scholarly journals Quantum capacitance as a reagentless molecular sensing element

Nanoscale ◽  
2017 ◽  
Vol 9 (40) ◽  
pp. 15362-15370 ◽  
Author(s):  
Paulo R. Bueno ◽  
Flávio C. Bedatty Fernandes ◽  
Jason J. Davis
Keyword(s):  
Molecular Recognition ◽  
Molecular Diagnostics ◽  
Quantum Capacitance ◽  
Sensing Element ◽  
Molecular Sensing ◽  
Electron Occupation

The application of nanoscale capacitance as a transduction of molecular recognition relevant to molecular diagnostics is demonstrated, wherein the energy-related signal relates directly to the electron occupation of quantized states.

scholarly journals Metalloporphyrin Dimers Bridged by a Peptoid Helix: Host-Guest Interaction and Chiral Recognition

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2741 ◽  
Author(s):  
Yen Lee ◽  
Boyeong Kang ◽  
Jiwon Seo
Keyword(s):  
Drug Delivery ◽  
Molecular Recognition ◽  
Complex Formation ◽  
Asymmetric Catalysis ◽  
Spectroscopic Data ◽  
Chiral Recognition ◽  
Guest Complex ◽  
Molecular Sensing ◽  
Host Guest Complex ◽  
Chirality Induction

Co-facial porphyrins have been designed to construct porphyrin tweezers with versatile molecular recognition capabilities. In this study, we synthesized metalloporphyrin–peptoid conjugates (MPPCs) displaying two metalloporphyrins on a peptoid scaffold with either achiral unfolded (1) or helical (2 and 3) secondary structures. Host–guest complexation of MPPCs was realized with various guests of different lengths and basicities, and the extent of complexation was measured by UV-vis and circular dichroism (CD) spectroscopic titration. Intermolecular and intramolecular chirality induction were observed on achiral and chiral peptoid backbones, respectively. Spectroscopic data indicated that a broad scope of achiral guests can be recognized by chiral 2; in particular, longer and more flexible guests were seen to bind more tightly on 2. In addition, chiral 2 provided a distinct CD couplet with dl-, d-, or l-Lys-OMe, which was a result of the diastereomeric host–guest complex formation. Our results indicated that MPPCs can recognize, contrast, and analyze various achiral, chiral, or racemic molecules. Based on co-facial metalloporphyrins present on peptoid scaffolds, we developed a novel class of porphyrin tweezers, which can be further utilized in asymmetric catalysis, molecular sensing, and drug delivery.

scholarly journals In VitroSelection of a Single-Stranded DNA Molecular Recognition Element Specific for Bromacil

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Ryan M. Williams ◽  
Amanda R. Kulick ◽  
Srilakshmi Yedlapalli ◽  
Louisa Battistella ◽  
Cyrus J. Hajiran ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Selection Method ◽  
Detection Methods ◽  
Sensing Element ◽  
Single Stranded Dna ◽  
Recognition Element ◽  
High Affinity ◽  
Recognition Elements ◽  
Molecular Recognition Element

Bromacil is a widely used herbicide that is known to contaminate environmental systems. Due to the hazards it presents and inefficient detection methods, it is necessary to create a rapid and efficient sensing device. Towards this end, we have utilized a stringentin vitroselection method to identify single-stranded DNA molecular recognition elements (MRE) specific for bromacil. We have identified one MRE with high affinity (Kd=9.6 nM) and specificity for bromacil compared to negative targets of selection and other pesticides. The selected ssDNA MRE will be useful as the sensing element in a field-deployable bromacil detection device.

scholarly journals Molecular Sensing: Control of Target Molecular Recognition in a Small Pore Space with Biomolecule-Recognition Gating Membrane (Small 18/2018)

Small ◽  
2018 ◽  
Vol 14 (18) ◽  
pp. 1870082 ◽  
Author(s):  
Hiroto Okuyama ◽  
Yuhei Oshiba ◽  
Hidenori Ohashi ◽  
Takeo Yamaguchi
Keyword(s):  
Molecular Recognition ◽  
Pore Space ◽  
Molecular Sensing ◽  
Small Pore
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