Mechanism of mechanically induced optoelectronic and spintronic phase transitions in 1D graphene spirals: insight into the role of interlayer coupling

Nanoscale ◽  
2017 ◽  
Vol 9 (27) ◽  
pp. 9693-9700 ◽  
Author(s):  
Xiaodong Xu ◽  
Bingyi Liu ◽  
Wenyu Zhao ◽  
Yongyuan Jiang ◽  
Linhua Liu ◽  
...  
Keyword(s):  
Phase Transitions ◽  
Interlayer Coupling ◽  
Underlying Mechanism ◽  
Insight Into

The underlying mechanism of the optoelectronic and spintronic phase transitions of GSs is rooted in the attenuation of the interlayer coupling.

Role of metabolism in K-induced tension changes in guinea pig taenia coli

1965 ◽  
Vol 208 (6) ◽  
pp. 1203-1205 ◽  
Author(s):  
M. Pfaffman ◽  
N. Urakawa ◽  
W. C. Holland
Keyword(s):  
Guinea Pig ◽  
Active Transport ◽  
Underlying Mechanism ◽  
Taenia Coli ◽  
Na Transport ◽  
Phasic Response ◽  
Metabolic Intermediates ◽  
Substrate Removal ◽  
Insight Into

Further insight into the underlying mechanism(s) of the K-induced phasic and tonic contractions of the taenia coli of the guinea pig was obtained by examining the effects of various metabolic intermediates, inhibitors of metabolism and active transport, on these responses. Evidence is presented to support the thesis that the tonic response is dependent on the aerobic breakdown of carbohydrates and is abolished by substrate removal, a decrease of temperature, DNP, lithium, and ouabain. These same factors have little or no effect on the phasic response. From the evidence presented, it is concluded that the phasic response is a passive process, whereas the tonic contracture is an active one depending on metabolism and possibly linked to active Na transport.

scholarly journals Bifidobacterium infantis Metabolizes 2′Fucosyllactose-Derived and Free Fucose Through a Common Catabolic Pathway Resulting in 1,2-Propanediol Secretion

2020 ◽  
Vol 7 ◽  
Author(s):  
Liv R. Dedon ◽  
Ezgi Özcan ◽  
Asha Rani ◽  
David A. Sela
Keyword(s):  
Gut Microbiome ◽  
Bifidobacterium Longum ◽  
Underlying Mechanism ◽  
Catabolic Pathway ◽  
Oligosaccharide Structure ◽  
Infant Gut Microbiome ◽  
Microbe Interactions ◽  
The Impact ◽  
Insight Into

Human milk oligosaccharides (HMOs) enrich beneficial bifidobacteria in the infant gut microbiome which produce molecules that impact development and physiology. 2′fucosyllactose (2′FL) is a highly abundant fucosylated HMO which is utilized by Bifidobacterium longum subsp. infantis, despite limited scientific understanding of the underlying mechanism. Moreover, there is not a current consensus on whether free fucose could be metabolized when not incorporated in a larger oligosaccharide structure. Based on metabolic and genomic analyses, we hypothesize that B. infantis catabolizes both free fucose and fucosyl oligosaccharide residues to produce 1,2-propanediol (1,2-PD). Accordingly, systems-level approaches including transcriptomics and proteomics support this metabolic path. Co-fermentation of fucose and limiting lactose or glucose was found to promote significantly higher biomass and 1,2-PD concentrations than individual substrates, suggesting a synergistic effect. In addition, and during growth on 2′FL, B. infantis achieves significantly higher biomass corresponding to increased 1,2-PD. These findings support a singular fucose catabolic pathway in B. infantis that is active on both free and HMO-derived fucose and intimately linked with central metabolism. The impact of fucose and 2′FL metabolism on B. infantis physiology provides insight into the role of fucosylated HMOs in influencing host- and microbe-microbe interactions within the infant gut microbiome.

scholarly journals In-store interactive advertising screens: the effect of interactivity on impulse buying explained by self-agency

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Anne Moes ◽  
Marieke Fransen ◽  
Bob Fennis ◽  
Tibert Verhagen ◽  
Harry van Vliet
Keyword(s):  
Field Experiments ◽  
Underlying Mechanism ◽  
Impulse Buying ◽  
Content Type ◽  
Mediating Role ◽  
Interactive Advertising ◽  
Impulse Purchases ◽  
Mediating Factor ◽  
Insight Into

PurposePhysical stores are increasingly dependent on impulse visits and the impulse purchases of passers-by. Interactive advertising screens in store windows could help retailers increase impulse-visit urges and impulse-buying urges. However, the effects of interactive screens in physical surroundings have not been studied before. Therefore, this study aimed to examine the effect of interactive screens on impulse urges and gain insight into the underlying mechanism that explains the possible effect.Design/methodology/approachAn interactive screen was placed in a store window. Using three field experiments, we studied the effect of interactivity-level (high vs low) on the impulse-visit and impulse-buying urges of passers-by, and the mediating role of self-agency in these effects.FindingsHighly interactive (compared to less interactive) advertising screens in store windows positively affect impulse-visit and impulse-buying urges through self-agency. Retailers can therefore use interactive advertising screens to increase the number of impulse purchases if feelings of self-agency are activated.Originality/valueThis is the first study to examine the extent to which interactive screens in a store window enhance the impulse-visit and impulse-buying urges of passers-by and the mediating factor of these effects. By conducting three field experiments, we achieved a high external validity and managed to share very reliable results owing to the replication of the findings.

scholarly journals Solving the Puzzle: What Is the Role of Progestogens in Neovascularization?

Biomolecules ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1686
Author(s):  
Zhi Xia ◽  
Jian Xiao ◽  
Qiong Chen
Keyword(s):  
Progesterone Receptor ◽  
Sex Steroids ◽  
Underlying Mechanism ◽  
Physiological Changes ◽  
Exact Role ◽  
The Past ◽  
Naturally Occurring ◽  
Pathological Conditions ◽  
Insight Into

Ovarian sex steroids can modulate new vessel formation and development, and the clarification of the underlying mechanism will provide insight into neovascularization-related physiological changes and pathological conditions. Unlike estrogen, which mainly promotes neovascularization through activating classic post-receptor signaling pathways, progesterone (P4) regulates a variety of downstream factors with angiogenic or antiangiogenic effects, exerting various influences on neovascularization. Furthermore, diverse progestins, the synthetic progesterone receptor (PR) agonists structurally related to P4, have been used in numerous studies, which could contribute to unequal actions. As a result, there have been many conflicting observations in the past, making it difficult for researchers to define the exact role of progestogens (PR agonists including naturally occurring P4 and synthetic progestins). This review summarizes available evidence for progestogen-mediated neovascularization under physiological and pathological circumstances, and attempts to elaborate their functional characteristics and regulatory patterns from a comprehensive perspective.

Role of Salicylic Acid in Heavy Metal Stress Tolerance: Insight into Underlying Mechanism

2017 ◽  
pp. 123-144 ◽  
Author(s):  
Sukhmeen Kaur Kohli ◽  
Neha Handa ◽  
Ravdeep Kaur ◽  
Vinod Kumar ◽  
Kanika Khanna ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Salicylic Acid ◽  
Stress Tolerance ◽  
Heavy Metal Stress ◽  
Underlying Mechanism ◽  
Metal Stress ◽  
Insight Into

scholarly journals More insight into microscopic properties of RN-AdS black hole surrounded by quintessence via an alternative extended phase space

2018 ◽  
Vol 15 (10) ◽  
pp. 1850171 ◽  
Author(s):  
M. Chabab ◽  
H. El Moumni ◽  
S. Iraoui ◽  
K. Masmar ◽  
S. Zhizeh
Keyword(s):  
Phase Transition ◽  
Black Hole ◽  
Phase Transitions ◽  
Phase Space ◽  
Microscopic Structure ◽  
Extended Phase Space ◽  
Extended Phase ◽  
Horizon Radius ◽  
Insight Into

In this work, we study the phase transition of the charged-AdS black hole surrounded by quintessence via an alternative extended phase space defined by the charge square [Formula: see text] and her conjugate [Formula: see text], a quantity proportional to the inverse of horizon radius, while the cosmological constant is kept fixed. The equation of state is derived under the form [Formula: see text] and the critical behavior of such black hole analyzed. In addition, we examine the role of the quintessence parameter and its effects on phase transitions. Besides that, we explore the connection between the microscopic structure and Ruppeiner geothermodynamics. We also find that, at certain points of the phase space, the Ruppeiner curvature is characterised by the presence of singularities that are interpreted as a signal of the occurrence of the phase transitions.

scholarly journals The Role of Acetate in the Antagonization of Oxalate: A Potential Causative Molecule for Heart Disease and Cancer Death

2020 ◽  
Vol 15 (3) ◽  
pp. 1934578X2091369 ◽  
Author(s):  
Shanshan An ◽  
Xiaoxia Li ◽  
Man Tang ◽  
Meng Xing ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Annexin V ◽  
Fluorescein Isothiocyanate ◽  
Underlying Mechanism ◽  
Sodium Oxalate ◽  
Protective Effects ◽  
Anticancer Effects ◽  
Propidium Iodide Staining ◽  
Strong Acids ◽  
Insight Into

Previous reports demonstrated the anticancer effects and the protective effects on cardiovascular diseases of vinegar products. The molecular mechanism underlying these phenomena is not well elucidated. It was proposed that carcinogenesis is triggered by the formation of local strong acids such as HCl. Cancer cells may overproduce weak or moderate organic acids such as oxalate to antagonize strong acids, and calcium oxalate may cause organ failure and death. This study aimed at elucidating the underlying mechanism on the antagonism of apoptosis by acetate on oxalate. Quantitation of cell apoptosis of HEK293T cells in the presence of sodium oxalate and compounds with similar structures to oxalate was conducted by using Annexin V-fluorescein isothiocyanate/propidium iodide staining via flow cytometry. The data indicate that acetate could attenuate the proapoptotic functions of oxalate. This study yields insight into the anticancer and antidisease functions of vinegar products and opens up a new path in the use of weak acetic acid in the prevention and treatment of cancer.

scholarly journals Quantitative Phosphoproteomics Reveals System-Wide Phosphorylation Network Altered by Spry in Mouse Mammary Stromal Fibroblasts

2019 ◽  
Vol 20 (21) ◽  
pp. 5400 ◽  
Author(s):  
Tiezhu Shi ◽  
Linli Yao ◽  
Ying Han ◽  
Piliang Hao ◽  
Pengfei Lu
Keyword(s):  
Cancer Progression ◽  
Receptor Tyrosine Kinase ◽  
Normal Development ◽  
Underlying Mechanism ◽  
Phosphorylation Sites ◽  
Additional Insight ◽  
Stromal Fibroblasts ◽  
Rtk Signaling ◽  
Insight Into

Understanding the fundamental role of the stroma in normal development and cancer progression has been an emerging focus in recent years. The receptor tyrosine kinase (RTK) signaling pathway has been reported playing critical roles in regulating the normal and cancer microenvironment, but the underlying mechanism is still not very clear. By applying the quantitative phosphoproteomic analysis of Sprouty proteins (SPRYs), generic modulators of RTK signaling and deleted mouse mammary fibroblasts, we quantified a total of 11,215 unique phosphorylation sites. By contrast, 554 phosphorylation sites on 425 proteins had SPRY-responsive perturbations. Of these, 554 phosphosites, 362 sites on 277 proteins, were significantly increased, whereas 192 sites on 167 proteins were decreased. Among the regulated proteins, we identified 31 kinases, 7 phosphatases, and one phosphatase inhibitor that were not systematically characterized before. Furthermore, we reconstructed a phosphorylation network centered on RTK signaling regulated by SPRY. Collectively, this study uncovered a system-wide phosphorylation network regulated by SPRY, providing an additional insight into the complicated RTK signaling pathways involved in the mammary gland microenvironment.

scholarly journals Clinical Value and Underlying Mechanisms of Upregulated LINC00485 in Hepatocellular Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Xinyu Zhu ◽  
Yanlin Feng ◽  
Dingdong He ◽  
Zi Wang ◽  
Fangfang Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Mechanisms ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Underlying Mechanism ◽  
Clinical Value ◽  
Serum Samples ◽  
Underlying Mechanisms ◽  
Insight Into

AimsThis study aimed to reveal the functional role of LINC00485 in hepatocellular carcinoma (HCC).Materials & Methods210 serum samples from Zhongnan Hospital of Wuhan University were employed to evaluate clinical value of LINC00485. Bioinformatics analysis was adopted to explore its potential mechanisms.ResultsLINC00485 was confirmed to be upregulated in HCC tissues and serum samples. Survival analysis and receiver operating characteristic curve revealed its prognostic and diagnostic roles. The combination of serum LINC00485 with AFP can remarkably improve diagnostic ability of HCC. Exploration of the underlying mechanism demonstrated that LINC00485 might exert pro-oncogenic activity by LINC00485—three miRNAs—four mRNAs network.ConclusionsOur study unveiled that upregulated LINC00485 could act as a potential diagnostic and prognostic biomarker and provide a novel insight into the molecular mechanisms of LINC00485 in HCC pathogenesis.

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