Nanomechanical clinical coagulation diagnostics and monitoring of therapies

Nanoscale ◽  
2017 ◽  
Vol 9 (45) ◽  
pp. 17939-17947 ◽  
Author(s):  
Francesco Padovani ◽  
James Duffy ◽  
Martin Hegner
Keyword(s):  
Blood Coagulation ◽  
Blood Coagulation Disorders ◽  
Coagulation Disorders ◽  
Novel Strategy

Nanoscillations of microcantilevers as a novel strategy to diagnose and monitor blood coagulation disorders, using a few microliters of the sample.

scholarly journals Snakebites by Bothrops spp in children in Campinas, São Paulo, Brazil

2001 ◽  
Vol 43 (6) ◽  
pp. 329-333 ◽  
Author(s):  
Fábio BUCARETCHI ◽  
Sílvia Regina Fontoura HERRERA ◽  
Stephen HYSLOP ◽  
Emílio Carlos Elias BARACAT ◽  
Ronan José VIEIRA
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Compartment Syndrome ◽  
Blood Coagulation ◽  
Sao Paulo ◽  
Blood Coagulation Disorders ◽  
Local Infection ◽  
Coagulation Disorders ◽  
H2 Antagonists ◽  
Clinical Complications

From January, 1984 to March, 1999, 73 children under 15 y old (ages 1-14 y, median 9 y) were admitted after being bitten by snakes of the genus Bothrops. Twenty-six percent of the children were classified as mild envenoming, 50.7% as moderate envenoming and 20.6% as severe envenoming. Two patients (2.7%) showed no signs of envenoming. Most of the patients presented local manifestations, mainly edema (94.5%), pain (94.5%) ecchymosis (73.9%) and blisters (11%). Local and/or systemic bleeding was observed in 28.8% of the patients. Before antivenom (AV) administration, blood coagulation disorders were observed in 60.7% (incoagulable blood in 39.3%) of the 56 children that received AV only in our hospital. AV early reactions, most of which were considered mild, were observed in 44.6% of these cases (in 15/30 patients not pretreated and in 10/26 patients pretreated with hydrocortisone and histamine H1 and H2 antagonists). The main clinical complications observed were local infection (15.1%), compartment syndrome (4.1%), gangrene (1.4%) and acute renal failure (1.4%). No deaths were recorded. There were no significant differences with regard to severity of envenoming versus the frequency of blood coagulation disorders among the three categories of envenoming (p = 0.75) or in the frequency of patients with AV early reactions between the groups that were and were not pretreated (p = 0.55). The frequency of local infection was significantly greater in severe cases (p < 0.001). Patients admitted more than 6 h after the bite had a higher risk of developing severe envenoming (p = 0.04).

Acute intrinsic renal failure and blood coagulation disorders after a snakebite in a dog

1995 ◽  
Vol 36 (7) ◽  
pp. 333-336 ◽  
Author(s):  
J. Puig ◽  
M. Vilafranca ◽  
A. Font ◽  
J. Closa ◽  
M. Pumarola ◽  
...  
Keyword(s):  
Renal Failure ◽  
Blood Coagulation ◽  
Blood Coagulation Disorders ◽  
Coagulation Disorders

I All-Union conference "vascular wall damage and hemostasis"

1982 ◽  
Vol 63 (1) ◽  
pp. 72-73
Keyword(s):  
Blood Coagulation ◽  
Vascular Wall ◽  
Vascular Pathology ◽  
Blood Coagulation Disorders ◽  
Coagulation Disorders ◽  
Close Attention ◽  
Practical Medicine ◽  
Union Conference ◽  
Therapeutic Possibilities

(Poltava. 21-22 / XII 1981) Pathology of the vascular wall and blood coagulation disorders have long attracted close attention of specialists in various fields of theoretical and practical medicine. Therefore, the conference devoted to the study of the influence of vascular pathology on the processes of blood coagulation, the diagnosis of these disorders, as well as the consideration of the therapeutic possibilities of their correction, aroused great interest. The leading experts of our country took part in it.

The history and future of hemostasis research (to the Anniversary of Kirov Research Institute of Hematology and Blood Transfusion FMBA of Russia).

2021 ◽  
Author(s):  
С.В. Игнатьев ◽  
М.Е. Ковтунова ◽  
Е.В. Ройтман ◽  
К.А. Воробьев ◽  
А.В. Лянгузов
Keyword(s):  
Blood Transfusion ◽  
Blood Coagulation ◽  
Russian Federation ◽  
Scientific Research ◽  
Lessons Learned ◽  
Blood Coagulation Disorders ◽  
Coagulation Disorders ◽  
Patient Groups ◽  
The Russian Federation ◽  
Research Institute

В настоящей статье освещаются некоторые этапы становления гемостазиологии как научного направления. Отдельная составляющая работы посвящена истории развития данного раздела медицины, достижениям выдающихся отечественных ученых; освещены ближайшие и отдаленные перспективы научных исследований. Накопленный опыт позволяет авторам надеяться на дальнейшее совершенствование знаний по вопросам свертывания крови и становление специальности «гемостазиология» в Российской Федерации для оказания профессиональной и пациент-ориентированной помощи больным различными заболеваниями, сопровождающимися нарушениями гемокоагуляции. The article highlights some of the stages in hemostasiology development as a scientific direction. A certain part of the work is devoted to the evolution of this branch of medicine, to the achievements of eminent domestic researchers, highlighted the immediate and further prospects of scientific research. The lessons learned allows to hope for advancing knowledge on the blood coagulation issues and the formation of the specialty “hemostasiology” in the Russian Federation to the professional and patient-oriented care of different patient groups accompanied by blood coagulation disorders.

scholarly journals PREDICTIVE FACTORS OF POST EXTRACORPOREAL SHOCK WAVE LITHOTRIPSI COMPLICATION EVENTS

2017 ◽  
Vol 24 (1) ◽  
Author(s):  
Fajar Nugroho Yuniarso ◽  
Untung Tranggono
Keyword(s):  
Shock Wave ◽  
Blood Coagulation ◽  
Kidney Function ◽  
Pain Perception ◽  
Maximum Power ◽  
Blood Coagulation Disorders ◽  
Maximum Frequency ◽  
Coagulation Disorders ◽  
Stone Burden ◽  
Extracorporeal Shock Wave

Objective: To know if pre-morbid factors such as maximum power, maximum frequency, repeated extracorporeal shock wave lithotripsy (ESWL), age, hypertension, diabetic, nutrition, blood coagulation disorders, kidney function disorders, pain perception, stone burden, and stone location, can be use to predict ESWL complication. Material & methods: This study is done retrospectively. Analysis was done on 50 patients undergoing ESWL between July 2014 to December 2015. Free variables which evaluated were maximum power, maximum frequency, repeated ESWL, age, hypertension, diabetic, nutrition, blood coagulation disorders, kidney function disorders, pain perception, stone burden, and stone location. Dependent variable which evaluated was steinstrasse event, post ESWL fever, post-ESWL renal colic, post-ESWL hematuria. Age variable were distributed normally and done bivariate analysis by student T-test. Others were abnormally distributed and analyzed univariately by Mann U Whitney. Results: During study period, 50 patients were collected. Among them, 60% were men and 40% were women. Mean age of patients undergo ESWL were 50.9 +12.7 years. Mean stone size that undergo ESWL were 172.7 + 277.8 mm2. Patients with hypertension before ESWL were 9 patients. Stones were mostly located on kidney pyelum (29 patients), inferior calix (11 patients), superior calix (5 patients), middle calix (4 patients), and 1 patients has staghorn stone. After ESWL, none of the patients complaining severe pain, 35 patient complaining mild pain, and 15 patient complaining moderate pain. Repeated ESWL done in 16 patients (32%). Post-ESWL complication such as hematuria happened on 12 patients, steinstrasse on 1 patient, and colic on 6 patients. None of patients complaining fever. Repeated ESWL happened on 32% patients and have complication risk of hematuria (p=0.043). Hypertension is significantly effecting on hematuria event after ESWL (p=0.015). Conclusion: Hypertension and repeated ESWL can be used as predicting factor of hematuria complication.

Nanomedical Applications of Nanoparticles for Blood Coagulation Disorders

2018 ◽  
pp. 243-277 ◽  
Author(s):  
Agbaje Lateef ◽  
Sunday Ayotunde Ojo ◽  
Joseph Adetunji Elegbede ◽  
Paul Oluwadamilare Akinola ◽  
Emmanuel Olufemi Akanni
Keyword(s):  
Blood Coagulation ◽  
Blood Coagulation Disorders ◽  
Coagulation Disorders
Sign in / Sign up

Export Citation Format

Share Document