Temporally controlled growth factor delivery from a self-assembling peptide hydrogel and electrospun nanofibre composite scaffold

Nanoscale ◽  
2017 ◽  
Vol 9 (36) ◽  
pp. 13661-13669 ◽  
Author(s):  
Kiara F. Bruggeman ◽  
Yi Wang ◽  
Francesca L. Maclean ◽  
Clare L. Parish ◽  
Richard J. Williams ◽  
...  
Keyword(s):  
Growth Factor ◽  
Regenerative Medicine ◽  
Composite Scaffold ◽  
Controlled Growth ◽  
Growth Factor Delivery ◽  
Tissue Specific ◽  
Biologically Relevant ◽  
Self Assembling ◽  
Peptide Hydrogel

Tissue-specific self-assembling peptide (SAP) hydrogels designed based on biologically relevant peptide sequences have great potential in regenerative medicine.

scholarly journals Bioinspired Self-assembling Peptide Hydrogel with Proteoglycan-assisted Growth Factor Delivery for Therapeutic Angiogenesis

Theranostics ◽  
2019 ◽  
Vol 9 (23) ◽  
pp. 7072-7087 ◽  
Author(s):  
Lu-Chieh Huang ◽  
Huan-Chih Wang ◽  
Liang-Hsin Chen ◽  
Chia-Yu Ho ◽  
Pei-Hsuan Hsieh ◽  
...  
Keyword(s):  
Growth Factor ◽  
Therapeutic Angiogenesis ◽  
Growth Factor Delivery ◽  
Self Assembling ◽  
Peptide Hydrogel

scholarly journals Trypsin Pre‐Treatment Combined With Growth Factor Functionalized Self‐Assembling Peptide Hydrogel Improves Cartilage Repair in Rabbit Model

2019 ◽  
Vol 37 (11) ◽  
pp. 2307-2315 ◽  
Author(s):  
Gustavo Zanotto ◽  
Paul Liebesny ◽  
Myra Barrett ◽  
Hannah Zlotnick ◽  
Alan Grodzinsky ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cartilage Repair ◽  
Rabbit Model ◽  
Self Assembling ◽  
Pre Treatment ◽  
Peptide Hydrogel

Low viscosity-PLGA scaffolds by compressed CO2foaming for growth factor delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (74) ◽  
pp. 70510-70519 ◽  
Author(s):  
L. Diaz-Gomez ◽  
F. Yang ◽  
J. A. Jansen ◽  
A. Concheiro ◽  
C. Alvarez-Lorenzo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Regenerative Medicine ◽  
Growth Factor Delivery ◽  
Low Viscosity ◽  
Polymeric Scaffolds ◽  
Promising Solution ◽  
Compressed Fluids ◽  
Foaming Technology

Foaming technology using supercritical and compressed fluids has emerged as a promising solution in regenerative medicine for manufacturing porous polymeric scaffolds.

scholarly journals Development of nano- and microscale chondroitin sulfate particles for controlled growth factor delivery

2011 ◽  
Vol 7 (3) ◽  
pp. 986-995 ◽  
Author(s):  
Jeremy J. Lim ◽  
Taymour M. Hammoudi ◽  
Andrés M. Bratt-Leal ◽  
Sharon K. Hamilton ◽  
Kirsten L. Kepple ◽  
...  
Keyword(s):  
Growth Factor ◽  
Chondroitin Sulfate ◽  
Controlled Growth ◽  
Growth Factor Delivery

scholarly journals Aptamer based spatiotemporally controlled growth factor patterning for tunable local microvascular network formation in engineered tissues

2020 ◽  
Author(s):  
Deepti Rana ◽  
Ajoy Kandar ◽  
Nasim Salehi-Nik ◽  
Ilyas Inci ◽  
Bart Koopman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Network Formation ◽  
Factor Loading ◽  
Controlled Growth ◽  
Growth Factor Delivery ◽  
Temporal Control ◽  
Microvascular Network ◽  
Complementary Sequence ◽  
Engineered Tissue ◽  
Loading Methods

AbstractSpatiotemporally controlled growth factor availability is of crucial importance for achieving hierarchically organized vascular network formation within engineering tissues. Even though current growth factor delivery systems can provide sustained release and growth factor delivery on demand, they generally do not facilitate temporal control over the release rates and thus adaptation in accordance with the needs of growing engineered tissue. Additionally, with conventional growth factor loading methods, growth factors are often subjected to organic solvents or harsh conditions, leading to lower bioactivity and denaturation of the proteins. To overcome these limitations, this manuscript reports on the development of VEGF specific 5’ acrydite modified aptamer functionalized GelMA hydrogels. The covalently incorporated aptamers can selectively bind to proteins with high affinity and specificity, and can thus sequester the target protein from the surrounding environment. The manuscript shows that this not only provides temporal control over the growth factor release via complementary sequence hybridization, but also enables local control of microvascular network formation in 3D.

Sign in / Sign up

Export Citation Format

Share Document