nucleus-Targeted Photodynamic Cancer Therapy

2020 ◽  
Author(s):  
Zhijun Zhang ◽  
Wenhan XU ◽  
Peihong Xiao ◽  
Miaomiao Kang ◽  
Dingyuan Yan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Fluorescence Emission ◽  
Molecular Engineering ◽  
Ros Generation ◽  
Subcellular Targeting ◽  
Aggregation Induced Emission ◽  
Photodynamic Cancer Therapy

Phototheranostics involving both fluorescence imaging (FLI) and photodynamic therapy (PDT) has been recognized to be potentially powerful for cancer treatment by virtue of various intrinsic advantages. However, the state-of-the-art materials in this area are still far from ideal towards practical applications, owing to their respective and collective drawbacks, such as inefficient imaging quality, inferior reactive oxygen species (ROS) production, the lack of subcellular-targeting capability, and dissatisfactory theranostics delivery. In this contribution, these shortcomings are successfully addressed through the integration of finely engineered photosensitizers having aggregation-induced emission (AIE) features and well tailored nanocarrier system. The yielded AIE NPs simultaneously exhibit broad absorption in visible light region, bright near-infrared fluorescence emission, extremely high ROS generation, as well as tumor lysosomal acidity-activated and nucleus-targeted delivery functions, making them dramatically promising for precise and efficient phototheranostics. Both in vitro and in vivo evaluations show that the presented nanotheranostic system bearing excellent photostability and appreciable biosecurity well performed in FLI-guided photodynamic cancer therapy. This study thus not only extends the applications scope of AIE nanomaterials, but also offers useful insights into constructing a new generation of cancer theranostics.

scholarly journals Near-Infrared Fluorescent pH Responsive Probe for Targeted Photodynamic Cancer Therapy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Siriwalee Siriwibool ◽  
Nantawat Kaekratoke ◽  
Kantapat Chansaenpak ◽  
Kittipan Siwawannapong ◽  
Pannipa Panajapo ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Near Infrared ◽  
Ph Responsive ◽  
Photodynamic Cancer Therapy

Near-Infrared-Absorbing Gold Nanopopcorns with Iron Oxide Cluster Core for Magnetically Amplified Photothermal and Photodynamic Cancer Therapy

2015 ◽  
Vol 7 (21) ◽  
pp. 11637-11647 ◽  
Author(s):  
Saheel Bhana ◽  
Gan Lin ◽  
Lijia Wang ◽  
Hunter Starring ◽  
Sanjay R. Mishra ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Therapy ◽  
Near Infrared ◽  
Cluster Core ◽  
Oxide Cluster ◽  
Photodynamic Cancer Therapy

scholarly journals Enzyme-Loaded pH-Sensitive Photothermal Hydrogels for Mild-temperature-mediated Combinational Cancer Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Jindong Xia ◽  
Xueqin Qing ◽  
Junjian Shen ◽  
Mengbin Ding ◽  
Yue Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Photothermal Effect ◽  
Photothermal Conversion ◽  
Normal Tissues ◽  
Turn On ◽  
Shock Proteins ◽  
Mild Temperature

Photothermal therapy (PTT) that utilizes hyperthermia to ablate cancer cells is a promising approach for cancer therapy, while the generated high temperature may lead to damage of surrounding normal tissues and inflammation. We herein report the construction of glucose oxidase (GOx)-loaded hydrogels with a pH-sensitive photothermal conversion property for combinational cancer therapy at mild-temperature. The hydrogels (defined as CAG) were formed via coordination of alginate solution containing pH-sensitive charge-transfer nanoparticles (CTNs) as the second near-infrared (NIR-II) photothermal agents and GOx. In the tumor sites, GOx was gradually released from CAG to consume glucose for tumor starvation and aggravate acidity in tumor microenvironment that could turn on the NIR-II photothermal conversion property of CTNs. Meanwhile, the released GOx could suppress the expression of heat shock proteins to enable mild NIR-II PTT under 1,064 nm laser irradiation. As such, CAG mediated a combinational action of mild NIR-II PTT and starvation therapy, not only greatly inhibiting the growth of subcutaneously implanted tumors in a breast cancer murine model, but also completely preventing lung metastasis. This study thus provides an enzyme loaded hydrogel platform with a pH-sensitive photothermal effect for mild-temperature-mediated combinational cancer therapy.

scholarly journals Precise and Efficient Phototheranostics: Molecular Engineering of Photosensitizers with Near-Infrared Aggregation-Induced Emission for Acid-Triggered Nucleus-Targeted Photodynamic Cancer Therapy

2020 ◽  
Author(s):  
Zhijun Zhang ◽  
Wenhan XU ◽  
Peihong Xiao ◽  
Miaomiao Kang ◽  
Dingyuan Yan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Fluorescence Emission ◽  
Molecular Engineering ◽  
Ros Generation ◽  
Subcellular Targeting ◽  
Aggregation Induced Emission ◽  
Photodynamic Cancer Therapy

Phototheranostics involving both fluorescence imaging (FLI) and photodynamic therapy (PDT) has been recognized to be potentially powerful for cancer treatment by virtue of various intrinsic advantages. However, the state-of-the-art materials in this area are still far from ideal towards practical applications, owing to their respective and collective drawbacks, such as inefficient imaging quality, inferior reactive oxygen species (ROS) production, the lack of subcellular-targeting capability, and dissatisfactory theranostics delivery. In this contribution, these shortcomings are successfully addressed through the integration of finely engineered photosensitizers having aggregation-induced emission (AIE) features and well tailored nanocarrier system. The yielded AIE NPs simultaneously exhibit broad absorption in visible light region, bright near-infrared fluorescence emission, extremely high ROS generation, as well as tumor lysosomal acidity-activated and nucleus-targeted delivery functions, making them dramatically promising for precise and efficient phototheranostics. Both in vitro and in vivo evaluations show that the presented nanotheranostic system bearing excellent photostability and appreciable biosecurity well performed in FLI-guided photodynamic cancer therapy. This study thus not only extends the applications scope of AIE nanomaterials, but also offers useful insights into constructing a new generation of cancer theranostics.

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